DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est8 and CG3841

DIOPT Version :9

Sequence 1:	NP_524259.2	Gene:	alpha-Est8 / 40899	FlyBaseID:	FBgn0015576	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_001188759.1	Gene:	CG3841 / 34278	FlyBaseID:	FBgn0032131	Length:	564	Species:	Drosophila melanogaster

Alignment Length:	518	Identity:	153/518 - (29%)
Similarity:	235/518 - (45%)	Gaps:	88/518 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 DKVIADTVYGKVKGVKWQSIYGNNYYSFEGIPFAKPPVGELRFKAPVEPEHWSD-VKRCTH---V 91
            |..:.:...|:::|...||......|:|.||.:|:.|||:|||..||....|.| |...|.   |
  Fly    27 DDPVVELSLGRIQGDTMQSFGNKTIYAFRGIRYAQSPVGQLRFANPVPETSWGDEVFNATSDSLV 91

  Fly    92 RAKPCQVNIVLKQVQGSEDCLYLNVYTRELHPHRPLPVLVWIYGGGFQMGEASRDLYS-PDYIMM 155
            ..:|..|:::      |||||.:||:|:....  ..||:|:|:||...:|.......: |.|::.
  Fly    92 CPQPGVVSLM------SEDCLKINVFTKSFED--KFPVMVYIHGGANVLGSGHSSYEAGPQYLLD 148

  Fly   156 EHVVLVVISYRLGALGFLSLADEELDVPGNAGLKDQVMALRWVKRNCQFFGGDPDNITVFGESAG 220
            :.||.|..:||||||||||....|  ..||.|..||||||.||:.:...|||||:.:|:.|.|||
  Fly   149 QDVVFVAFNYRLGALGFLSTNSSE--TKGNFGFLDQVMALEWVRDHISHFGGDPELVTIIGISAG 211

  Fly   221 GASTHYMMLTDQAKGLFHKTIIMSGSALAPWAQTPTHIN-----WPYRLAQATG---YTGDANDR 277
            ..:....:.:..:.||||:.|:|||||       ..|.:     |..:||:..|   |  |..|
  Fly   212 SMAVSLHLASPLSAGLFHRAILMSGSA-------TNHFDIDNLFWTRKLARELGCPMY--DPTD- 266

  Fly   278 DIFAHLKKCKASSMLKVAEDIITMEERHQRLTMFSFGPTIEPYLTPHCVIPKSPLEMMRDCWGNS 342
                 :.:|..:.......::....|.:|.:.| .:...|:.:.     :...|.|::::...|.
  Fly   267 -----VVECLRNETWTRIVEVCKAWETYQLVNM-KWNYEIDGHF-----LHNHPTELIKEGNFNK 320

  Fly   343 IPMVIG--GNSFEG-----------LLMFPE--VNKWPELLCQLGDCENLAPQDAHVDEQQRKAF 392
            :|::|.  .|.|:.           |..|..  |:..|||.        |...||.:
  Fly   321 VPLLISFTANEFDYNANVHLENQHLLHDFASNFVDYAPELF--------LYRHDAQI-------- 369

  Fly   393 GKKVRELYFGDRTP--GRKTILEYSDLFSYKYFWHGIHRTLLSRAHHAPLAPTFLYRFDFDSKHF 455
            |:|:::.|.||.|.  ..:.|..:..:||..|..||:|| |:..|.|  ..|.:..|.|:....
  Fly   370 GEKLKDFYLGDNTTEINSENIENFGQIFSDAYIGHGVHR-LVQLASH--FTPVYYTRMDYVGDQ- 430

  Fly   456 NIMRIITCGRKVRGTCHADDLSYL----FYNAAAKKLKRRTAEFKTIKRLVSMVVHFAISGDP 514
            ::...:....|..|..|||||.|:    :|...   :....::...::||.|...|||.:|.|
  Fly   431 SLSAPLNGENKPVGVGHADDLHYVLPGYWYGPL---MAANDSDVFMMERLTSWFTHFAKTGTP 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est8	NP_524259.2	COesterase	29..564	CDD:278561	153/518 (30%)
alpha-Est8	NP_524259.2	Aes	<116..>221	CDD:223730	45/105 (43%)
CG3841	NP_001188759.1	COesterase	27..528	CDD:278561	153/518 (30%)
CG3841	NP_001188759.1	Aes	<116..>235	CDD:223730	49/122 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467390
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D40835at6656
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR43142
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	10	9.900