DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ARRB2 and Arr1

DIOPT Version :9

Sequence 1:	XP_011522160.1	Gene:	ARRB2 / 409	HGNCID:	712	Length:	440	Species:	Homo sapiens
Sequence 2:	NP_001246073.1	Gene:	Arr1 / 35078	FlyBaseID:	FBgn0000120	Length:	364	Species:	Drosophila melanogaster

Alignment Length:	346	Identity:	152/346 - (43%)
Similarity:	234/346 - (67%)	Gaps:	5/346 - (1%)

- Green bases have known domain annotations that are detailed below.

Human    39 RVFKKSSPNCKLTVYLGKRDFVDHLDKVDPVDGVVLVDPDYLK-DRKVFVTLTCAFRYGREDLDV 102
            :||||.|||..:|:|:.:|||||.:.:|:|:||::::|.:|:: :||:||.|.|.|||||||.::
  Fly     6 KVFKKCSPNNMITLYMNRRDFVDSVTQVEPIDGIIVLDDEYVRQNRKIFVQLVCNFRYGREDDEM 70

Human   103 LGLSFRKDLFIATYQAFPPVPNPPRPPTRLQDRLLRKLGQHAHPFFFTIPQNLPCSVTLQPGPED 167
            :||.|:|:|.:.:.|..||.....: .|::|:|||:|||.:|:||...:|.:.|.||.||....|
  Fly    71 IGLRFQKELTLVSQQVCPPQKQDIQ-LTKMQERLLKKLGSNAYPFVMQMPPSSPASVVLQQKASD 134

Human   168 TGKACGVDFEIRAFCAKSLEEKSHKRNSVRLVIRKVQFAPEKPGPQPSAETTRHFLMSDRSLHLE 232
            ..:.|||.:.::.|...|..::||:|:::.|.|||||:||.|.|.||.....:.||:|...|.||
  Fly   135 ESQPCGVQYFVKIFTGDSDCDRSHRRSTINLGIRKVQYAPTKQGIQPCTVVRKDFLLSPGELELE 199

Human   233 ASLDKELYYHGEPLNVNVHVTNNSTKTVKKIKVSVRQYADICLFSTAQYKCPVAQLEQDD--QVS 295
            .:|||:||:|||.::||:.|.|||.|.|||||..|:|..|:.||...|::..:|.:|..:  .::
  Fly   200 VTLDKQLYHHGEKISVNICVRNNSNKVVKKIKAMVQQGVDVVLFQNGQFRNTIAFMETSEGCPLN 264

Human   296 PSSTFCKVYTITPLLSDNREKRGLALDGKLKHEDTNLASSTIVKEGANKEVLGILVSYRVKVKLV 360
            |.|:..||..:.|.|..|.::.|:|::|.:|.:||.|||:|::.....::..||:|||.|||||.
  Fly   265 PGSSLQKVMYLVPTLVANCDRAGIAVEGDIKRKDTALASTTLIASQDARDAFGIIVSYAVKVKLF 329

Human   361 V-SRGGDVSVELPFVLMHPKP 380
            : :.||::..||||:||||||
  Fly   330 LGALGGELCAELPFILMHPKP 350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ARRB2	XP_011522160.1	Arrestin_N	50..206	CDD:278754	66/156 (42%)
ARRB2	XP_011522160.1	Arrestin_C	225..380	CDD:214976	69/157 (44%)
Arr1	NP_001246073.1	Arrestin_N	17..173	CDD:304627	66/156 (42%)
Arr1	NP_001246073.1	Arrestin_C	192..350	CDD:214976	69/157 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3865
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.802101	Normalized mean entropy	S2648
OMA	1	1.010	-	-		QHG52566
OrthoDB	1	1.010	-	-		D340461at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11792
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.880