DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est8 and Ces2a

DIOPT Version :9

Sequence 1:	NP_524259.2	Gene:	alpha-Est8 / 40899	FlyBaseID:	FBgn0015576	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_653344.1	Gene:	Ces2a / 246252	RGDID:	708353	Length:	558	Species:	Rattus norvegicus

Alignment Length:	607	Identity:	175/607 - (28%)
Similarity:	263/607 - (43%)	Gaps:	158/607 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 QRLRSNDKV--IADTVYGKVKG----VKWQSIYGNNYYSFEGIPFAKPPVGELRFKAPVEPEHWS 83
            |.:...|..  |.:|..|:|:|    ||...   :..::|.||||||||||.|||..|.:||.||
  Rat    22 QHVHGQDSASPIRNTHTGQVRGSFVHVKDTK---SGIHTFLGIPFAKPPVGPLRFAPPEDPEPWS 83

  Fly    84 DVKRCTHVRAKPCQVNIV----LKQVQ-------GSEDCLYLNVYT----RELHPHRPLPVLVWI 133
            .|:..|...|...|.:|:    :|:::       .||||||||:||    ||   ...|||:|||
  Rat    84 GVRDATSQPAMCLQTDIMNLDGIKEMKLTVHPTPMSEDCLYLNIYTPAHARE---GSNLPVMVWI 145

  Fly   134 YGGGFQMGEASRDLYSPDYIMMEHVVLVVISYRLGALGFLSLADEELDVPGNAGLKDQVMALRWV 198
            :|||..:|.||.:..| .....|.:|:|.|.||||.|||.|..|:  :..||.|..|||.|||||
  Rat   146 HGGGLVLGSASMNDAS-TLAATEEIVIVSIQYRLGVLGFFSTGDQ--NARGNWGYLDQVAALRWV 207

  Fly   199 KRNCQFFGGDPDNITVFGESAGGASTHYMMLTDQAKGLFHKTIIMSGSALAPWAQTPTHINWPYR 263
            ::|..:|||:...:|:||.||||.|....:::..:|||||..|:.||.||.|
  Rat   208 QQNIAYFGGNHGKVTIFGGSAGGTSVSSHVVSPMSKGLFHGAIMQSGVALLP------------- 259

  Fly   264 LAQATGYTGDAND--RDIFAHLKKCKA--SSML------KVAEDIITMEERHQRLTMFSFGPTIE 318
                 ....|.::  ....|:|..|:|  |..|      |..::|:.:.:..:.:
  Rat   260 -----DLISDKSEVVYKTVANLSGCEAPDSEALIRCLRAKSKQEILAINQVFKMI---------- 309

  Fly   319 PYLTPHCVIPKSPLEMMRDCWGNSIPMVIGGNSFE---GLLMF---------------PEVNKWP 365
            |.:.....:||.|.|::.....:.:|.:||.|:.|   |:.:|               |.|.|..
  Rat   310 PGVVDGKFLPKHPQELLASGDFHPVPSIIGINTDECGWGIPVFLGLDHIIKKITRETLPTVLKST 374

  Fly   366 ELLCQL-GDCENLAPQDAHVDEQQRKAFGKKVRELYFGDRTPGRKTILEYSDLFSYKYFWHGIHR 429
            .....| .:|.:|                  :.|.|.|| |...:|:.|        .|.|.:..
  Rat   375 AAQMMLPPECIDL------------------IMEEYMGD-TENPETLQE--------QFRHMLGD 412

  Fly   430 TL-----LSRAH-HAPLAPTFLYRFDFDSKHFNIMRIITCGRKVRGT----CHADDLSYLFYNAA 484
            .:     |..|| ....||.:.|.|.      ::...|   ::||.:    .|.||:.::|.:..
  Rat   413 FMFVIPALQVAHFQRSQAPVYFYEFQ------HLPSFI---KQVRPSHVKADHGDDILFVFGSYL 468

  Fly   485 AKKLKRRTAEFKTIKRLVSMV-VHFAISGDPN------IPMVCQDEKEQPRGAWLPISKDDKVFQ 542
            .......|.|.:.:||.|... .:||.:|:||      .|::..||:      :|.::....|.:
  Rat   469 WGMTFDLTEEEELLKRRVMKYWANFARTGNPNGEDLPHWPVLDHDEQ------YLQLNTQPAVGR 527

  Fly   543 CLNISHDVHVIDLPEAEKLRLW 564
            .|            :|.:|:.|
  Rat   528 AL------------KARRLQFW 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est8	NP_524259.2	COesterase	29..564	CDD:278561	173/601 (29%)
alpha-Est8	NP_524259.2	Aes	<116..>221	CDD:223730	50/108 (46%)
Ces2a	NP_653344.1	COesterase	30..537	CDD:395084	172/597 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336216
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.840