Protein Alignment SMAD5 and Smox

DIOPT Version :10

• Sequence 1: NP_005894.3
• Gene: SMAD5 / 4090
• HGNCID: 6771
• Length: 465
• Species: Homo sapiens
• Sequence 2: NP_511079.1
• Gene: Smox / 31738
• FlyBaseID: FBgn0025800
• Length: 486
• Species: Drosophila melanogaster
• Alignment Length: 527
• Identity: 269/527 - (51%)
• Similarity: 325/527 - (61%)
• Gaps: 109/527 - (20%)

Human     7 LFSFTSPAVKRLLGWKQGDE----EEKWAEKAVDALVKKLKKKKGAMEELEKALSSPGQPSKCVT 67
            :..||...|||||..|:|:|    |.||:||||..||||: ||...:||||:|:|:....::|||
  Fly     1 MLPFTPQVVKRLLALKKGNEDNSVEGKWSEKAVKNLVKKI-KKNSQLEELERAISTQNCQTRCVT 64

Human    68 IPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLDICEFPFGSKQKEVCINPYHYKRVE 132
            :|||.........|||||||||||:||||||||.:||||||.||:.|..:::|:||||||||::|
  Fly    65 VPRSKPAPAGEHLRKGLPHVIYCRLWRWPDLQSQNELKPLDHCEYAFHLRKEEICINPYHYKKIE 129

Human   133 SPVLPPVLVPRHNEFNPQHSLLVQFRNLSHNEPHMPQNATFPDSF---------HQ-PNNTPF-- 185
            ..:|.|..:|                             |.|||.         || ||||.:
  Fly   130 LSILVPKSLP-----------------------------TPPDSIVDYPLDNHTHQIPNNTDYNA 165

Human   186 --------------------PLSPNSPYPPSPASST------YPNSPASSGPGSPFQ-------- 216
                                |:|.:|....:||::.      ..:|.:||...|.:|
  Fly   166 AIIRSASLSPPQYMELGGAGPVSVSSSASSTPATAAGGGGGPSSSSSSSSSAASAYQQQQQQLSF 230

Human   217 ----------------LP-ADTPPPAYMPPDDQMGQDNSQPMDTSNNM-IPQIMPSISSRDVQPV 263
                            :| ..||||.||..|       ..|:|.::|| :.::.|   ..|..||
  Fly   231 GQNMDSQSSVLSVGSSIPNTGTPPPGYMSED-------GDPIDPNDNMNMSRLTP---PADAAPV 285

Human   264 AYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFTDPSNNKSRFCLGLLSNVNRNSTIENTRR 328
            .|.||..||||.|||||.||||.||||..|:.|||||||||:: |||||||||||||..:|.|||
  Fly   286 MYHEPAFWCSISYYELNTRVGETFHASQPSITVDGFTDPSNSE-RFCLGLLSNVNRNEVVEQTRR 349

Human   329 HIGKGVHLYYVGGEVYAECLSDSSIFVQSRNCNFHHGFHPTTVCKIPSSCSLKIFNNQEFAQLLA 393
            ||||||.|||:||||:|||||||||||||.|||..:|:||.||||||..|:||||||||||.||:
  Fly   350 HIGKGVRLYYIGGEVFAECLSDSSIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLS 414

Human   394 QSVNHGFEAVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPL 458
            |||:.||||||:||:||||||||||||||||.||.|||||||||:||:|||||||:||||||||.
  Fly   415 QSVSQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDRVLTQMGSPR 479

Human   459 NPISSVS 465
            .|.||:|
  Fly   480 LPCSSMS 486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMAD5	NP_005894.3	MH1_SMAD_1_5_9	10..133	CDD:199814	72/126 (57%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	163..249		32/149 (21%)
		MH2_SMAD_1_5_9	265..465	CDD:199822	156/199 (78%)
Smox	NP_511079.1	MH1_R-SMAD	7..130	CDD:199812	70/123 (57%)
		MH2_SMAD_2_3	285..475	CDD:199826	149/190 (78%)