Protein Alignment alpha-Est8 and cest-28

DIOPT Version :9

• Sequence 1: NP_524259.2
• Gene: alpha-Est8 / 40899
• FlyBaseID: FBgn0015576
• Length: 574
• Species: Drosophila melanogaster
• Sequence 2: NP_504691.2
• Gene: cest-28 / 187305
• WormBaseID: WBGene00019654
• Length: 548
• Species: Caenorhabditis elegans
• Alignment Length: 580
• Identity: 153/580 - (26%)
• Similarity: 242/580 - (41%)
• Gaps: 114/580 - (19%)

  Fly    50 IYGNNYY-------SFEGIPFAKPPVGELRFKAPVEPEHWSDVKRCTHVRAKPCQ-------VNI 100
            |.||.|.       .:.|||||||.|   |||.|.....|.:|:.||....:..|       :|.
 Worm    24 IQGNVYRIGDKTVDGYLGIPFAKPLV---RFKKPEPAGTWEEVRDCTKYGPRCPQSGPFAEAINF 85

  Fly   101 VLKQVQGSEDCLYLNVYTR---ELHPHRPLPVLVWIYGGGFQMGEASRDLYSPDY-----IMMEH 157
            ....:....:||.|||:::   ..:.::..||:|:|:|||::. .||||..  ||     :.::.
 Worm    86 QKDDIPDEANCLTLNVFSKISDSKNFNKTRPVMVYIHGGGYEC-SASRDYC--DYSVAGTLPLKD 147

  Fly   158 VVLVVISYRLGALGFLSLADEELDVPGNAGLKDQVMALRWVKRNCQFFGGDPDNITVFGESAGGA 222
            ||:|.::||:|.|||.:..|..  .|||..|.|..:.|.|::::.:.|||||.|||:||:|||.|
 Worm   148 VVVVTLNYRVGILGFFTTGDTV--CPGNFALWDLTLGLNWIQKHIESFGGDPGNITIFGQSAGAA 210

  Fly   223 STHYMMLTDQAKGLFHKTIIMSGSALAPWA--QTPTHINWPYRLAQATGYTGDANDRDIFAHLKK 285
            ....:.|:..::.||::.|:|||.||..:|  ...:.....|..|:..||.| .|.:.:|..:|.
 Worm   211 CVDLLALSPHSRDLFNRVIVMSGGALCEYAVRTANSQAKVCYEFARHLGYDG-TNSQTLFNWMKS 274

  Fly   286 CKASSMLKVAEDIITMEERHQRLTMFSFGPTIEPYLTPHC---VIPKSPLEMMRDCWGNSIPMVI 347
                   |..|:|       :::..|....:.....||:.   ..|||..|:........|.|
 Worm   275 -------KPLEEI-------EKMNGFQVPASGILAWTPNLDDDFFPKSLDELRIGAPKKDIMM-- 323

  Fly   348 GGNSFEGLLMFPEVNKWPELLCQLGDCENLAPQDA---HVDEQQRKAFG-------KKVRELYFG 402
            |....|||..        |.|.:    :...|.:|   :|:|..:|..|       .|:.|.|..
 Worm   324 GFAEHEGLFF--------EFLIK----DPTPPLEALKLYVNEYYKKDTGDHFEATRNKIIEFYSR 376

  Fly   403 --DRTPGRKTILEYSDLFSYKYFWHGIHRTLLSRAHHAPLAPTFLYRFDF-------DSKHFNIM 458
              :.|..:.|.....|......|..|:.....:...|.  ...:||.||:       :.:.|  |
 Worm   377 NVEDTDEKSTKERLIDFVGDALFTAGVFDNAKNCLKHG--NNVWLYIFDYCNPSGFGNQEEF--M 437

  Fly   459 RIITCGRKVRGTCHADDLSYLFYNAAAKKLKRRTAEFKTIKRLVSMVVHFAISGDPNIPMVCQDE 523
            ..:       ...|..||.|:.........:....|.|.|:::.::..:||..|:||
 Worm   438 TFV-------APTHCTDLRYVLGEGLYSDFQPTEEEHKMIEKMTTIYSNFAKYGNPN-------- 487

  Fly   524 KEQPRGAWLPISKDD--KVFQCL----NISHDVH-----VIDLPEAEKLRLWDCIYDREL 572
             |.....|...:.|:  :.||..    .:.:|.|     .::|..|:...|.:.:|.|.|
 Worm   488 -EHGSSEWEKFTLDNPRRHFQISYPRGKMRNDYHPDRMKFLELIRAKNQNLENVVYGRGL 546

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est8	NP_524259.2	COesterase	29..564	CDD:278561	149/570 (26%)
		Aes	<116..>221	CDD:223730	43/112 (38%)
cest-28	NP_504691.2	COesterase	17..516	CDD:278561	145/548 (26%)
		Aes	<112..>222	CDD:223730	45/114 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm14771
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.810