Protein Alignment ARRB2 and Arr2

DIOPT Version :10

• Sequence 1: XP_011522160.1
• Gene: ARRB2 / 409
• HGNCID: 712
• Length: 440
• Species: Homo sapiens
• Sequence 2: NP_523976.1
• Gene: Arr2 / 38993
• FlyBaseID: FBgn0000121
• Length: 401
• Species: Drosophila melanogaster
• Alignment Length: 402
• Identity: 175/402 - (43%)
• Similarity: 261/402 - (64%)
• Gaps: 12/402 - (2%)

Human    39 RVFKKSSPNCKLTVYLGKRDFVDHLDKVDPVDGVVLVDPDYLKDRKVFVTLTCAFRYGREDLDVL 103
            :||||::||.|:|.|||:|||:||:|..||||||::|:|||||:||||..|...:|||||:.:|:
  Fly     6 KVFKKATPNGKVTFYLGRRDFIDHIDYCDPVDGVIVVEPDYLKNRKVFGQLATTYRYGREEDEVM 70

Human   104 GLSFRKDLFIATYQAFPPVPNPPRPPTRLQDRLLRKLGQHAHPFFFTIPQNLPCSVTLQPGPEDT 168
            |:.|.|:|.:...| ..|:.||....|.:|::|:||||.:|:||.|..|.|.|.|||||...:|.
  Fly    71 GVKFSKELILCREQ-IVPMTNPNMEMTPMQEKLVRKLGSNAYPFTFHFPPNSPSSVTLQQEGDDN 134

Human   169 GKACGVDFEIRAFCAKSLEEKSHKRNSVRLVIRKVQFAPEKPGPQ-PSAETTRHFLMSDRSLHLE 232
            ||..||::.||||...|.:::.|||:.|.|||:|:|:||...|.: ||:..::.|..|:..:.||
  Fly   135 GKPLGVEYTIRAFVGDSEDDRQHKRSMVSLVIKKLQYAPLNRGQRLPSSLVSKGFTFSNGKISLE 199

Human   233 ASLDKELYYHGEPLNVNVHVTNNSTKTVKKIKVSVRQYADICLFSTAQYKCPVAQLEQDD--QVS 295
            .:||:|:|||||.....|.|:|||.|:||.||..:.|:.:|.:.: ||:...|||||..:  .::
  Fly   200 VTLDREIYYHGEKTAATVQVSNNSKKSVKSIKCFIVQHTEITMVN-AQFSKHVAQLETKEGCPIT 263

Human   296 PSSTFCKVYTITPLLSDNREKRGLALDGKLKHEDTNLASSTIVKEG-ANKEVLGILVSYRVKVKL 359
            |.:...|.:.:.||.::|:::.|:||||.||.||.||||||:|:|| :..:..||::||.|::||
  Fly   264 PGANLTKTFYLIPLAANNKDRHGIALDGHLKDEDVNLASSTMVQEGKSTGDACGIVISYSVRIKL 328

Human   360 -VVSRGGDVSVELPFVLMHPKPHDHIPLPRPQSAAPETDVPVDTNLIEFDTNYATDDD-IVFEDF 422
             ..:.||::..::||.|:.|.| ..|...|..:......:....|:..:   |..||| ||||||
  Fly   329 NCGTLGGEMQTDVPFKLLQPAP-GTIEKKRSNAMKKMKSIEQHRNVKGY---YQDDDDNIVFEDF 389

Human   423 ARLRLKGMKDDD 434
            |::|:..:...|
  Fly   390 AKMRMNNVNMAD 401

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ARRB2	XP_011522160.1	Arrestin_N	50..206	CDD:451447	79/155 (51%)
		Arrestin_C	225..380	CDD:214976	66/158 (42%)
Arr2	NP_523976.1	Arrestin_N	17..172	CDD:425619	79/155 (51%)
		Arrestin_C	192..350	CDD:214976	66/158 (42%)