DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est8 and Bche

DIOPT Version :9

Sequence 1:	NP_524259.2	Gene:	alpha-Est8 / 40899	FlyBaseID:	FBgn0015576	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_075231.1	Gene:	Bche / 65036	RGDID:	619996	Length:	597	Species:	Rattus norvegicus

Alignment Length:	560	Identity:	160/560 - (28%)
Similarity:	245/560 - (43%)	Gaps:	151/560 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 SNDKVIADTVYGKVKGVKWQSIYGNNYYSFEGIPFAKPPVGELRFKAPVEPEHWSDVKRCTHVRA 93
            :.:.||..|..|:|:|:. ..|.|....:|.|||:|:||:|.||||.|.....|.||...|.. |
  Rat    23 TEEDVIITTKTGRVRGLS-MPILGGTVTAFLGIPYAQPPLGSLRFKKPQPLNKWPDVYNATKY-A 85

  Fly    94 KPCQVNI--VLKQVQG----------SEDCLYLNVYTRELHPHRPLP------VLVWIYGGGFQM 140
            ..|..||  .....||          |||||||||:.       |:|      |:||:||||||.
  Rat    86 NSCYQNIDQAFPGFQGSEMWNPNTNLSEDCLYLNVWI-------PVPKPKNATVMVWVYGGGFQT 143

  Fly   141 GEASRDLYSPDYI-MMEHVVLVVISYRLGALGFLSLADEELDVPGNAGLKDQVMALRWVKRNCQF 204
            |.:|..:|...:: .:|.|::|.::||:||||||:..... :.|||.||.||.:||:|::||...
  Rat   144 GTSSLPVYDGKFLTRVERVIVVSMNYRVGALGFLAFPGNS-EAPGNMGLFDQQLALQWIQRNIAA 207

  Fly   205 FGGDPDNITVFGESAGGASTHYMMLTDQAKGLFHKTIIMSGSALAPWA-QTPTHI-NWPYRLAQA 267
            |||:|.::|:||||||.||....:|..|:..||.:.|:.|||:.|||| :.|... |....||:.
  Rat   208 FGGNPKSVTLFGESAGAASVSLHLLCPQSYPLFTRAILESGSSNAPWAVKHPEEARNRTLTLAKF 272

  Fly   268 TGYTGDANDRDIFAHLKKCKASSMLKVAEDIITMEE---RHQRLTMFSFGPTIE-PYLT--PHCV 326
            .|.:.: |:::|...|:.       |..::|:..|:   ....:...:||||:: .:||  ||.:
  Rat   273 IGCSKE-NEKEIITCLRS-------KDPQEILLNEKLVLPSDSIRSINFGPTVDGDFLTDMPHTL 329

  Fly   327 IPKSPLEMMRDCWG-----NSIPMVIGGNSF--------------EGLLM-FPEVNKWPELLCQL 371
            :....::..:...|     .:..:|.|...|              |||.| ||.|:
  Rat   330 LQLGKVKTAQILVGVNKDEGTAFLVYGAPGFSKDNDSLITRREFQEGLNMYFPGVS--------- 385

  Fly   372 GDCENLAPQDAHVDEQQRKAFGKKVRELYF----GDRTP-----------GRKTI----LEYSDL 417
                               :.||:....|:    ||:||           |...|    ||::..
  Rat   386 -------------------SLGKEAILFYYVDWLGDQTPEVYREAFDDIIGDYNIICPALEFTKK 431

  Fly   418 FS-------YKYFWHGIHRTLLSRAHHAPLAPTFLYRFDFDSKHFNIMRIITCGRKVRGTCHADD 475
            |:       :.||.|        |:...|. |.::                       |..|..:
  Rat   432 FAELEINAFFYYFEH--------RSSKLPW-PEWM-----------------------GVMHGYE 464

  Fly   476 LSYLFYNAAAKKLKRRTAEFKTIKRLVSMVVHFAISGDPN 515
            :.::|.....:::....||....:.::....:||..|.||
  Rat   465 IEFVFGLPLERRVNYTRAEEIFSRSIMKTWANFAKYGHPN 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est8	NP_524259.2	COesterase	29..564	CDD:278561	160/560 (29%)
alpha-Est8	NP_524259.2	Aes	<116..>221	CDD:223730	48/111 (43%)
Bche	NP_075231.1	COesterase	21..545	CDD:278561	160/560 (29%)
		Aes	<120..>272	CDD:223730	67/159 (42%)
		AChE_tetra	560..594	CDD:285837
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910