DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est8 and CG10175

DIOPT Version :9

Sequence 1:	NP_524259.2	Gene:	alpha-Est8 / 40899	FlyBaseID:	FBgn0015576	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_001287487.1	Gene:	CG10175 / 42773	FlyBaseID:	FBgn0039084	Length:	707	Species:	Drosophila melanogaster

Alignment Length:	602	Identity:	210/602 - (34%)
Similarity:	306/602 - (50%)	Gaps:	84/602 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 MRIALNYVKFKTNQQRLRSNDKVIADTVYGKVKG--VKWQSIYGNNYYSFEGIPFAKPPVGELRF 73
            ||:....|:      .||...:::|.|..|||:|  .|::|.....||||:|:.:..||.|..||
  Fly   138 MRVVQEVVR------SLRKEREIVATTSLGKVRGRYQKYRSGERGGYYSFKGMRYGAPPTGARRF 196

  Fly    74 KAPVEPEH-WSDVK-------RCTHVRAKPCQVNIVLKQVQGSEDCLYLNVYTREL-----HPHR 125
            :| .|||. ||.::       .|.|       .|::|...:|.||||::||:|.::     ...:
  Fly   197 RA-AEPEKPWSGIRDASREGQSCPH-------KNMILDTFKGDEDCLFVNVFTTQMPKDDESAEQ 253

  Fly   126 P-LPVLVWIYGGGFQMGEASRDLYSPDYIMMEHVVLVVISYRLGALGFLSLADEELDVPGNAGLK 189
            | |||:||::||||..|..:..||.|||::.|.:|||.::||||.||||:...   |.|||.|||
  Fly   254 PKLPVMVWLHGGGFSFGSGNSFLYGPDYLVAEDIVLVTLNYRLGPLGFLTAGP---DAPGNQGLK 315

  Fly   190 DQVMALRWVKRNCQFFGGDPDNITVFGESAGGASTHYMMLTDQAKGLFHKTIIMSGSALAPWAQT 254
            |||:||:||:.|...|||||:.:|:||||||.:|...::|:.|||||||:.|..|||||.||:.:
  Fly   316 DQVLALKWVRDNIAAFGGDPNQVTIFGESAGASSVQLLLLSSQAKGLFHRAISQSGSALNPWSMS 380

  Fly   255 PTHINWPYRLAQATGYTGDANDRDIFAHLKKCKASSMLKVAEDIITMEERHQRLTMFSFGPTI-- 317
            .:......|||...||.|.....||...|::..|..:::.|...||.|::...:.: .|.|.:
  Fly   381 ASSSQRAARLAANLGYVGANKTEDILDFLRRVPAMKLVEAAPTTITAEDQRNNIGL-PFVPVVEG 444

  Fly   318 -------------EPYLTPHCVIPKSPLEMMRDCWGNS-IPMVIGGNSFEGLLMFPEVNKWPELL 368
                         ||:||.|      |.:|......|| :..:.|.|:.|.:|....:.|.|:||
  Fly   445 YWNQDSQEEQFYEEPFLTQH------PSDMYHSQNFNSDVAYMTGYNTHEAMLFIRRLRKNPQLL 503

  Fly   369 CQL-GDCENLAPQDAHVDEQQRKAFGKKVRELYFGDRTPGRKTILEYSDLFSYKYFWHGIHRTLL 432
            ..: .|...|.|||.:|.|...:. .:::|..|.|.:..|.:::.|...|.:...|..||.||
  Fly   504 SIIENDFGRLVPQDLNVTESHDRV-TREIRSFYLGSKHVGIESVDEMIALLTDLMFLQGIRRT-- 565

  Fly   433 SRAHHAPL--APTFLYRFDFDSKHFNIMRIITCGRKVRGTCHADDLSYL----FYNAAAKKLKRR 491
             ..:||..  ||.::|||.||.......|::...|.  |.||.|:|.||    |:|.:   |..:
  Fly   566 -ARNHAKFGNAPVYMYRFSFDGSLGLYKRMLGIPRP--GVCHGDELGYLFKFGFFNLS---LDPK 624

  Fly   492 TAEFKTIKRLVSMVVHFAISGDPNIPMVCQDEKEQP--RGAWLPISKDDKVFQCLN---ISHDVH 551
            :.|.:...|:|.|..:||..|.|.      .:.|.|  ...|.||...: |...||   ||.::.
  Fly   625 SMEVQVKNRMVRMWTNFAKYGSPT------PDSEDPMLTTKWAPIDPTN-VMNSLNYMDISANLA 682

  Fly   552 VIDLPEAEKLRLWDCIY 568
            :...||.|:.|.||.:|
  Fly   683 MKTNPEPERQRFWDEMY 699

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est8	NP_524259.2	COesterase	29..564	CDD:278561	202/578 (35%)
alpha-Est8	NP_524259.2	Aes	<116..>221	CDD:223730	56/110 (51%)
CG10175	NP_001287487.1	COesterase	157..695	CDD:278561	201/571 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	216	1.000	Inparanoid score	I3612
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222591at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	8	7.870