DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est8 and Tg

DIOPT Version :9

Sequence 1:	NP_524259.2	Gene:	alpha-Est8 / 40899	FlyBaseID:	FBgn0015576	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	XP_006520808.2	Gene:	Tg / 21819	MGIID:	98733	Length:	2767	Species:	Mus musculus

Alignment Length:	620	Identity:	153/620 - (24%)
Similarity:	239/620 - (38%)	Gaps:	187/620 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 RLRSNDKVIADTVYGKVKGVKWQSIYGNNYYSFEGIPFAKPPVGELRFKAPVEPEHWSDVKRCTH 90
            :|:...:||      || |..|:.:     |.|.|:|:|.||:.:.||:|| |..:|:.....|.
Mouse  2207 QLQGGSQVI------KV-GTAWKQV-----YRFLGVPYAAPPLADNRFRAP-EVLNWTGSWDATK 2258

  Fly    91 VRAK----------PCQVNIVLKQVQGSEDCLYLNVYTRELHPHRPLPVLVWIY------GGGFQ 139
            .||.          |.|:|         ||||||||:..| :......|||:.:      |.|.|
Mouse  2259 PRASCWQPGTRTPTPPQIN---------EDCLYLNVFVPE-NLVSNASVLVFFHNTMEMEGSGGQ 2313

  Fly   140 MGEASRDLYSPDYIMMEHVVLVVISYRLGALGFLSLADEELDVPGNAGLKDQVMALRWVKRNCQF 204
            :......|.:     :.:.::|..:||||..||||...:|  |.||.||.|||.||.||:.:...
Mouse  2314 LTIDGSILAA-----VGNFIVVTANYRLGVFGFLSSGSDE--VAGNWGLLDQVAALTWVQSHIGA 2371

  Fly   205 FGGDPDNITVFGESAGG--ASTHYMMLTDQAKGLFHKTIIMSGSALAPWAQTPTHINWPYRLAQA 267
            |||||..:|:..:.:|.  ||.|.::.......||.|.::|.||||:|.|     |..|.|..|.
Mouse  2372 FGGDPQRVTLAADRSGADVASIHLLISRPTRLQLFRKALLMGGSALSPAA-----IISPERAQQQ 2431

  Fly   268 TGYTGDANDRDIFAHLKK---CKASSMLKVA-----EDIITMEERHQRLTMFS-----FGPTIE- 318
            .            |.|.|   |..||:.:|.     :....:.:...:|...|     :||.::
Mouse  2432 A------------AALAKEVGCPTSSIQEVVSCLRQKPANILNDAQTKLLAVSGPFHYWGPVVDG 2484

  Fly   319 PYLTPHCVIP----KSPLEMMRDCWGNSIPMVIGGNSFEGLLMFPEVNKWPELLCQLGDCENLAP 379
            .||..   :|    |.||.:       .:.::|||:..:||:                   |.|.
Mouse  2485 QYLRE---LPSRRLKRPLPV-------KVDLLIGGSQDDGLI-------------------NRAK 2520

  Fly   380 QDAHVDEQQ-----RKAFGKKVRELYFGDRTPGRKTILEYSDLFSYKYFWHGIHRTLLSRAHHAP 439
            .....:|.|     :.||.:.::....|:.:..|  ||..:       .|:      .|..|...
Mouse  2521 AVKQFEESQGRTNSKTAFYQALQNSLGGEDSDAR--ILAAA-------VWY------YSLEHSTD 2570

  Fly   440 LAPTFLYRFDFDSKHFNIMRIITC---------GRKVRGTC----------HAD-----DLSYL- 479
            ...:|....:..::.:    .|.|         .|:.||..          |..     |:.|.
Mouse  2571 DYASFSRALENATRDY----FIICPMVNMASLWARRTRGNVFMYHVPESYGHGSLELLADVQYAF 2631

  Fly   480 ---FYNAAAKKLKRRTAEFKTIKRLVSMVV-----HFAISGDPNIPMVCQDEKEQPRGAW---LP 533
               ||:|       ...:|.|.::.:|:.|     :|..||:||.|.....:..:....|   :|
Mouse  2632 GLPFYSA-------YQGQFSTEEQSLSLKVMQYFSNFIRSGNPNYPHEFSRKAAEFATPWPDFIP 2689

  Fly   534 ISKDDKVFQCLNISHDVHVIDLPEAEKLRLWDCIY 568
            .:..:        |:......||..:.|:..||.:
Mouse  2690 GAGGE--------SYKELSAQLPNRQGLKQADCSF 2716

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est8	NP_524259.2	COesterase	29..564	CDD:278561	150/611 (25%)
alpha-Est8	NP_524259.2	Aes	<116..>221	CDD:223730	37/110 (34%)
Tg	XP_006520808.2	TY	34..93	CDD:238114
		TY	96..161	CDD:238114
		TY	301..359	CDD:238114
		TY	<612..658	CDD:238114
		TY	661..726	CDD:238114
		TY	730..>776	CDD:381826
		TY	<893..922	CDD:381826
		TY	1005..1074	CDD:238114
		TY	1150..1211	CDD:238114
		Ephrin_rec_like	1464..1509	CDD:311571
		TY	1519..1566	CDD:214561
		COesterase	2198..2717	CDD:365897	153/620 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832904
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930