DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est8 and CG9287

DIOPT Version :9

Sequence 1:	NP_524259.2	Gene:	alpha-Est8 / 40899	FlyBaseID:	FBgn0015576	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_609244.1	Gene:	CG9287 / 34194	FlyBaseID:	FBgn0032057	Length:	625	Species:	Drosophila melanogaster

Alignment Length:	534	Identity:	150/534 - (28%)
Similarity:	218/534 - (40%)	Gaps:	109/534 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 TVYGKVKGVKWQSIYGNNYYSFEGIPFAKPPVGELRFKAPVEPEHWSDVKRCTHVR-AKPCQVNI 100
            ::.||:....|..   .....|..:.:|:||.|..|||||...|.|.||...|..: ..|..|::
  Fly    43 SIQGKILETAWTK---REVLQFVDVRYAEPPTGLHRFKAPRPIEPWEDVMDATAEKIGCPSVVSM 104

  Fly   101 ----VLKQVQGSEDCLYLNVYTRELHPHRPLPVLVWIYGGGFQMGEASRDLYSPDYIMMEHVVLV 161
                .|..|...||||.:.:.|..:...  |||||:|:|.  .:.|.|.....|||::.:.||||
  Fly   105 DSLRRLDDVLDVEDCLTMTITTPNVTSR--LPVLVYIHGE--YLYEGSNSEAPPDYLLEKDVVLV 165

  Fly   162 VISYRLGALGFLSLADEELDVPGNAGLKDQVMALRWVKRNCQFFGGDPDNITVFGESAGGASTHY 226
            ...||||..||||...:|  :|||||..|..:||::||...::|||||..:||.|:..|.|..|.
  Fly   166 TPQYRLGPFGFLSTKTDE--IPGNAGFLDIFLALQFVKHFIKYFGGDPSRVTVAGQVGGAAIAHL 228

  Fly   227 MMLTDQA-KGLFHKTIIMSGSALAPWAQTPTHINWPYRLAQATGYTGD---ANDRDIFAHLKKCK 287
            :.|:... :||||:.|..||||:.|......    |.:.||......|   ...||:...|.:..
  Fly   229 LTLSPVVQRGLFHQVIYHSGSAIMPIFLEED----PRKHAQEIAKKADCKMVTVRDLNTCLMELT 289

  Fly   288 ASSMLKV-AEDIITMEE---RHQRLTMFSFGPTIEPYLTPHCVIPKSPLEMMRD----------C 338
            |..:|.. .|..:...:   .|.....|:.|       .|..|:||.|.::|.:          |
  Fly   290 ALELLTAFMEHALEKSDLGIGHTGGIQFTIG-------GPSGVLPKHPYDLMLETNFSYPAMGGC 347

  Fly   339 WGNSIPMVIG---GNSFEGLLMFPEVNKWPELLCQLGDCENLAPQDAHVDEQQRKAFGKKVRELY 400
            ..|:...|:.   .|.|||.:...|.|.:                 .::|...|:..|..
  Fly   348 PKNAGSRVLNEIVDNDFEGKIPDDEYNTY-----------------NYIDHVIRQTVGTD----- 390

  Fly   401 FGDRTPGRKTILEYS----DLFSYKYFWHGIHRTLLSRA--------HHAPLA------------ 441
                    ||:|..|    |.|:.....:|...||:.|.        |..|:.
  Fly   391 --------KTMLLTSFVTHDFFNRNLMENGTFDTLIPRLIDVAGTLNHKLPVLLALNMNNKHNPD 447

  Fly   442 PTFLYRFDFDSKHFNIMRIITCGRKVR-----GTCHADDLSYLF-YNAAAKKLKRRTAEFKTIKR 500
            .||||.||: :..||..:.:.....::     |....|:..||| |.....:|.|  .:.....|
  Fly   448 NTFLYSFDY-AGEFNRYKEMDEETNLQSPFKAGVSLTDEALYLFPYPEHVTRLSR--PDQSMAHR 509

  Fly   501 LVSMVVHFAISGDP 514
            :|.:..:|.|||:|
  Fly   510 MVELWTNFVISGNP 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est8	NP_524259.2	COesterase	29..564	CDD:278561	150/534 (28%)
alpha-Est8	NP_524259.2	Aes	<116..>221	CDD:223730	44/104 (42%)
CG9287	NP_609244.1	COesterase	31..558	CDD:278561	150/534 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467455
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR43142
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.890