Protein Alignment alpha-Est8 and cest-2.2

DIOPT Version :10

• Sequence 1: NP_524259.2
• Gene: alpha-Est8 / 40899
• FlyBaseID: FBgn0015576
• Length: 574
• Species: Drosophila melanogaster
• Sequence 2: NP_001256567.1
• Gene: cest-2.2 / 179917
• WormBaseID: WBGene00013874
• Length: 672
• Species: Caenorhabditis elegans
• Alignment Length: 540
• Identity: 134/540 - (24%)
• Similarity: 219/540 - (40%)
• Gaps: 97/540 - (17%)

  Fly    25 QRLRSNDKVIAD---TVYGKVKGVKWQSIYGNNYYSFEGIPFAKPPVGELRFKAPVEPEHWSDVK 86
            |.:||....::.   |:.|:.....:..:.......|.|:|:.:||||.|||:.|..|:.|..|.
 Worm    13 QNVRSTKVKLSSRTGTIEGRTLTASYSPLGNQTGIVFFGVPYVEPPVGNLRFRKPRPPKPWDGVL 77

  Fly    87 RCTHVRAKPC---QVNIVLKQVQG--SEDCLYLNVYTRE-LHPHRPLPVLVWIYGGGFQMGEASR 145
            .....:| .|   |.......|.|  ||||||.||:|.: ...|:...|::.|:||.|.:..||
 Worm    78 EAKEYKA-ACMSDQKKTYKNGVGGPVSEDCLYANVFTNQYCLEHKNCSVMLTIHGGRFVIESAS- 140

  Fly   146 DLYSPDYIMM------EHVVLVVISYRLGALGFLSLADEELDVPGNAGLKDQVMALRWVKRNCQF 204
             .|.|:.|:.      .::|:|..:||||..|...|..:..|.  |.||.|.:..:||.::..:.
 Worm   141 -AYDPEIIINNFVGQGRNIVVVTFNYRLGLFGLGMLNGDNQDT--NFGLYDILEVVRWTRKEIKN 202

  Fly   205 FGGDPDNITVFGESAGGASTHYMMLTDQAKGLFHKTIIMSGSALAPWAQTPTHINWPYRLAQATG 269
            ||||.|.||:.|.|||...|.....:..:|||.|:.||||.|...  ....:::.....:|:..|
 Worm   203 FGGDKDRITMQGHSAGAVFTAAFSTSPLSKGLIHQQIIMSASMSN--LSKKSNVKELTVVARIVG 265

  Fly   270 YTGDANDRDIFAHLKKCKASSML--KVAEDIITMEERHQRLTMFSFGP----------------- 315
            ...|.:.....::::..||.:.|  |.|:.|:..:....|.|.:..|.
 Worm   266 CLPDEHGFPKLSNVEVEKAYTCLRSKSAQQILDAQLYMLRNTTYYIGQGHIDGIYQVDYPDNLYA 330

  Fly   316 --TIEPYLTPHCVIPKSPLEMMRDCWGNSIPMVIGGNSFEGLLMFPEVNKWPELLCQLGDCENLA 378
              :|.|..|   :|..:..|:|...:                ::.|:.....|:|.|     ||.
 Worm   331 TNSIYPINT---MIGTTTAELMDSRY----------------IVDPKNTGKKEILLQ-----NLC 371

  Fly   379 PQDAHVDEQQRKAFGKKVRELYFGDRTPGRKTILEYSDLFSYKYFWHGIHRTLLSRAHHAPLAPT 443
            ....:...::.:.|.:|.|..|        |...:...|.....|::|..:  |:..|.:.....
 Worm   372 EHIGYELYKEPEEFSQKCRNFY--------KNGEDAKSLGDDMEFYYGAIQ--LANVHSSKDTNV 426

  Fly   444 FLYRFDFDS-----KHFNIMRIITCGRKVRGTCHADDLSYLFYNAAAKKLKRRTAEFKTIKRLVS 503
            |:|.||:..     |.::         |.....|.:|.:|.|   ...:....|.:: .|:.:.|
 Worm   427 FVYSFDYKEAGNAYKKYD---------KSLSPKHGEDFAYAF---GTNRGNFSTKDY-VIEYIYS 478

  Fly   504 -MVVHFAISGDPNIPMVCQD 522
             |...|...|||: |:..|:
 Worm   479 GMFADFVNFGDPS-PLEDQE 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est8	NP_524259.2	COesterase	34..564	CDD:395084	131/531 (25%)
cest-2.2	NP_001256567.1	alpha/beta hydrolases	25..534	CDD:473884	131/528 (25%)