DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est8 and CES5A

DIOPT Version :9

Sequence 1:	NP_524259.2	Gene:	alpha-Est8 / 40899	FlyBaseID:	FBgn0015576	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_001177087.1	Gene:	CES5A / 221223	HGNCID:	26459	Length:	604	Species:	Homo sapiens

Alignment Length:	571	Identity:	165/571 - (28%)
Similarity:	252/571 - (44%)	Gaps:	146/571 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 MRI-ALNYVKFKTNQQRLRSNDKVIADTVYGKVKGVKWQSIYGN----NYYSFEGIPFAKPPVGE 70
            :|| .|||    |::....|.:....:|..|.::| |..::.|:    |.  |.|:|||.||:|.
Human    41 LRIDVLNY----TSKDEGPSAEGPQRNTRLGWIQG-KQVTVLGSPVPVNV--FLGVPFAAPPLGS 98

  Fly    71 LRFKAPVEPEHWSDVKRCTHVRAKPCQVNIVLKQVQG-----------------SEDCLYLNVYT 118
            |||..|.....|.:::..|   :.|   |:.|:..:.                 ||||||||:|.
Human    99 LRFTNPQPASPWDNLREAT---SYP---NLCLQNSEWLLLDQHMLKVHYPKFGVSEDCLYLNIYA 157

  Fly   119 -RELHPHRPLPVLVWIYGGGFQMGEASRDLYSPDYI-MMEHVVLVVISYRLGALGFLSLADEELD 181
             ........||||||..||.|:.|.||  ::....: ..|.|::||:.||||..||.:..|:.
Human   158 PAHADTGSKLPVLVWFPGGAFKTGSAS--IFDGSALAAYEDVLVVVVQYRLGIFGFFTTWDQH-- 218

  Fly   182 VPGNAGLKDQVMALRWVKRNCQFFGGDPDNITVFGESAGGASTHYMMLTDQAKGLFHKTIIMSGS 246
            .|||...||||.||.||::|.:||||||.::|:||||||..|...::|:..|||||||.|:.||.
Human   219 APGNWAFKDQVAALSWVQKNIEFFGGDPSSVTIFGESAGAISVSSLILSPMAKGLFHKAIMESGV 283

  Fly   247 ALAPWAQTPTHINWPYRLAQATGYTGDANDRDIFAH-----------LKKCKASSMLKVAEDIIT 300
            |:.|:             .:|..|. .:.|..:.||           |.:|..:   |.:::::|
Human   284 AIIPY-------------LEAHDYE-KSEDLQVVAHFCGNNASDSEALLRCLRT---KPSKELLT 331

  Fly   301 MEERHQRLTMFSFGPTIEPYLTPHCVIPKSPLEMMRDCWGNSIPMVIGGNSFEGLLMFPEVNKWP 365
            :.::.:..|....|          ...|..||:::......:||.:||.|:.|...:.| :.:.|
Human   332 LSQKTKSFTRVVDG----------AFFPNEPLDLLSQKAFKAIPSIIGVNNHECGFLLP-MKEAP 385

  Fly   366 ELLCQLGDCENLA-----------PQDAHVDEQQRKAFGKKVRELYFGDR---TPGRKTILEYSD 416
            |:|.  |..::||           ||..|:           |...||.|:   |..|.::|   |
Human   386 EILS--GSNKSLALHLIQNILHIPPQYLHL-----------VANEYFHDKHSLTEIRDSLL---D 434

  Fly   417 LFSYKYFWHGIHRTLLSRAHHAPLAPTFLYRFDFDSKHFNIMRIITCGRKVRGTC---------- 471
            |....:|  .:...:.:|.|....||.:.|.|    :|             |..|
Human   435 LLGDVFF--VVPALITARYHRDAGAPVYFYEF----RH-------------RPQCFEDTKPAFVK 480

  Fly   472 --HADDLSYLFYNAAAK----KLKRRTAEFKTIKR-LVSMVVHFAISGDPN 515
              |||::.::|..|..|    ..:..|.|.|.:.| ::.....||.:|:||
Human   481 ADHADEVRFVFGGAFLKGDIVMFEGATEEEKLLSRKMMKYWATFARTGNPN 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est8	NP_524259.2	COesterase	29..564	CDD:278561	159/552 (29%)
alpha-Est8	NP_524259.2	Aes	<116..>221	CDD:223730	48/106 (45%)
CES5A	NP_001177087.1	COesterase	56..568	CDD:278561	159/552 (29%)
CES5A	NP_001177087.1	Aes	<155..>258	CDD:223730	48/106 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142599
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	216	1.000	Inparanoid score	I3612
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.790