Protein Alignment SMAD5 and Dad

DIOPT Version :10

• Sequence 1: NP_005894.3
• Gene: SMAD5 / 4090
• HGNCID: 6771
• Length: 465
• Species: Homo sapiens
• Sequence 2: NP_001369021.1
• Gene: Dad / 42059
• FlyBaseID: FBgn0020493
• Length: 665
• Species: Drosophila melanogaster
• Alignment Length: 466
• Identity: 113/466 - (24%)
• Similarity: 172/466 - (36%)
• Gaps: 151/466 - (32%)

Human    36 DALVKKLKKKKGAMEELEKALSSPGQPS-------------------KCVTIPRSLDGRLQVSHR 81
            :||:|:||:|:  ..||..|:.|...|.                   :|:.||.......:
  Fly   222 EALMKQLKRKQ--RNELLLAVKSRLDPPTKTQRDVVEPTTTTAPTYLQCILIPCKTQTVWE---- 280

Human    82 KGLPHVIYCRVWRWPDLQSHHELKPLDICEFPFGSKQKEVCINPYHYKRVESPVLPPVLVPRHNE 146
               |||...|::.|.:|.:..|||.|..|  |.......:|.||.|:.|:
  Fly   281 ---PHVTASRLFFWRELWNAKELKRLPTC--PAARDCIYMCCNPLHWFRI--------------- 325

Human   147 FNPQHSLLVQFRNLSHNEPHMPQNATFPDSFHQPNNTPFPLSPNSPYPPSPASSTYPNSPASSGP 211
                                          .|||..       .||.||      |..|......
  Fly   326 ------------------------------LHQPET-------ESPTPP------YQRSKMLRLK 347

Human   212 GSPFQLPADTPPPAYMPPDDQMGQDNSQPMDT--------SNNMIPQIMPSISSRDVQPVAYEEP 268
            .:.|:             :|......|..:.|        ||...|.:..|:::        :..
  Fly   348 DADFE-------------EDSQNDAKSAALSTWSAESTSISNIYKPALYESVTT--------DGK 391

Human   269 KH------WCSIVYYELNNRVGEAFHASSTSVLVDGFTD--PSNNKSRFCLGLLSNVNR--NSTI 323
            .|      ||.|.|:|:.:||||.|||.:.:|.:  :||  .::.....||..|:....  :|.:
  Fly   392 DHNINSQVWCQIAYWEMAHRVGEFFHAKTNAVNI--YTDGIVASEVDSMCLRDLTPAGNQIHSVV 454

Human   324 ENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNCNFHHGFHPT------TVCKIPSSCSLKI 382
            ...|..:|.||.|....|:|:.....:::|||.|          ||      .|||:.....||.
  Fly   455 PKARHTVGLGVTLSLENGDVWIYNRGNTTIFVDS----------PTLSENLDRVCKVMPGYCLKA 509

Human   383 FNNQEFAQLLAQSVNHGFEAVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHL-HGPLQW 446
            |.... |:||:.. :||...:..:... :|::||.||||.:|.|||:...|||:|:|. |...|:
  Fly   510 FETNR-AELLSMR-DHGHHPMGPVDYF-SIKISFGKGWGRDYKRQDIMGCPCWLEVHFSHLRXQY 571

Human   447 LDKVLTQMGSP 457
            |  :|.:...|
  Fly   572 L--MLARSAGP 580

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMAD5	NP_005894.3	MH1_SMAD_1_5_9	10..133	CDD:199814	31/115 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	163..249		15/93 (16%)
		MH2_SMAD_1_5_9	265..465	CDD:199822	65/210 (31%)
Dad	NP_001369021.1	MH1_SMAD_6_7	197..329	CDD:199813	32/162 (20%)
		MH2_I-SMAD	400..565	CDD:199821	59/179 (33%)