DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est8 and Ces1a

DIOPT Version :9

Sequence 1:	NP_524259.2	Gene:	alpha-Est8 / 40899	FlyBaseID:	FBgn0015576	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_001177304.1	Gene:	Ces1a / 679817	RGDID:	1583671	Length:	563	Species:	Rattus norvegicus

Alignment Length:	538	Identity:	170/538 - (31%)
Similarity:	245/538 - (45%)	Gaps:	86/538 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 IADTVYGKVKGVKWQSIYG--NNYYSFEGIPFAKPPVGELRFKAPVEPEHWSDVKRCTHVRAKPC 96
            :.||:.|||.| |:.|:.|  .....|.|:||||||:|.|||..|...|.||.||..|.......
  Rat    25 VVDTLQGKVLG-KYISLEGFTQPVAVFLGVPFAKPPLGSLRFAPPQPAESWSFVKNATSYPPMCS 88

  Fly    97 Q---VNIVLKQV----------QGSEDCLYLNVYT-RELHPHRPLPVLVWIYGGGFQMGEASRDL 147
            |   |..||.:|          :.||||||||:|: .:|.....|||:||::|||...|.||
  Rat    89 QITGVGPVLSEVFTNQLENVPLEYSEDCLYLNIYSPTDLTSKDRLPVMVWVHGGGLLSGGAS--- 150

  Fly   148 YSPDYIMM---EHVVLVVISYRLGALGFLSLADEELDVPGNAGLKDQVMALRWVKRNCQFFGGDP 209
             :.|.:.:   |.||:|||.||||..||||..||.  ..||.|..|||.||:||:.|...|||||
  Rat   151 -TFDGLALSTHEKVVVVVIQYRLGIWGFLSTGDEH--SRGNWGHFDQVAALQWVQNNIVNFGGDP 212

  Fly   210 DNITVFGESAGGASTHYMMLTDQAKGLFHKTIIMSGSALAPWAQTPTHINWPYRLAQ-----ATG 269
            :::|:|||||||.|...::|:...|.|||:.|..||.||     ||.......|||.     |||
  Rat   213 NSVTLFGESAGGESVSVLVLSPLTKNLFHRAISESGVAL-----TPCLFRENTRLAAEQVAIATG 272

  Fly   270 YTGDANDRDIFAHLKKCKASSMLKVAEDII--TMEERHQRLTMFSFGPTIEPYLT---PHCVIPK 329
            .....:     |.:.:|...   |..|:::  |::.:...|.:........|:||   ...::||
  Rat   273 CAATTS-----ADIVRCLRE---KTEEELLATTLKMKFFALDLHGDPRESYPFLTTVIDGVLLPK 329

  Fly   330 SPLEMMRDCWGNSIPMVIGGNSFEGLLMFPEVNKWP------------ELLCQLGDCENLAPQDA 382
            :|.|::.:...|::|.::|.|..|.....|.:..:|            .||.:.....|::
  Rat   330 APEEILSEKNFNTVPYIVGINKQEFGWFIPTMMGYPLSESKLDQKTATSLLWKSYPLTNIS---- 390

  Fly   383 HVDEQQRKAFGKKVRELYF-GDRTPGRKTILEYSDLFSYKYFWHGIHRTLLSRAHHAPLAPTFLY 446
                   |.......|.|. |...|.:|..| :.|:.....|  .:...:::|.|....|.|::|
  Rat   391 -------KELTPVATEKYLGGSDCPDKKKDL-FLDMMGDVLF--AVPSVIVARYHRDARATTYVY 445

  Fly   447 RFDFDSKHFNIMRIITCGRKVRGTCHADDLSYLFYNAAAKKLKRRTAEFKTIKRLVSMVVHFAIS 511
            .|.:.....:.||     .|.....|.|:: |..:.....|......|......::....:||.:
  Rat   446 EFKYHPSFVSDMR-----PKTVIADHGDEV-YSVWGTPFLKEGASEEEINLSTMMMKFWGNFARN 504

  Fly   512 GDPN---IPMVCQ-DEKE 525
            |:||   :|...: ||||
  Rat   505 GNPNGEGLPHWPEYDEKE 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est8	NP_524259.2	COesterase	29..564	CDD:278561	170/538 (32%)
alpha-Est8	NP_524259.2	Aes	<116..>221	CDD:223730	52/108 (48%)
Ces1a	NP_001177304.1	COesterase	24..545	CDD:278561	170/538 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336510
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.740