DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est7 and cel.2

DIOPT Version :9

Sequence 1:	NP_524261.1	Gene:	alpha-Est7 / 40901	FlyBaseID:	FBgn0015575	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_001120027.1	Gene:	cel.2 / 100144991	XenbaseID:	XB-GENE-1217488	Length:	552	Species:	Xenopus tropicalis

Alignment Length:	570	Identity:	165/570 - (28%)
Similarity:	251/570 - (44%)	Gaps:	86/570 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 VADTEYGQVRGI-KRLSLYDVPYFS-FEGIPYAQPPVGELRFKAPQRPIPWERVRDCSQPKDKAV 96
            |..||.|.|.|. |::.:....|.. |:|||:|.||   ..|:..::...|.........|.:.:
Frog    24 VVHTEGGFVEGTNKKIGVVFPDYIDIFKGIPFAAPP---KPFEKAEKHPGWSGTLQAKDYKPRCL 85

  Fly    97 QVQFVFDKVEGSEDCLYLNVYTNNVKPDKAR--PVMVWIHGGGFIIGE-------ANREWYGPDY 152
            |.....|.|.||.|||||||:....:...:.  ||||||.||||::|.       :|..:.|.:.
Frog    86 QATITQDNVFGSLDCLYLNVWVPQTRSQVSTNLPVMVWIFGGGFLLGSGQGANFLSNYLYDGEEV 150

  Fly   153 FMKEDVVLVTIQYRLGALGFMSLKSPELNVPGNAGLKDQVLALKWIKNNCASFGGDPNCITVFGE 217
            .|:..|::||..||:|.|||:|  :.:.|.|||.||.||.:|:.|:|.|.|:||||||.||:|||
Frog   151 AMRGKVIVVTFNYRVGPLGFLS--TGDSNAPGNYGLWDQHMAIAWVKRNIAAFGGDPNNITLFGE 213

  Fly   218 SAGGASTHYMMLTDQTQGLFHRGILQSGSAICPWAYNGDITHNPYRIAKLVGYK---GEDNDKDV 279
            ||||||.....||....||..|.|.|||..:||||    |..:|...||.:..|   ..:|.|::
Frog   214 SAGGASVSLQTLTPYNVGLIKRAISQSGVGLCPWA----IQRDPLTWAKSLASKLGCPVNNTKEL 274

  Fly   280 LEFLQNVKAKDL-IRVEENVLTLEERMNKIMFAFGPSLEPFSTPECVISKPPKEMMKTAWSNSIP 343
            .:.|:|.....| |..:..:..||..:...: |:.|.::....|:     .|:.:...|  ..:.
Frog   275 ADCLRNTDPGALTIAYQLQLFNLEYPLVHYL-AYSPVIDGDFIPD-----EPRNLFSNA--AGVD 331

  Fly   344 MFIGNTSYEGLLWV---------PEVKLMPQVLQQLDAGTPF---IPKELLA---------TEPS 387
            ...|..:.:|.|:.         |..|:..:.:|::..|...   :|...:|         |.||
Frog   332 YIAGVNNMDGHLFAGVDLPAINQPLHKISTEQVQKVVRGLTLAKGVPALDIAYDLYTAGWGTNPS 396

  Fly   388 KEKLDSWSAQIRDVHRTGSESTPDNYMDLCSIYYFVFPALRVVHSRHAYAAGAPVYFYRYDFDSE 452
            :|          |:.||..|...|        |.|:......:...:..|.||..|.|.:...|.
Frog   397 QE----------DMKRTVVEVETD--------YIFLVATQEALALHYQNAKGAKTYSYMFSHPSR 443

  Fly   453 ELIFPYRIMRLGRGVKGVSHADDLSYQFSSLLARRLPKESREYRNIERTVGIWTQFAATGNPYSE 517
            ..::|        ...|..||:||.:.|....:..|....|:....:..:..||.|||||:|
Frog   444 MPVYP--------SWMGADHAEDLQFMFGKPFSTPLAYRPRDRDVAQYMIAYWTNFAATGDP--- 497

  Fly   518 KINGMDTLTIDPVRKSDEVIKCLNISDDLKFIDLPE---WPKLKVWESLY 564
             ..|..::....:..|.|..:.|.|:..:.:..:.:   .|.::.|...:
Frog   498 -SKGESSIPTPWLAYSTENGQYLEINHKINYQSMKQSLRSPYVRFWAQTF 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est7	NP_524261.1	COesterase	27..514	CDD:278561	157/515 (30%)
alpha-Est7	NP_524261.1	Aes	<116..>221	CDD:223730	51/113 (45%)
cel.2	NP_001120027.1	COesterase	24..542	CDD:365897	164/564 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000