Protein Alignment alpha-Est8 and CES4A

DIOPT Version :9

• Sequence 1: NP_524259.2
• Gene: alpha-Est8 / 40899
• FlyBaseID: FBgn0015576
• Length: 574
• Species: Drosophila melanogaster
• Sequence 2: XP_011521323.1
• Gene: CES4A / 283848
• HGNCID: 26741
• Length: 628
• Species: Homo sapiens
• Alignment Length: 623
• Identity: 165/623 - (26%)
• Similarity: 260/623 - (41%)
• Gaps: 144/623 - (23%)

  Fly    37 TVYGKVKGVKWQSIYGNNYYSFEGIPFAKPPVGELRFKAPVEPEHWSDVK--------------- 86
            |.||.::| |...:.......|.|:||::||:|.|||..|..||.|..::
Human    54 TKYGTLQG-KQMHVGKTPIQVFLGVPFSRPPLGILRFAPPEPPEPWKGIRDATTYPPGWSLALSP 117

  Fly    87 --------RCTHVRAKPCQVNIV-----------------------------LKQVQGSEDCLYL 114
                    |.|...|...|.:::                             .|.::.|||||||
Human   118 GWSAVARSRLTATSASRVQASLLPQPLSIWGYRCLQESWGQLASMYVSTRERYKWLRFSEDCLYL 182

  Fly   115 NVYTRELHPHRP-LPVLVWIYGGGFQMGEASRDLYSPDYIMMEHVVLVVISYRLGALGFLSL--A 176
            |||.....|..| |||:||..||.|.:|.|| .....|....|.||||.:.:|||..|||..  .
Human   183 NVYAPARAPGDPQLPVMVWFPGGAFIVGAAS-SYEGSDLAAREKVVLVFLQHRLGIFGFLRWRGR 246

  Fly   177 DEELDVPGNAGLKDQVMALRWVKRNCQFFGGDPDNITVFGESAGGASTHYMMLTDQAKGLFHKTI 241
            .::....||.||.||:.|||||:.|...|||||.|:|:||:|||..|...:|::..|.||||:.|
Human   247 TDDSHARGNWGLLDQMAALRWVQENIAAFGGDPGNVTLFGQSAGAMSISGLMMSPLASGLFHRAI 311

  Fly   242 IMSGSALAPWAQTPTHINWPYRLAQATGYTGDANDRDIFAH-LKKCKASSMLKVAEDIITMEERH 305
            ..||:||.....|...:....::|...|.  :.|...|..: |:....:.:::|:..:..::...
Human   312 SQSGTALFRLFITSNPLKVAKKVAHLAGC--NHNSTQILVNCLRALSGTKVMRVSNKMRFLQLNF 374

  Fly   306 QR---LTMFSFGPTIEPYLTPHCVIPKSPLEMMRDCWGNSIPMVIGGNSFEGLLMFPEVNKWPEL 367
            ||   ..::|..|.::     ..|||..||.::.....:|:|.::|.|:.|...:.|.:.|:|
Human   375 QRDPEEIIWSMSPVVD-----GVVIPDDPLVLLTQGKVSSVPYLLGVNNLEFNWLLPYIMKFP-- 432

  Fly   368 LCQLGDCENLAPQDAHVDEQQRKAFGKK-VRELYFGDRTPGRKT-------ILEYSDLFSYKYFW 424
                               ..|:|..|: :.::.:..||....|       :.||.|..: ::.|
Human   433 -------------------LNRQAMRKETITKMLWSTRTLLNITKEQVPLVVEEYLDNVN-EHDW 477

  Fly   425 H--------------GIHRTLLSRAHHAPLA-PTFLYRFDFDSKHFNIMRIITCGRKVRGTCHAD 474
            .              .::.||.:..:|.... |.:||.|:..:      |.|....:..|..|.|
Human   478 KMLRNRMMDIVQDATFVYATLQTAHYHRDAGLPVYLYEFEHHA------RGIIVKPRTDGADHGD 536

  Fly   475 DLSYLFYNAAAKKL---KRRTAEFKTIKRLVSMVVHFAISGDP---NIPMVCQDEKEQPRGAWLP 533
            ::.:||....|..|   |.:....:.:|    ...:||.:|:|   |:|            .|..
Human   537 EMYFLFGGPFATGLSMGKEKALSLQMMK----YWANFARTGNPNDGNLP------------CWPR 585

  Fly   534 ISKDDKVFQCLNISHDVHVIDLPEAEKLRLWDCIYDRE 571
            .:||:|..| |:.:..|. :.|.| :|:..|..:|..:
Human   586 YNKDEKYLQ-LDFTTRVG-MKLKE-KKMAFWMSLYQSQ 620

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est8	NP_524259.2	COesterase	29..564	CDD:278561	163/614 (27%)
		Aes	<116..>221	CDD:223730	50/107 (47%)
CES4A	XP_011521323.1	COesterase	46..613	CDD:278561	163/614 (27%)
		Aes	<184..>291	CDD:223730	50/107 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142747
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	216	1.000	Inparanoid score	I3612
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.790