Protein Alignment alpha-Est8 and NLGN4X

DIOPT Version :10

• Sequence 1: NP_524259.2
• Gene: alpha-Est8 / 40899
• FlyBaseID: FBgn0015576
• Length: 574
• Species: Drosophila melanogaster
• Sequence 2: XP_005274621.1
• Gene: NLGN4X / 57502
• HGNCID: 14287
• Length: 836
• Species: Homo sapiens
• Alignment Length: 622
• Identity: 160/622 - (25%)
• Similarity: 266/622 - (42%)
• Gaps: 149/622 - (23%)

  Fly    34 IADTVYGKVKGVKW---QSIYGNNYYSFEGIPFAKPPVGELRFKAPVEPEHWSDVKRCTHVRAK- 94
            :.:|.|||::|::.   ..|.| ....:.|:|:|.||.||.||:.|..|..|:.::..|...|.
Human    47 VVNTNYGKIRGLRTPLPNEILG-PVEQYLGVPYASPPTGERRFQPPEPPSSWTGIRNTTQFAAVC 110

  Fly    95 ------------------PCQVNIVLKQVQG-SEDCLYLNVYT---------------------- 118
                              ...::.::..||. :|||||||:|.
Human   111 PQHLDERSLLHDMLPIWFTANLDTLMTYVQDQNEDCLYLNIYVPTEDGANTKKNADDITSNDRGE 175

  Fly   119 -RELH-PHRPLPVLVWIYGGGFQMGEASRDLYSPDYIMME--------HVVLVVISYRLGALGFL 173
             .::| .:...||:|:|:||.:..|..:         |::        :|:::.|:||||.||||
Human   176 DEDIHDQNSKKPVMVYIHGGSYMEGTGN---------MIDGSILASYGNVIVITINYRLGILGFL 231

  Fly   174 SLADEELDVPGNAGLKDQVMALRWVKRNCQFFGGDPDNITVFGESAGGASTHYMMLTDQAKGLFH 238
            |..|:.  ..||.||.||:.||||::.|...|||||..:|:||..||.:....:.|:..::|||.
Human   232 STGDQA--AKGNYGLLDQIQALRWIEENVGAFGGDPKRVTIFGSGAGASCVSLLTLSHYSEGLFQ 294

  Fly   239 KTIIMSGSALAPWAQTPTHINWPYRLAQATGYTGD---ANDRDIFAHLKKCKASSMLKVAEDIIT 300
            |.||.||:||:.||     :|  |:.|:.|....|   .|..|....::..:..:..::.:..||
Human   295 KAIIQSGTALSSWA-----VN--YQPAKYTRILADKVGCNMLDTTDMVECLRNKNYKELIQQTIT 352

  Fly   301 MEERHQRLTMFSFGPTIEPYLTPHCVIPKSPLEMMRDCWGNSIPMVIGGNSFEGLLMFPEVNKWP 365
            ....|     .:|||.|:     ..|||..|..:|......:..:::|.|..|||.....:
Human   353 PATYH-----IAFGPVID-----GDVIPDDPQILMEQGEFLNYDIMLGVNQGEGLKFVDGI---- 403

  Fly   366 ELLCQLGDCENLAPQD------AHVDE-----QQRKAFGKKVRELY--FGDR---TPGRKTILEY 414
                 :.:.:.:.|.|      ..||.     :.:....:.::.:|  :.|:   ...|||::.
Human   404 -----VDNEDGVTPNDFDFSVSNFVDNLYGYPEGKDTLRETIKFMYTDWADKENPETRRKTLVA- 462

  Fly   415 SDLFSYKYFWHGIHRTLLSRAHHAPL-APTFLYRFDFDSKHFNIMRIITCGRKVR----GTCHAD 474
              ||: .:.|  :...:.:...||.. :||:.|.|    .|.       |..:::    .:.|.|
Human   463 --LFT-DHQW--VAPAVATADLHAQYGSPTYFYAF----YHH-------CQSEMKPSWADSAHGD 511

  Fly   475 DLSYLFYNAAAKKLKRRTAEFKTIKRLVSMVV-----HFAISGDPNIPMVCQDEK---EQPRG-- 529
            ::.|:|........:..:..|.....::|.||     :||.:||||.| |.||.|   .:|..
Human   512 EVPYVFGIPMIGPTELFSCNFSKNDVMLSAVVMTYWTNFAKTGDPNQP-VPQDTKFIHTKPNRFE 575

  Fly   530 --AWLPISKDDKVFQCLNISHDVHVIDLPEAEKLRLW 564
              ||...:..|:::  |:|.....|.|...|.|:..|
Human   576 EVAWSKYNPKDQLY--LHIGLKPRVRDHYRATKVAFW 610

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est8	NP_524259.2	COesterase	34..564	CDD:395084	159/620 (26%)
NLGN4X	XP_005274621.1	COesterase	44..610	CDD:395084	159/620 (26%)