DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est8 and Ace

DIOPT Version :9

Sequence 1:	NP_524259.2	Gene:	alpha-Est8 / 40899	FlyBaseID:	FBgn0015576	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_001163600.1	Gene:	Ace / 41625	FlyBaseID:	FBgn0000024	Length:	649	Species:	Drosophila melanogaster

Alignment Length:	614	Identity:	158/614 - (25%)
Similarity:	260/614 - (42%)	Gaps:	131/614 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 DKVIADTVYGKVKGVKWQSIYGNNYYSFEGIPFAKPPVGELRFKAPVEPEHWSDVKRCTHVRAKP 95
            |:::..|..|.|:| :..::.|...:.:.|||:|||||.:|||:.||..|.|..|...|.:.|..
  Fly    41 DRLVVQTSSGPVRG-RSVTVQGREVHVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDATRLSATC 104

  Fly    96 CQ------------------VNIVLKQVQGSEDCLYLNVYT------------------------ 118
            .|                  .|:       ||||||:||:.
  Fly   105 VQERYEYFPGFSGEEIWNPNTNV-------SEDCLYINVWAPAKARLRHGRGANGGEHPNGKQAD 162

  Fly   119 --RELHPHRP------LPVLVWIYGGGFQMGEASRDLYSPDYI-MMEHVVLVVISYRLGALGFLS 174
              ..:|...|      ||:|:|||||||..|.|:.|:|:.|.: .:.:|::....||:||.|||.
  Fly   163 TDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVASFQYRVGAFGFLH 227

  Fly   175 LADE-----ELDVPGNAGLKDQVMALRWVKRNCQFFGGDPDNITVFGESAGGASTHYMMLTDQAK 234
            ||.|     ..:.|||.||.||.:|:||:|.|...|||:|:.:|:||||||.:|.:..:::...:
  Fly   228 LAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGSSSVNAQLMSPVTR 292

  Fly   235 GLFHKTIIMSGSALAPWAQTPTHINWPYRLAQATGYTGDANDRDIF-----AHLKKCKASSMLKV 294
            ||..:.::.||:..|||    :|:.....:........|.|.....     ||:..|    |..|
  Fly   293 GLVKRGMMQSGTMNAPW----SHMTSEKAVEIGKALINDCNCNASMLKTNPAHVMSC----MRSV 349

  Fly   295 AEDIITMEERHQRLTMFSF--GPTIEPYLTPHCVIPKSPLEMMRDCWGNSIPMVIGGNSFEG--L 355
            ....|::::.:....:.||  .|||:     ...:|..|:.:|:........:::|....||  .
  Fly   350 DAKTISVQQWNSYSGILSFPSAPTID-----GAFLPADPMTLMKTADLKDYDILMGNVRDEGTYF 409

  Fly   356 LMFPEVNKWPELLCQLGDCENLAPQDAHVDEQQRKAFGKKVRELYFGDRTPGRKTILEYSDLFSY 420
            |::..::.:.:      |.....|:|.:::          :....||..|...:..:    :|.|
  Fly   410 LLYDFIDYFDK------DDATALPRDKYLE----------IMNNIFGKATQAEREAI----IFQY 454

  Fly   421 KYFWHG----IHRTLLSRA--HHAPLAPTFLYRFDFDSK-------HFNIMRIITCGRKVRGTCH 472
            . .|.|    .::..:.||  .|....||..|......:       :|......:...:..|..|
  Fly   455 T-SWEGNPGYQNQQQIGRAVGDHFFTCPTNEYAQALAERGASVHYYYFTHRTSTSLWGEWMGVLH 518

  Fly   473 ADDLSYLFYNAAAKKLKRRTAEFKTIKRLVSMVVHFAISGDPNIPMVCQDEKEQPRGAWLPISKD 537
            .|::.|.|.......|:.|..|.:..||::|.|:.||.:|:|     .||.:|     |...||:
  Fly   519 GDEIEYFFGQPLNNSLQYRPVERELGKRMLSAVIEFAKTGNP-----AQDGEE-----WPNFSKE 573

  Fly   538 DKVFQCLNISHDVHVIDL-PEAEKLRLWD 565
            |.|:...:....:..:.. |.|.:...|:
  Fly   574 DPVYYIFSTDDKIEKLARGPLAARCSFWN 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est8	NP_524259.2	COesterase	29..564	CDD:278561	157/611 (26%)
alpha-Est8	NP_524259.2	Aes	<116..>221	CDD:223730	51/142 (36%)
Ace	NP_001163600.1	COesterase	41..601	CDD:278561	157/611 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440442
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840