DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est8 and alpha-Est6

DIOPT Version :9

Sequence 1:	NP_524259.2	Gene:	alpha-Est8 / 40899	FlyBaseID:	FBgn0015576	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_524262.1	Gene:	alpha-Est6 / 40902	FlyBaseID:	FBgn0015574	Length:	568	Species:	Drosophila melanogaster

Alignment Length:	555	Identity:	232/555 - (41%)
Similarity:	320/555 - (57%)	Gaps:	43/555 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 SNDKVIADTVYGKVKGVKWQSIYGNNYYSFEGIPFAKPPVGELRFKAPVEPEHWSDVKRCTHVRA 93
            ::.||:..:| |.|||.:...|||:.:||||||||||||:|:.||.|....:.|:........|.
  Fly    38 ADSKVVKLSV-GSVKGRRLSGIYGDEFYSFEGIPFAKPPLGKARFVASQLADPWNSELDARQERP 101

  Fly    94 KPCQVNIVLKQVQGSEDCLYLNVYTRELHPHR-PLPVLVWIYGGGFQMGEASRDLYSPDYIMMEH 157
            .|.|::....:|.||||||||||||:..:... ||||:|:||||.|:.|.|.:..|.|||:|...
  Fly   102 IPLQMDRRSGKVVGSEDCLYLNVYTKHFNESEPPLPVMVYIYGGAFRTGGAVKSKYGPDYLMSRD 166

  Fly   158 VVLVVISYRLGALGFLSLADEELDVPGNAGLKDQVMALRWVKRNCQFFGGDPDNITVFGESAGGA 222
            ||.|:.:|||.:|||||:...:|||||||||.||::||:||.::.:.|.|||.|||:||||||.|
  Fly   167 VVYVLFNYRLCSLGFLSMPSGKLDVPGNAGLHDQLLALQWVSQHIRNFNGDPQNITLFGESAGAA 231

  Fly   223 STHYMMLTDQAKGLFHKTIIMSGSALAPWAQTPTHINWPYRLAQATGYTGDANDRDIFAHLKKCK 287
            |.|:||...||||||||.|:||||.|:||...|.......|||.:.||.|.|.:..|...|:...
  Fly   232 SVHFMMCLPQAKGLFHKAIMMSGSMLSPWVNAPDSDGIFCRLATSAGYEGPAEEVPILEFLRNVN 296

  Fly   288 ASSMLKVAEDIITMEERHQRLTMFSFGPTIEPYLTPHCVIPKSPL-EMMRDCWGNSIPMVIGGNS 351
            |..:  :..|.|:..:|     .|.|   :.|:......:..:|. ::|::.|...:|:::||.|
  Fly   297 AEKL--IGHDFISPRDR-----CFGF---LNPFAPVVGGLVAAPFQQLMKEAWSCEVPLLLGGTS 351

  Fly   352 FEGLLMFPEVNKWPELLCQLGD---CENLAPQDAHV---------DEQQRKAFGKKVRELYFGDR 404
            ||||:.:|        .|||.:   .|.|..:.|.|         ..::|......:.:.::|.|
  Fly   352 FEGLVYYP--------FCQLDNGYMLELLKHEPAMVLPHELYQSMSVEERNTAADVLVKYHYGPR 408

  Fly   405 TPGRKTILEYSDLFSYKYFWHGIHRTLLSRAHHAPLAPTFLYRFDFDSKHFNIMRIITCGRKV-R 468
            ...:..|.:..||||||.|||||||.:|||..||. |||:||||||||...|:||...||..: |
  Fly   409 GITKSNITQILDLFSYKLFWHGIHRVVLSRLSHAQ-APTYLYRFDFDSPKLNLMRNQLCGDDIKR 472

  Fly   469 GTCHADDLSYLFYNAAAKKLKRRTAEFKTIKRLVSMVVHFAISGDPNIPMVCQDEKEQPRGAWLP 533
            |.||||||.|:|:..|..|....:.||.||:|:|.::..||.:||||.|....|       .|:|
  Fly   473 GVCHADDLGYIFHKQAQAKQPLDSPEFLTIQRMVGILTTFARTGDPNCPETGPD-------PWMP 530

  Fly   534 ISKDDKVFQCLNISHDVHVIDLPEAEKLRLWDCIY 568
            :|.... |:.|||...|..:...|.:.|::|:.:|
  Fly   531 VSTKSP-FKALNIGQQVECVTQVEKDGLKVWNRLY 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est8	NP_524259.2	COesterase	29..564	CDD:278561	230/549 (42%)
alpha-Est8	NP_524259.2	Aes	<116..>221	CDD:223730	58/105 (55%)
alpha-Est6	NP_524262.1	COesterase	35..534	CDD:278561	223/522 (43%)
alpha-Est6	NP_524262.1	Aes	<133..325	CDD:223730	94/201 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467370
Domainoid	1	1.000	222	1.000	Domainoid score	I1478
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	226	1.000	Inparanoid score	I2231
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D8477at33392
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR43142
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	10	9.900