DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est8 and cest-32

DIOPT Version :9

Sequence 1:	NP_524259.2	Gene:	alpha-Est8 / 40899	FlyBaseID:	FBgn0015576	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_504397.1	Gene:	cest-32 / 178909	WormBaseID:	WBGene00016862	Length:	545	Species:	Caenorhabditis elegans

Alignment Length:	520	Identity:	143/520 - (27%)
Similarity:	227/520 - (43%)	Gaps:	96/520 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 RSNDKVIADTVYGKVKGVKWQSIYGNNYYSFEGIPFAKPPVGELRFKAPVEPEHWSDVKRCTHVR 92
            |.:||::                  |.|.   ||||||.|:.|||||.|||.|.|:....| |..
Worm    30 RHDDKIV------------------NGYL---GIPFAKAPICELRFKKPVEAEKWTKPLNC-HKY 72

  Fly    93 AKPC-QVNIVLKQV------QGSED-CLYLNVYT----RELHPHRPLPVLVWIYGGGFQMGEASR 145
            ...| |...::..:      :.:|| ||.||::.    .|..|: .||::|:.:||||::|.:|.
Worm    73 GPGCPQSGHMISNLLPPGYREFAEDNCLNLNIFAPSWKSEEFPN-GLPIMVYFHGGGFEIGFSSM 136

  Fly   146 -DLYS-PDYIMMEHVVLVVISYRLGALGFLSLADEELDVPGNAGLKDQVMALRWVKRNCQFFGGD 208
             |.|| ...:.::.|::|..:||:|.|||::..||.  ..||.||.||.:||:||:.:.:.|||:
Worm   137 FDDYSLSGTLPLKDVIVVTANYRVGPLGFMTTGDEV--SRGNYGLWDQTLALKWVQEHIKSFGGN 199

  Fly   209 PDNITVFGESAGGASTHYMMLTDQAKGLFHKTIIMSGSALAPWA-QTPTHINWPYR-LAQATGYT 271
            |:.:||.|.||||.|...:.|:..:..|||:.:.|||||...:: :|.......:| .|:..||.
Worm   200 PNIVTVCGTSAGGVSAGLLALSPHSNKLFHRFMAMSGSAFCEFSIRTKEQEAEIFRNFAKHHGYE 264

  Fly   272 GDANDRDIFAHLKKCKASSMLKVAEDIITMEERHQRLTMFSFGPTIEPYLTPHCVIPKSPLEMMR 336
            |:.::     .|.:...|..|...::..|.|::..  ...:|.|..:...     .||...|:.|
Worm   265 GEDSE-----SLLEWYKSQPLSKFQETATFEKKAS--GFLTFIPNFDGDF-----FPKPFDELSR 317

  Fly   337 DCWGNSIPMVIGGNSFEG---LLMF-PEVNKWPELLCQLGD--CENLAPQDAHVDEQQRKAFGKK 395
            :  ...:..:...:.:||   |.|| ...|....:....|.  .||.      ||.|      |:
Worm   318 E--APKLDAMATVDEYEGLGFLTMFQSRRNDMDIIKSSFGSDVVENA------VDVQ------KR 368

  Fly   396 VRELYFG--DRTPGRKTILEYSDLFSYKYFWHGIHRTLLSRAHHAPLAPTFLYRFDFDSKHFNIM 458
            :.|.|..  |:...:........|.|..:|..|...|:.:...:...|  :|..||:    :|:
Worm   369 IMEFYMKNIDKNDDKAVEKRLIQLISDSWFNIGALETVKTSTKYGSNA--YLGSFDY----YNM- 426

  Fly   459 RIITCGRK--------VRGTCHADDLSYLFYNAAAKKLKRRTAEFKTIKRLVSMVVHFAISGDPN 515
                 |..        .:...|..:|.|:. .....|......|||.|..:.::..:|...|:||
Worm   427 -----GSNDPYATWFPFKAANHGSELKYML-GEGMGKFSPIEEEFKVIDMMGTLTANFVKYGNPN 485

Fly 516 515
Worm 486 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est8	NP_524259.2	COesterase	29..564	CDD:278561	142/519 (27%)
alpha-Est8	NP_524259.2	Aes	<116..>221	CDD:223730	43/110 (39%)
cest-32	NP_504397.1	COesterase	15..516	CDD:278561	143/520 (28%)
cest-32	NP_504397.1	Aes	<104..>227	CDD:223730	47/125 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157249
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.740