Protein Alignment SMAD5 and Mad

DIOPT Version :10

• Sequence 1: NP_005894.3
• Gene: SMAD5 / 4090
• HGNCID: 6771
• Length: 465
• Species: Homo sapiens
• Sequence 2: NP_001259992.1
• Gene: Mad / 33529
• FlyBaseID: FBgn0011648
• Length: 525
• Species: Drosophila melanogaster
• Alignment Length: 465
• Identity: 342/465 - (73%)
• Similarity: 384/465 - (82%)
• Gaps: 23/465 - (4%)

Human     1 MTSMASLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSSPGQPSKC 65
            |:::.|||||||||||:|||||||||||||||||||:|||||||:|||:||||:|||.|||||||
  Fly    84 MSTLGSLFSFTSPAVKKLLGWKQGDEEEKWAEKAVDSLVKKLKKRKGAIEELERALSCPGQPSKC 148

Human    66 VTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLDICEFPFGSKQKEVCINPYHYKR 130
            ||||||||||||||||||||||||||||||||||||||||||::|::||.:||||||||||||||
  Fly   149 VTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLELCQYPFSAKQKEVCINPYHYKR 213

Human   131 VESPVLPPVLVPRHNEFNPQHSLLVQFRNLSHNEPHMPQNATFPDSFHQPNNTPFPLSPNSPYPP 195
            ||||||||||||||:||.|.||:| ||.:::  ||.||.|.::.:|....::    ||.::....
  Fly   214 VESPVLPPVLVPRHSEFAPGHSML-QFNHVA--EPSMPHNVSYSNSGFNSHS----LSTSNTSVG 271

Human   196 SPASSTYPNSPASSGPGSPFQLPADTPPPAYMPPDDQMGQDNSQPMDTSNNMIPQIMPSISSRDV 260
            ||:|       .:|.|.||:...|.||||||.|.:|  |..|: |.|....:..|:      .||
  Fly   272 SPSS-------VNSNPNSPYDSLAGTPPPAYSPSED--GNSNN-PNDGGQLLDAQM------GDV 320

Human   261 QPVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFTDPSNNKSRFCLGLLSNVNRNSTIEN 325
            ..|:|.||..|.||.|||||.||||.||.::.||:|||||:||||..|.|||.||||||||||||
  Fly   321 AQVSYSEPAFWASIAYYELNCRVGEVFHCNNNSVIVDGFTNPSNNSDRCCLGQLSNVNRNSTIEN 385

Human   326 TRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNCNFHHGFHPTTVCKIPSSCSLKIFNNQEFAQ 390
            ||||||||||||||.|||||||||||:|||||||||:||||||:||||||..|||||||||||||
  Fly   386 TRRHIGKGVHLYYVTGEVYAECLSDSAIFVQSRNCNYHHGFHPSTVCKIPPGCSLKIFNNQEFAQ 450

Human   391 LLAQSVNHGFEAVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMG 455
            ||:||||:|||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Fly   451 LLSQSVNNGFEAVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMG 515

Human   456 SPLNPISSVS 465
            ||.|.|||||
  Fly   516 SPHNAISSVS 525

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMAD5	NP_005894.3	MH1_SMAD_1_5_9	10..133	CDD:199814	110/122 (90%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	163..249		28/85 (33%)
		MH2_SMAD_1_5_9	265..465	CDD:199822	172/199 (86%)
Mad	NP_001259992.1	MH1_SMAD_1_5_9	93..216	CDD:199814	110/122 (90%)
		MH2_SMAD_1_5_9	325..525	CDD:199822	172/199 (86%)