DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est8 and Ache

DIOPT Version :9

Sequence 1:	NP_524259.2	Gene:	alpha-Est8 / 40899	FlyBaseID:	FBgn0015576	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	XP_038945765.1	Gene:	Ache / 83817	RGDID:	69313	Length:	616	Species:	Rattus norvegicus

Alignment Length:	599	Identity:	166/599 - (27%)
Similarity:	258/599 - (43%)	Gaps:	128/599 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 RSNDKVIADTVYGKVKGVKWQSIYGNNYYSFEGIPFAKPPVGELRFKAPVEPEHWSDVKRCTHVR 92
            |.:.:::.....|:::|::.:: .|....:|.|||||:||||..||..|.....||.:...|..:
  Rat    34 REDPQLLVRVRGGQLRGIRLKA-PGGPVSAFLGIPFAEPPVGSRRFMPPEPKRPWSGILDATTFQ 97

  Fly    93 AKPCQ-VNIVLKQVQG----------SEDCLYLNVYTRELHPHRPLPVLVWIYGGGFQMGEASRD 146
            ....| |:.:....:|          |||||||||:|....|..|.|||:|||||||..|.:|.|
  Rat    98 NVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPTSPTPVLIWIYGGGFYSGASSLD 162

  Fly   147 LYSPDYI-MMEHVVLVVISYRLGALGFLSLADEELDVPGNAGLKDQVMALRWVKRNCQFFGGDPD 210
            :|...:: .:|..|||.::||:|..|||:|.... |.|||.||.||.:||:||:.|...|||||.
  Rat   163 VYDGRFLAQVEGTVLVSMNYRVGTFGFLALPGSR-DAPGNVGLLDQRLALQWVQENIAAFGGDPM 226

  Fly   211 NITVFGESAGGASTHYMMLTDQAKGLFHKTIIMSGSALAPWAQTPTHINWPYRLAQATGYTGDAN 275
            ::|:||||||.||....:|:..::.|||:.::.||:...||               ||...|:|.
  Rat   227 SVTLFGESAGAASVGMHILSLPSRSLFHRAVLQSGTPNGPW---------------ATVSAGEAR 276

  Fly   276 DR-DIFAHLKKC----------KASSMLKV--AEDIITMEER---HQRLTMFSFGPTIE-PYL-- 321
            .| .:.|.|..|          :..|.|:.  |:|::..|..   .:.:..|||.|.:: .:|
  Rat   277 RRATLLARLVGCPPGGAGGNDTELISCLRTRPAQDLVDHEWHVLPQESIFRFSFVPVVDGDFLSD 341

  Fly   322 TPHCVIPKSPLEMMRDCWGNSIPMVIGGNSFEG--LLMF--PEVNKWPELLCQLGDCENLAPQDA 382
            ||..:|.....:        .:.:::|....||  .|::  |..:|         |.|:|.
  Rat   342 TPEALINTGDFQ--------DLQVLVGVVKDEGSYFLVYGVPGFSK---------DNESLI---- 385

  Fly   383 HVDEQQRKAF--GKKVRELYFGDRTPGRKTILEYSDLFSYKYFWHGIH-------RTLLSR--AH 436
                 .|..|  |.::......| ......:|.|:|       |  :|       |..:|.  ..
  Rat   386 -----SRAQFLAGVRIGVPQASD-LAAEAVVLHYTD-------W--LHPEDPAHLRDAMSAVVGD 435

  Fly   437 HAPLAPTF------------LYRFDFDSKHFNIMRIITCGRKVRGTCHADDLSYLFYNAAAKKLK 489
            |..:.|..            :|.:.|:.:...:...:.     .|..|..::.::|.......|.
  Rat   436 HNVVCPVAQLAGRLAAQGARVYAYIFEHRASTLTWPLW-----MGVPHGYEIEFIFGLPLDPSLN 495

  Fly   490 RRTAEFKTIKRLVSMVVHFAISGDPNIPMVCQDEKEQPRGAWLPISKDDKVFQCLNISHDVHVID 554
            ....|....:||:....:||.:||||.|   :|.| .||  |.|.:...:.:..||:.      .
  Rat   496 YTVEERIFAQRLMKYWTNFARTGDPNDP---RDSK-SPR--WPPYTTAAQQYVSLNLK------P 548

  Fly   555 LPEAEKLRLWDCIY 568
            |.....||...|.:
  Rat   549 LEVRRGLRAQTCAF 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est8	NP_524259.2	COesterase	29..564	CDD:278561	164/592 (28%)
alpha-Est8	NP_524259.2	Aes	<116..>221	CDD:223730	53/105 (50%)
Ache	XP_038945765.1	COesterase	37..563	CDD:395084	165/596 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910