DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est8 and cel.1

DIOPT Version :9

Sequence 1:	NP_524259.2	Gene:	alpha-Est8 / 40899	FlyBaseID:	FBgn0015576	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_955901.2	Gene:	cel.1 / 322481	ZFINID:	ZDB-GENE-030131-1201	Length:	550	Species:	Danio rerio

Alignment Length:	560	Identity:	166/560 - (29%)
Similarity:	256/560 - (45%)	Gaps:	78/560 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 GKVKGVKWQSIYGNNYY-SFEGIPFAKPPVGELRFKAPVEPEHWSDVKRCTHVRAKPCQVNIVLK 103
            |.|:| |.:|:....|. :|:|||||.||   .||:.||....|..|.:.|..|.:..|:|::..
Zfish    30 GMVQG-KSRSVGLFRYMDTFKGIPFAAPP---KRFEKPVAHPGWEGVLKTTDYRKRCLQLNLLAT 90

  Fly   104 QVQGSEDCLYLNVYT---RELHPHRPLPVLVWIYGGGFQMGEASRDLYSPDYI-----MME--HV 158
            .|.|||||||||::.   |.:..:  |||:|:||||.|.:|......:..:|:     |.:  :|
Zfish    91 DVIGSEDCLYLNIWVPQGRTVSSN--LPVMVFIYGGAFLLGGGQGANFLDNYLYDGEEMADRGNV 153

  Fly   159 VLVVISYRLGALGFLSLADEELDVPGNAGLKDQVMALRWVKRNCQFFGGDPDNITVFGESAGGAS 223
            ::|..:||:|||||:|..|:  .:|||.||.||..|:.||.||.:.|||:|||||:||||||.||
Zfish   154 IVVTFNYRVGALGFMSTGDD--GIPGNYGLWDQHAAISWVHRNIKAFGGNPDNITLFGESAGAAS 216

  Fly   224 THYMMLTDQAKGLFHKTIIMSGSALAPWAQTPTHINWPYRLAQATGYTGDANDRDIFAHLKKCKA 288
            .::.::|.:.||:..:.|..||.||.|||.:.....:...:|...|...|:...|.   ||:...
Zfish   217 VNFQIITPKNKGMIRRAISQSGVALCPWAISRNPRQFAEEIATKVGCPIDSGMADC---LKRADP 278

  Fly   289 SSMLKVAEDIITMEERHQRLTMFSFGPTIEP-YLTPHC---VIPKSPLEMMRDCWGNS--IPMVI 347
            .:        :|:..: .:||.....|.:.. ||:|..   .||..|    ...:||:  |..:.
Zfish   279 KA--------VTLAGK-LKLTSSPDAPIVHNLYLSPVIDGDFIPDEP----ETLFGNAADIDYIA 330

  Fly   348 GGNSFEGLLM----FPEVNKWPELLCQLGDCENLAP-------QDAHVDEQQRKAFGKKVRELYF 401
            |.|..:..:.    .|.:|. ......:.:.:.||.       |||.:...|...       :.:
Zfish   331 GVNDMDAHIFATIDIPSINN-ALTTTPVEEVQALATALSRDRGQDAGIATFQEYT-------VNW 387

  Fly   402 GDRTPGRKTILEYSDLFSYKYFWHGIHRTLLSRAHHAPLAPTFLYRFDFDSKHFNIMRIITCGRK 466
            ||:....|......:|.:...|.......|.....:|..|.||.|.|...|:       |.....
Zfish   388 GDKPNKEKVKQTVVELETDYMFLVPTQAALYLHTDNAKSARTFSYLFTESSR-------IPVFPL 445

  Fly   467 VRGTCHADDLSYLFYNAAAKKLKRRTAEFKTIKRLVSMVVHFAISGDPNIPMVCQDEKEQPRGAW 531
            ..|..|||:|.|:|....|..|..........|.:::...:||.:||||     :.|.:.| ..|
Zfish   446 WMGADHADELQYVFGKPFATPLGYFPRHRDVSKYMIAYWSNFAQTGDPN-----KGESKVP-VTW 504

  Fly   532 LPISKDDKVFQCLNISHDVHVIDLPEAEKLRL---WDCIY 568
            ...|...  .|.|:|::.::..::.:..:.||   |..::
Zfish   505 PEFSNPG--HQYLDINNKMNKNNVKQMLRTRLVYYWTTVF 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est8	NP_524259.2	COesterase	29..564	CDD:278561	165/554 (30%)
alpha-Est8	NP_524259.2	Aes	<116..>221	CDD:223730	49/114 (43%)
cel.1	NP_955901.2	COesterase	25..517	CDD:306613	162/533 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575556
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.740