DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est8 and alpha-Est10

DIOPT Version :9

Sequence 1:	NP_524259.2	Gene:	alpha-Est8 / 40899	FlyBaseID:	FBgn0015576	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_001246962.1	Gene:	alpha-Est10 / 40896	FlyBaseID:	FBgn0015569	Length:	581	Species:	Drosophila melanogaster

Alignment Length:	556	Identity:	264/556 - (47%)
Similarity:	372/556 - (66%)	Gaps:	18/556 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 VKFKTNQQRLRSNDKVIADTVYGKVKGVKWQSIYGNNYYSFEGIPFAKPPVGELRFKAPVEPEHW 82
            :.||..|::|.:....:..|..|.|:|||..:|:|.:|:|||.|||||||||:||||||...|.|
  Fly    34 ISFKYEQRKLSTAIYSVIKTKSGPVRGVKRNTIWGGSYFSFEKIPFAKPPVGDLRFKAPEAVEPW 98

  Fly    83 SDVKRCTHVRAKPCQVNIVLKQVQGSEDCLYLNVYTRELHPHRPLPVLVWIYGGGFQMGEASRDL 147
            .....||....||.|.::..::..|||||||||||.::|.|.:..||:|||||||:|:||||||:
  Fly    99 DQELDCTSPADKPLQTHMFFRKYAGSEDCLYLNVYVKDLQPDKLRPVMVWIYGGGYQVGEASRDM 163

  Fly   148 YSPDYIMMEHVVLVVISYRLGALGFLSLADEELDVPGNAGLKDQVMALRWVKRNCQFFGGDPDNI 212
            ||||:.|.:.||:|.::|||||||||||.|.:|:||||||||||:||||||::|.:.||||.:||
  Fly   164 YSPDFFMSKDVVIVTVAYRLGALGFLSLDDPQLNVPGNAGLKDQIMALRWVQQNIEAFGGDSNNI 228

  Fly   213 TVFGESAGGASTHYMMLTDQAKGLFHKTIIMSGSALAPWAQTPTHINWPYRLAQATGYTGDANDR 277
            |:|||||||||||::.|:.|.:||.||.|:||||.|.||.|.|.: ||.|||||..|||||..|:
  Fly   229 TLFGESAGGASTHFLALSPQTEGLIHKAIVMSGSVLCPWTQPPRN-NWAYRLAQKLGYTGDNKDK 292

  Fly   278 DIFAHLKKCKASSMLKVAEDIITMEERHQRLTMFSFGPTIEPYLTPHCVIPKSPLEMMRDCWGNS 342
            .||..|:......::|....:::.:|:|.|: :|:|||.:|||.|.|.|:.|.|.|:|::.|.:.
  Fly   293 AIFEFLRSMSGGEIVKATATVLSNDEKHHRI-LFAFGPVVEPYTTEHTVVAKQPHELMQNSWSHR 356

  Fly   343 IPMVIGGNSFEGLLMFPEVNKWPELLCQLGDCENLAPQD--AHVDEQQRKAFGKKVRELYFGDRT 405
            |||:.||.||||||.:|||::.|..|.::|:|:||.|.|  .::|.:.|:.:|.::::.||||..
  Fly   357 IPMMFGGTSFEGLLFYPEVSRRPATLDEVGNCKNLLPSDLGLNLDPKLRENYGLQLKKAYFGDEP 421

  Fly   406 PGRKTILEYSDLFSYKYFWHGIHRTLLSRAHHAPLAPTFLYRFDFDSKHFNIMRIITCGRKVRGT 470
            ..:..::::.:|.||:.|||.|:|..|:|...:. |||:|||||.|||..|.:||:.||.::||.
  Fly   422 CNQANMMKFLELCSYREFWHPIYRAALNRVRQSS-APTYLYRFDHDSKLCNAIRIVLCGHQMRGV 485

  Fly   471 CHADDLSYLFYNAAAKKLKRRTAEFKTIKRLVSMVVHFAISGDPNIPMVCQDEKEQPRGAWLPIS 535
            ||.|||.|:|::..:.:....:.|.|.|..:|.:...||..||||    |:..|.      |..:
  Fly   486 CHGDDLCYIFHSMLSHQSAPDSPEHKVITGMVDVWTSFAAHGDPN----CESIKS------LKFA 540

  Fly   536 KDDKV--FQCLNISHDVHVIDLPEAEKLR-LWDCIY 568
            ..:.|  |:||||.....|:.|||.:|:. :|:..|
  Fly   541 PIENVTNFKCLNIGDQFEVMALPELQKIEPVWNSFY 576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est8	NP_524259.2	COesterase	29..564	CDD:278561	258/539 (48%)
alpha-Est8	NP_524259.2	Aes	<116..>221	CDD:223730	70/104 (67%)
alpha-Est10	NP_001246962.1	COesterase	49..542	CDD:278561	247/505 (49%)
alpha-Est10	NP_001246962.1	Aes	<132..>279	CDD:223730	95/147 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467338
Domainoid	1	1.000	450	1.000	Domainoid score	I1603
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	492	1.000	Inparanoid score	I3113
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG26273
OrthoDB	1	1.010	-	-		D18817at7147
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR43142
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	11	10.910