DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est8 and cest-3

DIOPT Version :9

Sequence 1:	NP_524259.2	Gene:	alpha-Est8 / 40899	FlyBaseID:	FBgn0015576	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_510042.2	Gene:	cest-3 / 181385	WormBaseID:	WBGene00008451	Length:	588	Species:	Caenorhabditis elegans

Alignment Length:	581	Identity:	147/581 - (25%)
Similarity:	234/581 - (40%)	Gaps:	134/581 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LNYVKFKTNQQRLRSNDKVIADTVYGKVKGVKWQSIYGNNYYSFEGIPFAKPPVGELRFKAPVEP 79
            |.|:.|...   |..:.:.|..|.|||::| |..::   :.:.|:.:||||||:|:|||..|...
Worm     7 LYYILFVFT---LNGSGQRIISTTYGKLEG-KTVNV---DQHMFKNVPFAKPPLGKLRFSLPEWT 64

  Fly    80 EHWSDVKRCTHVRAKPCQVNIVLKQVQG----SEDCLYLNVYTRE-LHPHRPLPVLVWIYGGGFQ 139
            ..|.:::..|.. :..|..|..::....    |||||||||:|.| ....:....:|:.:|||..
Worm    65 NPWKNIRNATEY-SPSCFSNSSMRTDSNFFPMSEDCLYLNVFTNEYCLKSKNCSTVVYYHGGGIN 128

  Fly   140 MGEASR--DLYSPDYIMMEHVVLVVISYRLGALGFLSLADEELDVPGNAGLKDQVMALRWVKRNC 202
            |..|.:  |.:..:..:.|:||.::.:||||..|.|......| ||.|..:.|..:|||::.:..
Worm   129 MDSAVQFNDTFILERYVKENVVFIIPAYRLGIFGLLYFGSNNL-VPQNLAIHDCELALRFIHQEI 192

  Fly   203 QFFGGDPDNITVFGESAG-------GASTHYMMLTDQAKGLFHKTIIMSGSALAPWAQTPTH--- 257
            ..|||..|:|.:.|.|||       |.|.|    .|....|.::.|::|        ..|::
Worm   193 SNFGGHKDDINLMGHSAGAHISLIFGFSRH----IDPDHKLINRIIVLS--------PVPSYDMP 245

  Fly   258 ---INWPYRLAQATG-YTGDANDRDIFAHLKKCKASSMLKVAEDIITMEE--RHQRLTMFSF--G 314
               |...|..|:..| |..:...||  ..:.||...   |.|..:::|:.  .:.||..::|  |
Worm   246 ELLIKNCYDFAERVGCYKRNVTARD--TEIVKCLRK---KDARGLMSMQRLMENDRLYFWNFLAG 305

  Fly   315 PTIEPYL-TPHCVIPKSPLEMMRDCWGNSIPMVIGGNSFEGLLMFPEVNKWPELLCQLGDCENLA 378
               ||:: ....:.......:.||       |:| ||:.:      || ||..|     ..||.|
Worm   306 ---EPFMYRDESIADFKEYAVKRD-------MLI-GNTVD------EV-KWKRL-----KKENPA 347

  Fly   379 PQDAHVDEQQRKAFGKKVRELYFGDRTPGRKTILEYSDLFSYKYFWHGIHRTLLSRAHHAPLAPT 443
            ...:.:|.:.......|..  ::.|..|...|         |:.|..||..:..:.|.....|..
Worm   348 IAGSFMDWENPYEVAHKFN--FYHDSAPVNST---------YESFTQGIFVSTATYAEAQANAGG 401

  Fly   444 FLYRFDFD---SKHFNIMRIITCGRKVRGT----CHADDLSYL--FYNAAAKKLKRRTAEFKTIK 499
            .:|.|..:   |.|.:.|:...      ||    .|..|:..:  ||:
Worm   402 TVYLFQSNQQPSSHVSDMQYFV------GTHREDYHTSDMDIMDTFYS----------------- 443

  Fly   500 RLVSMVVHFAISGDPN---IPMVCQD------EKEQPRGAWLPISKD----DKVFQCLNIS 547
               .|:|:|...|.|:   .|:|...      |....:|.|..:.:|    |..|..:|::
Worm   444 ---KMIVNFTKFGSPSPVWEPLVPSRMNYYALEVNTEKGIWPRMEEDFHESDVNFWFINMT 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est8	NP_524259.2	COesterase	29..564	CDD:278561	143/567 (25%)
alpha-Est8	NP_524259.2	Aes	<116..>221	CDD:223730	36/114 (32%)
cest-3	NP_510042.2	Abhydrolase	23..496	CDD:304388	141/555 (25%)
cest-3	NP_510042.2	Aes	<118..>254	CDD:223730	42/148 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157123
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740