DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est8 and cest-19

DIOPT Version :9

Sequence 1:	NP_524259.2	Gene:	alpha-Est8 / 40899	FlyBaseID:	FBgn0015576	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_509187.4	Gene:	cest-19 / 180973	WormBaseID:	WBGene00020125	Length:	607	Species:	Caenorhabditis elegans

Alignment Length:	511	Identity:	163/511 - (31%)
Similarity:	234/511 - (45%)	Gaps:	100/511 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 GNNYYSFEGIPFAKPPVGELRFKAPVEPEHWSDVKRCTHVRAKPCQVNI----------VLKQVQ 106
            |.:|..|:|||||.||||.|||:.|.||..|..|...|...|. |..||          .:..|
Worm    44 GQDYSVFKGIPFAMPPVGYLRFQMPKEPAKWRGVMNATQYSAM-CMQNIDENDAGEPERYVAHV- 106

  Fly   107 GSEDCLYLNV-------YTRELHPHRPLPVLVWIYGGGFQMGEASRDLYSPDYIMMEH-----VV 159
             |||||||||       ||.:.:     ||:|:|:||.||.|..| |:  |...::.:     :|
Worm   107 -SEDCLYLNVFSPTPYQYTNDTY-----PVIVFIHGGRFQTGSGS-DI--PQRAILSNFVSRKIV 162

  Fly   160 LVVISYRLGALGFLSLADEELDVPGNAGLKDQVMALRWVKRNCQFFGGDPDNITVFGESAGGAST 224
            .|..:||||.|||.|..|..|  |||.||.||:.||:|||.|.:.|||||.||.:.|...|.||.
Worm   163 FVTFNYRLGPLGFASTGDSVL--PGNIGLWDQIWALKWVKANAEVFGGDPSNILLMGHGTGAASA 225

  Fly   225 HYMMLTDQAKGLFHKTIIMSGSALAPWAQTPTHINWPYRLAQATGYTGDANDRDIFAHLKKCKA- 288
            ..:.|:.:|:|||.|.::||||||.|.....|.:|          .|.:.|||  |.    |:|
Worm   226 SLLALSPRAEGLFQKVLLMSGSALQPGVVRNTQVN----------ATWNMNDR--FG----CRAF 274

  Fly   289 --SSMLKVA-----EDIITMEERHQRLTMF----SFGPTIEPYLTPHCVIPKSP--LEMMRDCWG 340
              |.:|..|     |:|...:..|     |    .|.|.|:..   ..::|:.|  |.:.|
Worm   275 NSSELLDCARKRSKEEIFQYKRLH-----FDDYEEFVPIIDGV---GGILPEPPEQLTLHR---- 327

  Fly   341 NSIPMVIGGNSFEGLLMFPEVNK----WPELLCQLGD--CENLAPQDAHVDEQQRKAFGKKVREL 399
            ...|:|||....|..|....:|:    :..:..:.|:  .:||..........:..:.|.|...:
Worm   328 RKTPIVIGTTKDESSLRILLLNEKDLNFSSITWENGETLADNLTLGFKQFQNHRLISQGCKSEYV 392

  Fly   400 YFGDRTPGRKTILEYSDLFSYKYFWHGIHRTLLSRAHHAPLAPTFLYRFDFDSKHF-NIMRIITC 463
            :........:::|..|.|..|.:||:....:.|:..:.....|.:||.||..|::| :|.|..
Worm   393 WTQVDPSFPESVLFNSLLKMYSHFWYDAPASQLATYYLKHDLPVYLYSFDHISENFYDIDRAF-- 455

  Fly   464 GRKVRGTCHADDLSYLFYNAAAKKL-KRRTAEFKTIKRLV----SMVVHFAISGDP 514
                    |..|..::| |...:.| ||:...::..:|:|    .:|.:||:.|.|
Worm   456 --------HGVDKLHIF-NVTPRFLNKRKDMNWQLDQRVVEIFSELVANFALYGTP 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est8	NP_524259.2	COesterase	29..564	CDD:278561	163/511 (32%)
alpha-Est8	NP_524259.2	Aes	<116..>221	CDD:223730	48/116 (41%)
cest-19	NP_509187.4	Abhydrolase	27..544	CDD:389770	163/511 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.810