DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est8 and cest-6

DIOPT Version :9

Sequence 1:	NP_524259.2	Gene:	alpha-Est8 / 40899	FlyBaseID:	FBgn0015576	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_501070.1	Gene:	cest-6 / 177459	WormBaseID:	WBGene00020688	Length:	583	Species:	Caenorhabditis elegans

Alignment Length:	492	Identity:	125/492 - (25%)
Similarity:	202/492 - (41%)	Gaps:	90/492 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 SIYGN---NYYSFEGIPFAKPPVGELRFKAPVEPEHWSDVKRCTHVRAKPCQVN-IVLKQVQG-- 107
            ||.||   :|.:|:.|||||||:|:|||:.|:..|.|..:...|.. ...|..| ...|..|.
Worm    32 SINGNQIGSYQTFKKIPFAKPPIGKLRFQKPMAAEKWEGILNATEY-GPACMSNSSTSKSPQKWI 95

  Fly   108 SEDCLYLNVYTRE-LHPHRPLPVLVWIYGGGFQMGEA--SRDLYSPDYIMMEHVVLVVISYRLGA 169
            .||||::|::|.: ....:...|:.:::||......|  ..|.|..|......|:||:.::|||.
Worm    96 DEDCLHINIFTTDTCLSSKNCSVVFYVHGGELVYDSAVMFEDKYLFDTFSSRDVILVIPAFRLGL 160

  Fly   170 LGFLSLADEELDVPGNAGLKDQVMALRWVKRNCQFFGGDPDNITVFGESAGGASTHYMMLTDQAK 234
            .....:.|:.: .|.|..|.|.::||.:||.....|||..|.:|.||.|.||.....|..:.:..
Worm   161 FSHFVVEDQNV-APNNLALYDILLALEFVKSEIHNFGGSSDRVTAFGHSYGGHVVSVMAFSTEIN 224

  Fly   235 ---GLFHKTIIMSGSALAPWAQTPTHINWPYRLAQATGYTGDANDRDIFAHLKKCKASS-MLKVA 295
               ..|.:.|.|  |::..|......|....|..|   |...:..:|:.:.:...:..| |::..
Worm   225 TDLSYFQRVICM--SSVNVWDSLEFEIEKTMRFIQ---YANCSVPQDLKSRMTSFEQDSYMMECL 284

  Fly   296 EDIITMEERHQRLTMFSFGPTIEPYLTPHCVIPKSPL---EMMRDCW--GNSIPMVIGGNSFEGL 355
            :||.:||....:.::...|..|...|     :.:.||   .:::|.:  ..:||.:.|
Worm   285 QDIDSMELLRIQRSLEDEGHPIYSGL-----VLREPLIQNVLVQDFYEKPKNIPTLTG------- 337

  Fly   356 LMFPEVNK---WPELLCQLG-----DCENLAPQDAHVDEQQRKAFGKKVRELYFGDRTPGRKTIL 412
            ..:.|::|   :..::..||     :|:     |.:.|:::...|.....    .|.|.|   ||
Worm   338 CTYKELDKFHAYHNIVETLGYENYKECD-----DKYRDDRKYGRFDLNKH----ADETFG---IL 390

  Fly   413 EYSDLFSYKYFWHGIHRTLLSRAHHAPLAPTFLYRFDFDSKHFNIMRIITCGRKVRGTCHADDLS 477
            ..:.|...|....||              ||:.|.:.: .||               ..|.||||
Worm   391 AQTKLKVDKQLDKGI--------------PTYFYEYSY-PKH---------------PSHTDDLS 425

  Fly   478 YLFYNAAAKKLKRRTAEFKTIKRLVSMVVHFAISGDP 514
            |:....|.:|.:.   |....|....|.::|...|:|
Worm   426 YIMGVHAFEKDEN---EIHLAKSYQEMFMNFVKFGEP 459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est8	NP_524259.2	COesterase	29..564	CDD:278561	125/492 (25%)
alpha-Est8	NP_524259.2	Aes	<116..>221	CDD:223730	31/107 (29%)
cest-6	NP_501070.1	Abhydrolase	25..500	CDD:389770	125/492 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156939
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740