DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est8 and SPCC417.12

DIOPT Version :9

Sequence 1:	NP_524259.2	Gene:	alpha-Est8 / 40899	FlyBaseID:	FBgn0015576	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_588289.2	Gene:	SPCC417.12 / 2539430	PomBaseID:	SPCC417.12	Length:	539	Species:	Schizosaccharomyces pombe

Alignment Length:	571	Identity:	135/571 - (23%)
Similarity:	216/571 - (37%)	Gaps:	146/571 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 YSFEGIPFAKPPVGELRFKAPVEPE----HWSDVKRCTHVRAKPCQVNIVLKQVQG-----SEDC 111
            :.|.||.:||||||:||::.||..|    :..|..:...:..:|. .|....||:.     .|||
pombe    38 HRFTGIRYAKPPVGKLRWRRPVTLEDGYDYSGDYNQFKTICPQPF-YNNRKNQVRNPDFKYDEDC 101

  Fly   112 LYLNVYT-RELHPHRPLPVLVWIYGGGFQMGEA-------SRDLY---SPDYIMMEHVVLVVISY 165
            |:||::. ....|....|||.:|:||..|:|..       .:||.   ||     ...:||...:
pombe   102 LFLNIWVPAGEKPAEGWPVLYFIHGGWLQVGNPLHYRQCDPQDLQADGSP-----AKFILVSPGH 161

  Fly   166 RLGALGFLSLAD--EELDVPGNAGLKDQVMALRWVKRNCQFFGGDPDNITVFGESAGGASTHYMM 228
            ||...|||:..:  ||.....|.|..||.:.|.|..::.:.|||:.:||.|.|.|||..|..:.:
pombe   162 RLNLFGFLAGKELLEEDPKSSNFGFWDQRLGLEWTYKHIESFGGNKENIAVGGISAGSYSALFQL 226

  Fly   229 LTD----QAKGLFHKTIIMS-GSALAPWAQTPTHINWPYRLAQATGYTGDANDRDIFAHLKKCKA 288
            :.:    :|..:..:.:::| |.::.|.:...:.|.: ..|||..|...:.:..:   .|:|.:|
pombe   227 IYETYHPEANQIIKRALLLSNGLSVQPKSVEESQIQF-NELAQKFGIPLELSSAE---KLEKLRA 287

  Fly   289 SSMLKVAEDIITMEERHQRLTMF---SFGPTIEPYLTPHCVIPKSPLEMMRDCWGNSIPMVIGGN 350
            .....:|::|:.:     ||..|   :.|..:.|             ...:|.:..:....|..:
pombe   288 IPFQDLADNILNL-----RLHTFRAVTDGDFVNP-------------NTFKDIYDGTFGKRIRDS 334

  Fly   351 SFEGLLMFPEVNKWPELLCQLGDCENLAPQDAHVD--EQQRKAFGKKVR----ELYFGDRTPGRK 409
            ..|  |:..|||....:..      |..|..:..|  .|....:.:||.    |||  .:.|..:
pombe   335 GRE--LIIGEVNNEHSIYA------NTNPPKSKEDLFNQVNNYYPEKVTKALLELY--PKVPDME 389

  Fly   410 TILEY------------SDLFSYKYFWHGIHRTLLSR--AHHAPLAPTFLYRFDFDSKHFNIMR- 459
            ...||            ||:..|     ...|.|::.  ....||...:.||..|..|.|:...
pombe   390 DEKEYLAAIKALFGSIVSDMQVY-----ASTRVLINGLVKGGVPLEKIYRYRIAFRGKFFDKYEP 449

  Fly   460 ---IITCGRKVRGTCHADDLSYLFYNAAAKKLKRRTAEFKT-IKRLVSMVVHFAISGDPNIPMVC 520
               ::.         ||.||...|||.....|......:|. :|..
pombe   450 PESLVP---------HAGDLGLWFYNVVDGILPEEIPIYKAWLKSY------------------- 486

  Fly   521 QDEKEQPRGAWLPISKDD------KVFQCLNISHDVHVIDLPEAEKLRLWD 565
                    |.|:...|.|      :.::.|:....:.|:|   .||   ||
pombe   487 --------GEWMSTGKTDWGTTKTEEYRLLDADGTIKVVD---DEK---WD 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est8	NP_524259.2	COesterase	29..564	CDD:278561	133/568 (23%)
alpha-Est8	NP_524259.2	Aes	<116..>221	CDD:223730	37/117 (32%)
SPCC417.12	NP_588289.2	PnbA	20..534	CDD:225181	135/571 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43142
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.050