DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est8 and CG10339

DIOPT Version :9

Sequence 1:	NP_524259.2	Gene:	alpha-Est8 / 40899	FlyBaseID:	FBgn0015576	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_611881.1	Gene:	CG10339 / 37854	FlyBaseID:	FBgn0034972	Length:	603	Species:	Drosophila melanogaster

Alignment Length:	615	Identity:	146/615 - (23%)
Similarity:	235/615 - (38%)	Gaps:	164/615 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 GKVKGVKWQSIYGNNYYSFEGIPFA-----KPPVGELR-----FKAPV-EPEHWSDVKRCTHVRA 93
            |.:.|...:.....|..::.||.:|     :||..||.     |.|.| :|:.|.:        |
  Fly    40 GVISGTYLKMFRTQNIKAYLGIRYAHARRFQPPDIELTPWKGIFNATVFQPDCWQN--------A 96

  Fly    94 KPC---QVNIVLKQVQG-----------SEDCLYLNVYTRELHPH-RPLPVLVWIYGGGFQMGEA 143
            .|.   :...:||.:|.           .|:||||||:..:..|. ....|:|||:.|.|..|..
  Fly    97 MPSVGKETEQILKIIQSDSSAQDAERKYEENCLYLNVFVPDGLPEINGYAVVVWIHSGDFSTGSP 161

  Fly   144 SRDLYSPDYIMMEHVVLVVISYRLGALGFLSLADEELDVPGNAGLKDQVMALRWVKRNCQFFGGD 208
            : |:.....:..:.|::|..||||...||.:..|.|  ..||.||.||..||.|||:|..|||||
  Fly   162 A-DVEPFQLVFKQKVIVVTFSYRLNIFGFFTTDDGE--AQGNYGLMDQSAALYWVKKNINFFGGD 223

  Fly   209 PDNITVFGESAGGASTHYMMLTDQ-AKGLFHKTIIMSGSALAPWAQTPTHINWPYRLAQATGYTG 272
            .:.||:.|..||..|....|.:.: :||.|||.|||||:.|:.       :..||.      |.|
  Fly   224 SNRITLMGHDAGAVSVALHMTSGEWSKGGFHKAIIMSGNPLST-------VKMPYE------YEG 275

  Fly   273 DAND-RDIFAHLKKC--KASSMLKVAEDIITMEERHQRLTMFSFGPTIEPYL--TPHCVIPKSPL 332
            ..:. ...||    |  :.:||.......|..:...:.|...|:||.::..|  |.:..|...|.
  Fly   276 SLDQVSSTFA----CPRRPTSMFIQCLKRIDAKRLSENLPQVSWGPVVDFGLSNTSYPFIENQPE 336

  Fly   333 EMMRDCWGNSIPMVIGGNSFEGLLMFPEVNKWPELLCQLGDCE----NLAPQDAHVDEQQRKAFG 393
            .:.:....:.:|::||....|.:|...:.|...::  ...|.|    ::|..|.|
  Fly   337 ILFKKGSYHRVPVIIGVTDMEEVLTLFKDNLDTDI--SPSDLEGFYTDIAVTDMH---------- 389

  Fly   394 KKVRE----------------LYFGDR-TPGRKT----------------ILEYSDLFS-----Y 420
            |.||.                :|..|. |..:|.                :..::||.|     |
  Fly   390 KLVRNYEWCSNYELISDAINFMYANDSDTDAKKANKHIISAHTEKFYITPMQTFADLISNDSQVY 454

  Fly   421 KYFWHGIHRTLLSRAHHAPLAPTFLYRFDFDS-----KHFNIMRIITCGRKVRGTCHADDLSYLF 480
            .|.:....|::|.               |..|     |:|:  :|...|.           .|:.
  Fly   455 SYLFRMRPRSVLQ---------------DLPSWISVPKYFD--QIFVWGN-----------PYMT 491

  Fly   481 YNAAAKKLKRRTAEFKTIKRLVSMVVHFAISGDPNIPMVCQDEKEQPRGAWLPIS-KDDKVFQCL 544
            .:...|...::.|:.     ::::..:||.:.:|.        |......|..:: .:|.|   |
  Fly   492 NSVDWKSTDKKIADI-----IMTLWANFAKTSNPT--------KSNVYVKWNAMTPNNDSV---L 540

  Fly   545 NISHDVHVIDLPEAEKLRLWDCIYDRELLY 574
            .|....:..:|...:::..|..:|.:.|::
  Fly   541 LIDESFNTDNLLNNQRINFWRSLYPKILVF 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est8	NP_524259.2	COesterase	29..564	CDD:278561	143/603 (24%)
alpha-Est8	NP_524259.2	Aes	<116..>221	CDD:223730	41/105 (39%)
CG10339	NP_611881.1	COesterase	30..560	CDD:278561	143/603 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	4	3.810