DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est8 and Ces2j

DIOPT Version :9

Sequence 1:	NP_524259.2	Gene:	alpha-Est8 / 40899	FlyBaseID:	FBgn0015576	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	XP_038953911.1	Gene:	Ces2j / 685645	RGDID:	1591368	Length:	576	Species:	Rattus norvegicus

Alignment Length:	598	Identity:	168/598 - (28%)
Similarity:	260/598 - (43%)	Gaps:	128/598 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 NYVKFKTNQQRLRSNDKVIADTVYGKVKG----VKWQSIYGNNYYSFEGIPFAKPPVGELRFKAP 76
            |...|.|.|.  :.:...|.:|..|:|:|    ||...   :..::|.||||||||||.|||..|
  Rat    37 NLHSFLTEQG--QDSASPIRNTHTGQVRGSFVHVKDTK---SGIHTFLGIPFAKPPVGPLRFAPP 96

  Fly    77 VEPEHWSDVKRCTHVRAKPCQVNIV---------LKQVQGSEDCLYLNVYTRELHPHRP--LPVL 130
            .:||.||.|:..|...|...|..::         |.::..||||||||:|. ..|.|..  |||:
  Rat    97 EDPEPWSGVRDATSQPAMCLQTAMMNLEGMKETELTKLPMSEDCLYLNIYV-PAHAHEDSNLPVM 160

  Fly   131 VWIYGGGFQMGEASRDLYSPDYIMMEHVVLVVISYRLGALGFLSLADEELDVPGNAGLKDQVMAL 195
            |||:|||...|.||.:..| .....|.:|:|.|.||||.|||.|..|:.  ..||.|..||:.||
  Rat   161 VWIHGGGLVGGSASMNDAS-TLAATEEIVIVSIQYRLGVLGFFSTGDQH--ARGNWGYLDQMAAL 222

  Fly   196 RWVKRNCQFFGGDPDNITVFGESAGGASTHYMMLTDQAKGLFHKTIIMSGSALAPWAQTPTHINW 260
            |||::|..:|||:.|::|:||.||||.|....:::..:|||||:.|:.||.||.|
  Rat   223 RWVQQNIAYFGGNRDSVTIFGVSAGGTSVSSHVVSPMSKGLFHRAIMQSGVALLP---------- 277

  Fly   261 PYRLAQATGYTGDAND--RDIFAHLKKCKASS--------MLKVAEDIITMEERHQRLTMFSFGP 315
                    |...|.::  ....|:|..|:||.        ..|..::|:.:.:..:.:
  Rat   278 --------GLISDTSEVVYKTVANLSGCEASDSEALIRCLRAKSKQEILAINQVFKMI------- 327

  Fly   316 TIEPYLTPHCVIPKSPLEMMRDCWGNSIPMVIGGNSFEG-------LLMFPEVNK-----WPELL 368
               |.:.....:||.|.|::.....:.:|.:||.|:.|.       |.::..:|.     .|..|
  Rat   328 ---PGVVDGKFLPKHPQELLASKDFHPVPSIIGVNTDECGWGVPTILGLYHIINNITRETLPAAL 389

  Fly   369 CQLGDCENLAPQDAHVDEQQRKAFGKKVRELYFGDRTPGRKTILEYSDLFSYKYFWHGIHRTLLS 433
             ::...:.:.|.:. :|         .:.|.|.||.........::.::.....|    ....|.
  Rat   390 -KIAAAQMMLPPEC-ID---------LIMEEYMGDTEDAETLQAQFKEMLGDFIF----VIPALQ 439

  Fly   434 RAH-HAPLAPTFLYRFDFDSKHFNIMRIITCGRKVR----GTCHADDLSYLFYNAAAKKLKRRTA 493
            .|| ....||.:.|.|         ..:::..::||    ...|.||..::|.:.........|.
  Rat   440 VAHFQRSQAPVYFYEF---------QHLLSFIKQVRPFYPKADHGDDTVFVFGSYFWGMTFDLTE 495

  Fly   494 EFKTIKRLVSMV-VHFAISGDPN------IPMVCQDEKEQPRGAWLPISKDDKVFQCLNISHDVH 551
            |.:.:||.|... .:||.:|:||      .|::..||:      :|.::....|.:.|
  Rat   496 EEELLKRRVMKYWANFARTGNPNGEDLPHWPVLDHDEQ------YLQLNSQPAVGRAL------- 547

  Fly   552 VIDLPEAEKLRLW 564
                 :|.:|:.|
  Rat   548 -----KARRLQFW 555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est8	NP_524259.2	COesterase	29..564	CDD:278561	163/583 (28%)
alpha-Est8	NP_524259.2	Aes	<116..>221	CDD:223730	49/106 (46%)
Ces2j	XP_038953911.1	COesterase	50..555	CDD:395084	163/581 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336335
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222591at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.750