DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est8 and CG12869

DIOPT Version :9

Sequence 1:	NP_524259.2	Gene:	alpha-Est8 / 40899	FlyBaseID:	FBgn0015576	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_001369085.1	Gene:	CG12869 / 36616	FlyBaseID:	FBgn0033943	Length:	839	Species:	Drosophila melanogaster

Alignment Length:	592	Identity:	145/592 - (24%)
Similarity:	232/592 - (39%)	Gaps:	108/592 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 YVKFKTNQQRLRSND----KVIADTVYGKVKGVKWQSIYGNNYYSFEGIPFAKPPVGELRFKAPV 77
            |:..:....:|...|    ||..|...|.|             |:|.|||:|:.|:.|||| ||.
  Fly    23 YISAQQTHIKLEQGDLIGLKVFPDGTRGAV-------------YAFLGIPYAQAPINELRF-APA 73

  Fly    78 EPEHWSDVKRCTHVRAK----PCQVNIVL---------KQVQGSEDCLYLNVYTREL-HPHRPLP 128
            :|.  |...|.......    |...|.:.         :.|...|||||||::|.|. ..:..||
  Fly    74 KPS--SSFNRTLQATTMQPLCPQLANTIYDESSDGSMPRSVSTDEDCLYLNIWTPESGMRYGKLP 136

  Fly   129 VLVWIYGGGFQMGEASRDLYSPDYIMMEHVVLVVISYRLGALGFLSLADEELDVPGNAGLKDQVM 193
            ::|.:.|..|........:...| :..|.:|:|.:.||....|:|||.::..:||||.||.|..|
  Fly   137 IVVIVTGEEFAYDWPRNRINGLD-LAGEGIVVVSVQYRNNIYGWLSLGEQHRNVPGNYGLSDVQM 200

  Fly   194 ALRWVKRNCQFFGGDPDNITVFGESAGGASTHYMMLTDQAKGLFHKTIIMSGSALAPWAQTPTHI 258
            ||||::||...|||:||:||:.|..:|||....:...:.:..:....::..|..:....|  .|.
  Fly   201 ALRWIRRNADAFGGNPDHITLLGHGSGGAPLALVATLEDSSQVKQLVLMSPGPIMRALGQ--NHQ 263

  Fly   259 NWPYR----LAQATG-YTGDANDRDIFAHLKKCKASSMLKVAEDIITMEERHQRLTMFSFGPTIE 318
            .|...    |.|..| ...:|..|.:...|::.....:|:..|.:........:|.:
  Fly   264 KWIVETGQVLVQKLGCQFEEAQRRQLMGCLRRKSREDLLRAYESVYNHGNGSSQLGV-------- 320

  Fly   319 PYLTPHCVIPKS-PLEM-MRDCWGNSIPMVIGGNSFEGLLM---FPEVNKWPELLCQLGDCENLA 378
                   ::|:. |||. :|:  ....|:::|..|.||..:   :.:|.:..::.........|.
  Fly   321 -------ILPEGLPLEQRLRN--KTLPPVLLGITSNEGAFLQDYWLDVAREGQVALHKYINHTLL 376

  Fly   379 PQDAH----VDEQQRKAFGKKVRELYFGDRTPGRKTILEYSDLFSYKYFWHGIHRTLLSRAHHAP 439
            |....    |.|:...... .:|..||..:..|...:|.            |:.|.|....:..|
  Fly   377 PNVMRALESVGEESSTQLA-AIRWRYFNGKGEGVSHLLA------------GMQRLLSESLYELP 428

  Fly   440 -------LAPTFLYRFDFDSKHFNIMRIITCGRK--VRGTCHADDLSYLFYNAAAKKLKRRT--- 492
                   |..|..|.:.||..|...||    ||:  ..|..|:.||..|...:..:::.||.
  Fly   429 YSRILELLNGTTSYAYVFDHSHSMDMR----GRRNLFGGASHSSDLPLLLGPSLFQQIARRRFSG 489

  Fly   493 AEFKTIKRLVSMVVHFAISGDPNIPMVCQDEKEQPRGAWLPISKDDKVFQCLN---ISHDVHVID 554
            .|.:..:::.....:|..:|:|. |....|       .|||.:|::.....|.   .:.....:|
  Fly   490 EEEQLCRKIRGAFANFIKNGNPT-PGRIYD-------GWLPYNKENPFVYSLGEQAKTPQTGSVD 546

  Fly   555 LPEAEKL 561
            ..|.:||
  Fly   547 EAEVDKL 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est8	NP_524259.2	COesterase	29..564	CDD:278561	143/580 (25%)
alpha-Est8	NP_524259.2	Aes	<116..>221	CDD:223730	39/105 (37%)
CG12869	NP_001369085.1	COesterase	27..541	CDD:395084	140/574 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810