Protein Alignment alpha-Est8 and NLGN4Y

DIOPT Version :9

• Sequence 1: NP_524259.2
• Gene: alpha-Est8 / 40899
• FlyBaseID: FBgn0015576
• Length: 574
• Species: Drosophila melanogaster
• Sequence 2: NP_001352513.1
• Gene: NLGN4Y / 22829
• HGNCID: 15529
• Length: 836
• Species: Homo sapiens
• Alignment Length: 622
• Identity: 162/622 - (26%)
• Similarity: 268/622 - (43%)
• Gaps: 149/622 - (23%)

  Fly    34 IADTVYGKVKGVKW---QSIYGNNYYSFEGIPFAKPPVGELRFKAPVEPEHWSDVKRCTHVRAKP 95
            :.:|.|||::|::.   ..|.| ....:.|:|:|.||.||.||:.|..|..|:.::..|...|..
Human    47 VVNTNYGKIQGLRTPLPSEILG-PVEQYLGVPYASPPTGERRFQPPESPSSWTGIRNATQFSAVC 110

  Fly    96 CQ-------------------VNIVLKQVQG-SEDCLYLNVYT---------------------- 118
            .|                   ::.::..||. :|||||||:|.
Human   111 PQHLDERFLLHDMLPIWFTTSLDTLMTYVQDQNEDCLYLNIYVPMEDGTNIKRNADDITSNDHGE 175

  Fly   119 -RELH-PHRPLPVLVWIYGGGFQMGEASRDLYSPDYIMME--------HVVLVVISYRLGALGFL 173
             :::| .:...||:|:|:||.:..|..:         |::        :|:::.|:||||.||||
Human   176 DKDIHEQNSKKPVMVYIHGGSYMEGTGN---------MIDGSILASYGNVIVITINYRLGILGFL 231

  Fly   174 SLADEELDVPGNAGLKDQVMALRWVKRNCQFFGGDPDNITVFGESAGGASTHYMMLTDQAKGLFH 238
            |..|:.  ..||.||.||:.||||::.|...|||||..:|:||..||.:....:.|:..::|||.
Human   232 STGDQA--AKGNYGLLDQIQALRWIEENVGAFGGDPKRVTIFGSGAGASCVSLLTLSHYSEGLFQ 294

  Fly   239 KTIIMSGSALAPWAQTPTHINWPYRLAQATGYTGD---ANDRDIFAHLKKCKASSMLKVAEDIIT 300
            |.||.||:||:.||     :|  |:.|:.|....|   .|..|....::..|..:..::.:..||
Human   295 KAIIQSGTALSSWA-----VN--YQPAKYTRILADKVGCNMLDTTDMVECLKNKNYKELIQQTIT 352

  Fly   301 MEERHQRLTMFSFGPTIEPYLTPHCVIPKSPLEMMRDCWGNSIPMVIGGNSFEGLLMFPEVNKWP 365
            ....|     .:|||.|:     ..|||..|..:|......:..:::|.|..|||.....:
Human   353 PATYH-----IAFGPVID-----GDVIPDDPQILMEQGEFLNYDIMLGVNQGEGLKFVDGI---- 403

  Fly   366 ELLCQLGDCENLAPQD------AHVDE-----QQRKAFGKKVRELY--FGDR---TPGRKTILEY 414
                 :.:.:.:.|.|      ..||.     :.:....:.::.:|  :.|:   ...|||::.
Human   404 -----VDNEDGVTPNDFDFSVSNFVDNLYGYPEGKDTLRETIKFMYTDWADKENPETRRKTLVA- 462

  Fly   415 SDLFSYKYFWHGIHRTLLSRAHHAPL-APTFLYRFDFDSKHFNIMRIITCGRKVR----GTCHAD 474
              ||: .:.|  :...:.:...||.. :||:.|.|    .|.       |..:::    .:.|.|
Human   463 --LFT-DHQW--VAPAVATADLHAQYGSPTYFYAF----YHH-------CQSEMKPSWADSAHGD 511

  Fly   475 DLSYLFYNAAAKKLKRRTAEFKTIKRLVSMVV-----HFAISGDPNIPMVCQDEK---EQPRG-- 529
            ::.|:|........:..:..|.....::|.||     :||.:||||.| |.||.|   .:|..
Human   512 EVPYVFGIPMIGPTELFSCNFSKNDVMLSAVVMTYWTNFAKTGDPNQP-VPQDTKFIHTKPNRFE 575

  Fly   530 --AWLPISKDDKVFQCLNISHDVHVIDLPEAEKLRLW 564
              ||...:..|:::  |:|.....|.|...|.|:..|
Human   576 EVAWSKYNPKDQLY--LHIGLKPRVRDHYRATKVAFW 610

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est8	NP_524259.2	COesterase	29..564	CDD:278561	161/620 (26%)
		Aes	<116..>221	CDD:223730	42/136 (31%)
NLGN4Y	NP_001352513.1	COesterase	46..610	CDD:306613	161/620 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142820
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840