Protein Alignment alpha-Est8 and Ces4a

DIOPT Version :9

• Sequence 1: NP_524259.2
• Gene: alpha-Est8 / 40899
• FlyBaseID: FBgn0015576
• Length: 574
• Species: Drosophila melanogaster
• Sequence 2: NP_666325.2
• Gene: Ces4a / 234677
• MGIID: 2384581
• Length: 563
• Species: Mus musculus
• Alignment Length: 560
• Identity: 168/560 - (30%)
• Similarity: 246/560 - (43%)
• Gaps: 116/560 - (20%)

  Fly    58 FEGIPFAKPPVGELRFKAPVEPEHWSDVKRCTHVRAKPCQ------VNIVL------KQVQGSED 110
            |.||||:|||||..||..|..|..|:.::..|.......|      :::.|      |.:..|||
Mouse    58 FLGIPFSKPPVGTRRFAPPEPPLPWNGIRDATTYPPSCLQESWGQILSMYLNTRKQYKWLHFSED 122

  Fly   111 CLYLNVYTRELHPHRP-LPVLVWIYGGGFQMGEASRDLYSPDYIMME-HVVLVVISYRLGALGFL 173
            |||||||...|.|..| |||:||..||.|..|.||  .|....:... .||||.:.||||.|||.
Mouse   123 CLYLNVYAPVLAPGAPLLPVMVWFPGGAFLAGSAS--TYEGSELAARGKVVLVFLQYRLGILGFF 185

  Fly   174 SLADEELDVPGNAGLKDQVMALRWVKRNCQFFGGDPDNITVFGESAGGASTHYMMLTDQAKGLFH 238
            |..:..  ..||.||.||:.|||||:.|.:.||||||::|:||:|||..|...:|::..|:||||
Mouse   186 STGNSH--ARGNWGLLDQIAALRWVQENIEAFGGDPDSVTLFGQSAGAMSVSGLMVSPLAQGLFH 248

  Fly   239 KTIIMSGSALAPWAQTPTHINWPYRLAQATGYTGDANDRDIFAHLKKCKASSMLKVAEDIITMEE 303
            :.|..||:|:.....||..:....::|...|.  |.|...:   :.:|..|..   ||::..:.
Mouse   249 QAISQSGTAVLKAFITPDPLTSAKKIAHLAGC--DHNSTKV---MVECLRSLS---AEEVTLVS- 304

  Fly   304 RHQRLTMFSFGPTIEP-----YLTP---HCVIPKSPLEMMRDCWGNSIPMVIGGNS--FEGLLMF 358
              :|::.|......:|     :|:|   ..|.|:.|:.::.......:|.::|.|:  ||..|.|
Mouse   305 --KRMSFFQANSHKDPKEIVWFLSPVVDGVVFPEDPVVLLTRGQVKPVPYLLGVNNAEFEWNLPF 367

  Fly   359 -------------PEVNKWPELLCQLGDCENLAPQ-----------DAHVDEQQRKAFGKKVREL 399
                         ..:||   :|.......|:..:           || :.....|.|..::.:|
Mouse   368 LMKIQLNQRMMNQTNINK---ILWSFNVLLNITKEQVPVVAREYLNDA-ISNHDWKMFRNRLIDL 428

  Fly   400 YFGDRTPGRKTILEYSDLFSYKYFWHGIHRTLLSRAHHAPLAPTFLYRFDFDSKHFNIMRIITCG 464
             .||.|      ..|:.|.:.:|             |....:|.:||.|    ||.....||.
Mouse   429 -IGDAT------FVYATLQAARY-------------HRDAGSPVYLYEF----KHHASSGIII-- 467

  Fly   465 RKVRGTCHADDLSYLFYNAAAK-KLKRRTAEFKTIKRLVSMVVHFAISGDPN---IPMVCQDEKE 525
            :...|..|.|:|||||.:..:| .......||..  :::....:||.:|:||   :|.
Mouse   468 KPYNGADHGDELSYLFGSPFSKGSSAGEEKEFSL--QMMKYWANFAHTGNPNGEKLPY------- 523

  Fly   526 QPRGAWLPISKDDKVFQCLNISHDVHV-IDLPEAEKLRLW 564
                 |....||:|..|   :..|..| :.|.| :|:..|
Mouse   524 -----WPRFDKDEKYLQ---LDFDTRVGVKLKE-KKMAFW 554

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est8	NP_524259.2	COesterase	29..564	CDD:278561	167/558 (30%)
		Aes	<116..>221	CDD:223730	52/106 (49%)
Ces4a	NP_666325.2	COesterase	30..554	CDD:278561	167/558 (30%)
		Aes	<128..>272	CDD:223730	66/147 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832835
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.740