DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est8 and NLGN3

DIOPT Version :9

Sequence 1:	NP_524259.2	Gene:	alpha-Est8 / 40899	FlyBaseID:	FBgn0015576	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_851820.1	Gene:	NLGN3 / 54413	HGNCID:	14289	Length:	848	Species:	Homo sapiens

Alignment Length:	657	Identity:	172/657 - (26%)
Similarity:	266/657 - (40%)	Gaps:	184/657 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 LRSNDKVIADTV---YGKVKGVKW---QSIYG--NNYYSFEGIPFAKPPVGELRFKAPVEPEHWS 83
            ||::.:..|.||   :||::|.:.   ..|.|  :.|.   |:|:|.||:||.||..|..|..||
Human    33 LRASTQAPAPTVNTHFGKLRGARVPLPSEILGPVDQYL---GVPYAAPPIGEKRFLPPEPPPSWS 94

  Fly    84 DVKRCTHV---------RAKP---------CQVNIVLKQVQ-GSEDCLYLNVY--TREL------ 121
            .::..||.         .|.|         ..::||...:| .:|||||||||  |.::
Human    95 GIRNATHFPPVCPQNIHTAVPEVMLPVWFTANLDIVATYIQEPNEDCLYLNVYVPTEDVKRISKE 159

  Fly   122 ---HPHRPL--------------------------------PVLVWIYGGGFQMGEASRDLYSPD 151
               .|::.:                                ||:|:|:||.:..|..:
Human   160 CARKPNKKICRKGGSGAKKQGEDLADNDGDEDEDIRDSGAKPVMVYIHGGSYMEGTGN------- 217

  Fly   152 YIMME--------HVVLVVISYRLGALGFLSLADEELDVPGNAGLKDQVMALRWVKRNCQFFGGD 208
              |::        :|:::.::||:|.|||||..|:.  ..||.||.||:.|||||..|..|||||
Human   218 --MIDGSILASYGNVIVITLNYRVGVLGFLSTGDQA--AKGNYGLLDQIQALRWVSENIAFFGGD 278

  Fly   209 PDNITVFGESAGGASTHYMMLTDQAKGLFHKTIIMSGSALAPWAQTPTHINWPYRLAQATGYTGD 273
            |..|||||...|.:....:.|:..::|||.:.||.|||||:.||.....:.:...||...|
Human   279 PRRITVFGSGIGASCVSLLTLSHHSEGLFQRAIIQSGSALSSWAVNYQPVKYTSLLADKVG---- 339

  Fly   274 ANDRDIFAHLKKCKASSMLKVAEDIITMEERHQRLTMFSFGPTIEPYLTPHCVIPKSPLEMMRDC 338
            .|..|....:...:..|..::.|..|.....|     .:|||.|:     ..|||..|..:|...
Human   340 CNVLDTVDMVDCLRQKSAKELVEQDIQPARYH-----VAFGPVID-----GDVIPDDPEILMEQG 394

  Fly   339 WGNSIPMVIGGNSFEGLLMFPEVNKWPELLCQLGDCENLAPQDA------------HVDE----- 386
            ...:..:::|.|..|||.....|               :.|:|.            .||.
Human   395 EFLNYDIMLGVNQGEGLKFVEGV---------------VDPEDGVSGTDFDYSVSNFVDNLYGYP 444

  Fly   387 QQRKAFGKKVRELY--FGDR---TPGRKTILEYSDLFSYKYFWHGIHRTLLSRAHHAPL-APTFL 445
            :.:....:.::.:|  :.||   ...|||::.   ||: .:.|  :..::::...||.. :||:.
Human   445 EGKDTLRETIKFMYTDWADRDNPETRRKTLVA---LFT-DHQW--VEPSVVTADLHARYGSPTYF 503

  Fly   446 YRFDFDSKHFNIMRIITCGRKVR----GTCHADDLSYLFYNAAAKKLKRRTAEFKTIKRLVSMVV 506
            |.|    .|.       |...::    ...|.|::.|:|..............|.....::|.||
Human   504 YAF----YHH-------CQSLMKPAWSDAAHGDEVPYVFGVPMVGPTDLFPCNFSKNDVMLSAVV 557

  Fly   507 -----HFAISGDPNIPMVCQDEK---------EQPRGAWLPISKDDKVFQCLNISHDVHVIDLPE 557
                 :||.:||||.| |.||.|         |:.  ||...:..|:::  |:|.....|.|...
Human   558 MTYWTNFAKTGDPNKP-VPQDTKFIHTKANRFEEV--AWSKYNPRDQLY--LHIGLKPRVRDHYR 617

  Fly   558 AEKLRLW 564
            |.|:..|
Human   618 ATKVAFW 624

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est8	NP_524259.2	COesterase	29..564	CDD:278561	169/653 (26%)
alpha-Est8	NP_524259.2	Aes	<116..>221	CDD:223730	45/155 (29%)
NLGN3	NP_851820.1	COesterase	36..624	CDD:278561	169/652 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	170..195		0/24 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	645..694
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142577
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740