DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est8 and cest-33

DIOPT Version :9

Sequence 1:	NP_524259.2	Gene:	alpha-Est8 / 40899	FlyBaseID:	FBgn0015576	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_504621.1	Gene:	cest-33 / 179020	WormBaseID:	WBGene00017431	Length:	554	Species:	Caenorhabditis elegans

Alignment Length:	544	Identity:	153/544 - (28%)
Similarity:	249/544 - (45%)	Gaps:	102/544 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LNYVKFKTNQQRLRSNDKVIADTVYGKVKGVKWQSIYGNNYYSFEGIPFAKPPVGELRFKAPVEP 79
            |:::..:.|.:.|:::...:...:|      |...:..:.|.   |||:|||||||||||.||..
Worm     5 LSHLTPEQNVEALKASCGPVRGNIY------KHDDVIVDGYL---GIPYAKPPVGELRFKKPVTV 60

  Fly    80 EHWSDVKRCTHVRAKPCQVNIVLKQVQG-------SEDCLYLNVYT-----RELHPHRPLPVLVW 132
            :.|:::|.| :.....|......:|:.|       ...||.|||:|     .|....|  ||:|:
Worm    61 DVWTEIKDC-YKYGPACVQTGGFEQIAGPRTPTPEEAGCLTLNVFTPRNASSEFKNGR--PVMVY 122

  Fly   133 IYGGGFQMGEASRDL--YS-PDYIMMEHVVLVVISYRLGALGFLSLADEELDVPGNAGLKDQVMA 194
            |:|||:::. ||.|.  || ...:.::.||:|.|:||||..|||:..|..  .|||.||.||.:|
Worm   123 IHGGGYELC-ASSDFCAYSLSGTLPLKDVVVVSINYRLGVFGFLTTGDNV--CPGNFGLWDQTLA 184

  Fly   195 LRWVKRNCQFFGGDPDNITVFGESAGGASTHYMMLTDQAKGLFHKTIIMSGSALAPWAQTPTHIN 259
            |:||:::...|||||:.:||||:|||||||..:.|:..::.||.:.|.:||:|         |.:
Worm   185 LKWVQKHISSFGGDPNCVTVFGQSAGGASTDLLSLSPHSRDLFQRFIPISGTA---------HCD 240

  Fly   260 WPYR-----------LAQATGYTGDANDRDIFAHLKKCKASSMLKVAEDIITMEERHQRLTMF-S 312
            :..|           .|:..|::|    ||..|..|..:..|    .|.:..::...:.::.| :
Worm   241 FAIRASENQAKIFREFAEFHGFSG----RDSSALFKWYQEQS----PETLSNVKGYKKSISGFLT 297

  Fly   313 FGPTIEPYLTPHCVIPKSPLEMMRDCWGNSIP---MVIGGNSFEGLL---MFPEVNKWPELLCQL 371
            |.|.::....|      .||:.:|    ...|   |:.|...:|||:   |.|..:.     ..:
Worm   298 FIPNLDGDFFP------KPLDELR----KEAPKKQMMTGVTEYEGLMLASMNPAFSP-----ADV 347

  Fly   372 GDCENLAPQD-------AHVDEQQRKAFGKKVRELYFGDRTPGRKTILEYSDLFSYKYFWHGIHR 429
            |  ..|.||.       ::.||.|:..:.|.|..:...|....||.:.|   ....::|..|:.:
Worm   348 G--LTLMPQGIYGKDVVSNPDEIQKIFYEKYVEGVDKSDELAMRKKLCE---ALGDEFFNVGVIQ 407

  Fly   430 TLLSRAHHAPLAPTFLYRFDF---DSKHFNIMRIITCGRKVRGTCHADDLSYLFYNAAAKKLKRR 491
            ...:.|.|.  ...:.|.|::   ||  |.:...:   ...:...|..:|.||.......|.:..
Worm   408 AAKNAAKHG--NEVYFYTFEYVNPDS--FGMWDGM---MPFKAAVHCTELRYLLGEGVYSKFEPT 465

  Fly   492 TAEFKTIKRLVSMVVHFAISGDPN 515
            ..:.|.::...::..:||..|:||
Worm   466 EEDRKVMETTTTLFSNFAKYGNPN 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est8	NP_524259.2	COesterase	29..564	CDD:278561	150/530 (28%)
alpha-Est8	NP_524259.2	Aes	<116..>221	CDD:223730	50/112 (45%)
cest-33	NP_504621.1	Esterase_lipase	16..521	CDD:238191	151/533 (28%)
cest-33	NP_504621.1	Aes	<103..>224	CDD:223730	56/125 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm14771
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.810