DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est8 and Ces2g

DIOPT Version :9

Sequence 1:	NP_524259.2	Gene:	alpha-Est8 / 40899	FlyBaseID:	FBgn0015576	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_932116.2	Gene:	Ces2g / 72361	MGIID:	1919611	Length:	560	Species:	Mus musculus

Alignment Length:	600	Identity:	178/600 - (29%)
Similarity:	258/600 - (43%)	Gaps:	148/600 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 IADTVYGKVKG----VKWQSIYGNNYYSFEGIPFAKPPVGELRFKAPVEPEHWSDVKRCTHVRAK 94
            |..|..|:|:|    ||....   ..::|.||||||||||.|||..|..||.||.|:..|   ::
Mouse    35 IRSTHSGQVQGRLIHVKDTKA---GVHTFLGIPFAKPPVGPLRFAPPEAPEPWSGVRDGT---SQ 93

  Fly    95 P--CQVNI------------VLKQVQGSEDCLYLNVYTRELHPHR--PLPVLVWIYGGGFQMGEA 143
            |  |..|:            .|..|..||||||||:|| ..|...  .|||:|||:||...:|.|
Mouse    94 PAICPQNVTMNMEGLKELKLTLPPVSMSEDCLYLNIYT-PAHAQEGSNLPVMVWIHGGALTVGMA 157

  Fly   144 SRDLYSPDYI-MMEHVVLVVISYRLGALGFLSLADEELDVPGNAGLKDQVMALRWVKRNCQFFGG 207
            |  :|....: ..|.||:|.|.||||.|||.|..||.  ..||.|..|||.|||||::|...|||
Mouse   158 S--MYDGSVLAATEDVVVVAIQYRLGVLGFFSTGDEH--ARGNWGFLDQVAALRWVQQNIAHFGG 218

  Fly   208 DPDNITVFGESAGGASTHYMMLTDQAKGLFHKTIIMSGSALAPWA---------QTPTHINWPYR 263
            :||.:|:|||||||.|....:::..:|||||:.|:.||.||.|..         ||
Mouse   219 NPDRVTIFGESAGGISVSSHVVSPMSKGLFHRAIMESGVALLPGTIFSFSEVVYQT--------- 274

  Fly   264 LAQATGYTGDANDRDIFAHLKKCKASSMLKVAEDIITMEERHQRLTMFSFGPTIEPYLTPHCVIP 328
            :|:.:|.  :|.|.:.   |.:|...   |..|:|:.:.:..|.:          |.:.....:|
Mouse   275 VAKLSGC--EAMDSEA---LVRCLRG---KSEEEILAISKNFQMI----------PGVVDGEFLP 321

  Fly   329 KSPLEMMRDCWGNSIPMVIGGNSFEGLLMFPEVNKWPELLCQLGDC--------ENL-------A 378
            |.|.|::.....:.:|.:||.|:.|...:.|:|         :|..        |||       |
Mouse   322 KHPQELLASADFHPVPSIIGFNNDEYGWIVPKV---------IGSTQTIKGITRENLQAVLKDTA 377

  Fly   379 PQ--------DAHVDEQQRKAFGKKVRELYFGDRTPGRKTILEYSDLFSYKYFWHGIHRTLLSRA 435
            ||        |..::|........|..::.|.:       ::|     .:.:....:......|:
Mouse   378 PQMMLPPECSDLLMEEYMEDIEDPKTLQIQFTE-------MME-----DFMFVIPSLQVAYFQRS 430

  Fly   436 HHAPLAPTFLYRFDFDSKHFNIMRIITCGRKVR----GTCHADDLSYLFYNAAAKKLKRRTAEFK 496
            |    ||.:.|.|...|...         :.||    ...|.|::.::|.:.........|.|.|
Mouse   431 H----APVYFYEFQHQSSFL---------KDVRPPHVNADHGDEVPFVFGSFFWGMKLNLTEEEK 482

  Fly   497 TI-KRLVSMVVHFAISGDPN---IPMVCQDEKEQPRGAWLPISKDDKVFQCLNISHDVHVIDLPE 557
            .: :|::....:||..|:||   :|.            | |:...|:.:..|||...|.  ...:
Mouse   483 LLNRRMMKYWANFARHGNPNSESLPY------------W-PVFDHDEQYLQLNIQPAVG--QFQK 532

  Fly   558 AEKLRLWDCIYDREL 572
            |.||:.|.....|::
Mouse   533 ARKLQFWTKTLPRKI 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est8	NP_524259.2	COesterase	29..564	CDD:278561	176/590 (30%)
alpha-Est8	NP_524259.2	Aes	<116..>221	CDD:223730	53/107 (50%)
Ces2g	NP_932116.2	COesterase	31..539	CDD:278561	176/590 (30%)
Ces2g	NP_932116.2	Aes	72..>337	CDD:223730	107/299 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832731
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.740