DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est8 and alpha-Est3

DIOPT Version :9

Sequence 1:	NP_524259.2	Gene:	alpha-Est8 / 40899	FlyBaseID:	FBgn0015576	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_001163540.1	Gene:	alpha-Est3 / 40907	FlyBaseID:	FBgn0015571	Length:	543	Species:	Drosophila melanogaster

Alignment Length:	541	Identity:	240/541 - (44%)
Similarity:	334/541 - (61%)	Gaps:	18/541 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 DTVYGKVKGVKWQSIYGNNYYSFEGIPFAKPPVGELRFKAPVEPEHWSDVKRCTHVRAKPCQVNI 100
            :|..|.|.|.:...:||:.|.|||.||:|:||||.|||.||:..|.||....||....||.|.|.
  Fly     7 NTTSGPVLGKQCTGVYGDEYVSFERIPYAQPPVGHLRFMAPLPVEPWSQPLDCTKPGQKPLQFNH 71

  Fly   101 VLKQVQGSEDCLYLNVYTRELHPHRPLPVLVWIYGGGFQMGEASRDLYSPDYIMMEHVVLVVISY 165
            ..||::|.|||||||||.:||...||||::|:.:||||:.|:.:::|:||||.||..||:|.:||
  Fly    72 YSKQLEGVEDCLYLNVYAKELDSPRPLPLIVFFFGGGFEKGDPTKELHSPDYFMMRDVVVVTVSY 136

  Fly   166 RLGALGFLSLADEELDVPGNAGLKDQVMALRWVKRNCQFFGGDPDNITVFGESAGGASTHYMMLT 230
            |:|.||||||.|..:.||||||||||::|:.|:|.|.:.|.|||.|:|.||||||.||.||:||.
  Fly   137 RVGPLGFLSLNDPAVGVPGNAGLKDQLLAMEWIKENAERFNGDPKNVTAFGESAGAASVHYLMLN 201

  Fly   231 DQAKGLFHKTIIMSGSALAPWAQTPTHINWPYRLAQATGYTG--DANDRDIFAHLKKCKASSMLK 293
            .:|:|||||.|:.||:.|..||.. |..|.|:|||...|...  ...|..:...|:|....   |
  Fly   202 PKAEGLFHKAILQSGNVLCSWALC-TIKNLPHRLAVNLGMESAEHVTDAMVLDFLQKLPGE---K 262

  Fly   294 VAEDIITMEERHQRLTMFSFGPTIEPYLTPHCVIPKSPLEMMRDCWGNSIPMVIGGNSFEGLLMF 358
            :....:...|.|....:|.|||.:|||.|.||.:|..|.|::...|||.||:::.|.|||||||:
  Fly   263 LVRPYLLSAEEHLDDCVFQFGPMVEPYKTEHCALPNHPQELLDKAWGNRIPVLMSGTSFEGLLMY 327

  Fly   359 PEVNKWPELLCQL-GDCENLAPQDA--HVDEQQRKAFGKKVRELYFGDRTPGR---KTILEYSDL 417
            ..|...|.||..| .:.|::.|.|.  ::.:...:..|::::|.:||...|..   :::..|.:.
  Fly   328 ARVQMAPYLLTSLKKEPEHMLPLDVKRNLPQALARHLGQRLQETHFGGNDPSAMSPESLKAYCEY 392

  Fly   418 FSYKYFWHGIHRTLLSRAHHAPLAPTFLYRFDFDSKHFNIMRIITCGRKVRGTCHADDLSYLFYN 482
            .|||.|||.|.:||.||...:. |.|:||||||||..||..|:..||.|:||..|.||.|||:|.
  Fly   393 ASYKVFWHPILKTLRSRVKSSS-ASTYLYRFDFDSPTFNHQRLKYCGDKLRGVAHVDDHSYLWYG 456

  Fly   483 AAAKKLKRRTAEFKTIKRLVSMVVHFAISGDPNIPMVCQDEKEQPRG-AWLPISKDDKVFQCLNI 546
            ..:.||.:.|.||.||:|::.|:..||.:.:||..:: ||  :.||. .|.|:: .....:||||
  Fly   457 DFSWKLDKHTPEFLTIERMIDMLTSFARTSNPNCKLI-QD--QLPRAKEWKPLN-SKSALECLNI 517

  Fly   547 SHDVHVIDLPEAEKLRLWDCI 567
            |.::.:::|||.:|||:|:.:
  Fly   518 SENIKMMELPELQKLRVWESV 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est8	NP_524259.2	COesterase	29..564	CDD:278561	239/536 (45%)
alpha-Est8	NP_524259.2	Aes	<116..>221	CDD:223730	60/104 (58%)
alpha-Est3	NP_001163540.1	Abhydrolase	3..529	CDD:304388	235/530 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467356
Domainoid	1	1.000	222	1.000	Domainoid score	I1478
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	226	1.000	Inparanoid score	I2231
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR43142
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	8	7.890