Protein Alignment SMAD5 and Med

DIOPT Version :10

• Sequence 1: NP_005894.3
• Gene: SMAD5 / 4090
• HGNCID: 6771
• Length: 465
• Species: Homo sapiens
• Sequence 2: NP_524610.1
• Gene: Med / 43725
• FlyBaseID: FBgn0288966
• Length: 771
• Species: Drosophila melanogaster
• Alignment Length: 725
• Identity: 207/725 - (28%)
• Similarity: 278/725 - (38%)
• Gaps: 295/725 - (40%)

Human    15 VKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSSPG-QPSKCVTIPRSLDGRLQV 78
            |..|:..:||.|.|.:|::|:::||||||:|:..::.|..|:::.| .|||||||.|:|||||||
  Fly    48 VHSLMCHRQGGESEGFAKRAIESLVKKLKEKRDELDSLITAITTNGAHPSKCVTIQRTLDGRLQV 112

Human    79 SHRKGLPHVIYCRVWRWPDLQSHHELKPLDICEFPFGSKQKEVCINPYHYKRVESPVL------- 136
            :.|||.|||||.|:||||||.. :|||.:..|.|.|..|...||:|||||:||.||.:
  Fly   113 AGRKGFPHVIYARIWRWPDLHK-NELKHVKYCAFAFDLKCDSVCVNPYHYERVVSPGIDLSGLSL 176

Human   137 ---PPVLVP----------------------RHN---------------------EFNPQHSLLV 155
               |..||.                      :|:                     :.||..::..
  Fly   177 QSGPSRLVKDEYSAGPLVGSMDIDGNDIGTIQHHPTQMVGPGGYGYPQGPSEYVGDANPMSAMFP 241

Human   156 QFRNLSHNEP---------------------------HMPQNATFPDSFHQPN------------ 181
            ..|.:...||                           ..||..| |....|..
  Fly   242 TGRTIPKIEPQDGVAGSRGSWMVPPPPRLGQPPQQQQQQPQQQT-PQPTQQQQAQSQAAAHSLPV 305

Human   182 -----NTPFPLSP--------------------------NSPYPPSPA----------------- 198
                 ..|.|::|                          |||..|:.|
  Fly   306 PHGMPGMPGPMNPGPVMAPPPPPQQAQNPQGNGVHHTQANSPTDPASALAMQQQQQQQQQQQQQQ 370

Human   199 ------SSTYPNSPASSG-------------------------------------------PGSP 214
                  |...||...::|                                           |||.
  Fly   371 QQQQQQSGGVPNGSVNAGGGAAAGGQYYGQPPPVSQMQGAGGGGTSVAPSVHAQQNGYVSQPGSA 435

Human   215 FQLPA----------DTP-----PP----------------------------------AYMPPD 230
            ...|.          .||     ||                                  :..|||
  Fly   436 GSAPVGGGGVFGTAQPTPQQPQQPPTGVQANTGSAGAQAGAGGGAAGTWTGPNTLTYTQSMQPPD 500

Human   231 ----------DQMGQDNSQPMDT-SNNMIPQIMPSISSRDVQPVAYEEPKHWCSIVYYELNNRVG 284
                      ..:..|...|..| ......|..|.:.||  ||    .|::||||.|:||:.:||
  Fly   501 PRSLPGGFWNSSLSGDLGSPQQTPPQQQQQQQQPRLLSR--QP----PPEYWCSIAYFELDTQVG 559

Human   285 EAFHASST--SVLVDGFTDPSNNKSRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVG-GEVYAE 346
            |.|...|.  :|::||:.|||.. :|||||.||||:|....|..|.||||||.|...| |:|:..
  Fly   560 ETFKVPSAKPNVIIDGYVDPSGG-NRFCLGALSNVHRTEQSERARLHIGKGVQLDLRGEGDVWLR 623

Human   347 CLSDSSIFVQSRNCNFHHGFHP-TTVCKI-PSSCSLKIFN----NQEF------------AQLLA 393
            ||||:|:||||...:...|..| ..|.|| |::| :|:|:    :|:.            ||..|
  Fly   624 CLSDNSVFVQSYYLDREAGRTPGDAVHKIYPAAC-IKVFDLRQCHQQMHSLATNAQAAAAAQAAA 687

Human   394 ------QSVNHGFEA--------VYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPL 444
                  |.:..|..:        |.:|.::|.:|:|||||||.:|.||.:..||||||:|||..|
  Fly   688 VAGVANQQMGGGGRSMTAAAGIGVDDLRRLCILRLSFVKGWGPDYPRQSIKETPCWIEVHLHRAL 752

Human   445 QWLDKVLTQM 454
            |.||:||..|
  Fly   753 QLLDEVLHAM 762

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMAD5	NP_005894.3	MH1_SMAD_1_5_9	10..133	CDD:199814	64/118 (54%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	163..249		33/281 (12%)
		MH2_SMAD_1_5_9	265..465	CDD:199822	95/225 (42%)
Med	NP_524610.1	MH1_SMAD_4	42..166	CDD:199816	64/118 (54%)
		MH2_SMAD_4	543..760	CDD:199823	93/218 (43%)