DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est8 and cest-25

DIOPT Version :9

Sequence 1:	NP_524259.2	Gene:	alpha-Est8 / 40899	FlyBaseID:	FBgn0015576	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_497609.1	Gene:	cest-25 / 175390	WormBaseID:	WBGene00022178	Length:	550	Species:	Caenorhabditis elegans

Alignment Length:	498	Identity:	150/498 - (30%)
Similarity:	229/498 - (45%)	Gaps:	45/498 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 TVYGKVKGVKWQSIYGNNYYSFEGIPFAKPPVGELRFKAPVEPEHWSDVKRCTHVRAKPCQVNIV 101
            |.||.::|.:..........:|:|||:|.||:|.|||..|...|.|::|:......|:..|.:.|
Worm    21 TSYGPIEGRRLIHEGEKQVDAFQGIPYAAPPIGNLRFALPQPHEKWTEVRETKSFGARGIQKDHV 85

  Fly   102 L--KQVQGSEDCLYLNVYTRELHPHRP--LPVLVWIYGGGFQMGEASR--DLYSPDYIMMEHVVL 160
            |  |....|||.|.||::|....|...  .||:::|:||||....|.:  |:....:::.:.||:
Worm    86 LSPKTSPQSEDNLTLNIFTPVWTPKNETGFPVILYIHGGGFVSDSAHKYGDMSICQHLVTKDVVV 150

  Fly   161 VVISYRLGALGFLSLADEELDVPGNAGLKDQVMALRWVKRNCQFFGGDPDNITVFGESAGGASTH 225
            |.|.||||.|||.:..|.  .:|.|..|.|.|.||:|||.|...|.|||:|||:.|:||||||..
Worm   151 VTIQYRLGFLGFWTTGDS--SIPDNVALHDMVFALKWVKENIGLFNGDPNNITLMGQSAGGASVD 213

  Fly   226 YMMLTDQAKGLFHKTIIMSGSALAPWAQTPTHINWPYRLAQATGYTGDANDRDIFAHLKKCK--- 287
            ::.::..::.||.|.|.|.|:|...||..|..:|.....||..|.....|..|....|::..
Worm   214 FLSISPVSRDLFQKVIPMGGNASCSWAIHPRPLNACRNRAQEIGVFDGMNTLDWVEKLRELPADK 278

  Fly   288 -ASSMLKVAEDIITMEERHQRLTMFSFGPTIEPYLTPHCVIPKSPLEMMRDCWGNSIPMVIGGNS 351
             ||::...|.|..|..|       ...||..:     :..||:..:|:.::  ....|.::|...
Worm   279 FASALNMEAVDTKTDPE-------LLIGPKYD-----NLFIPRPVMELRKE--APMKPRLLGCAK 329

  Fly   352 FEGLLM-FPEVNKWPELLCQLGD-----CENLAPQDAHVDEQQRKAFGKKVRELYFGDRTPGRKT 410
            .|||:. |..:|....|.....|     .|.|.|..|.  :.|.||..|.:.......:...::.
Worm   330 SEGLVFAFFGLNTKHPLHAVQQDVSAILSEKLFPLKAR--DYQEKALEKLIEIGTDHSKEEWQRA 392

  Fly   411 ILEYSDLFSYKYFWHGIHRTLLSRAHHAPLAPTFLYRFDF-DSKHFNIMRIITCGRKV--RGTCH 472
            ::   ||....:...||.:.:|......|..|.::|.||: :.|.:.||     |.|:  :...|
Worm   393 MV---DLKGDSFLNVGIQQNVLDVLETQPSTPIYMYSFDYCNPKAYGIM-----GFKLPFKDATH 449

  Fly   473 ADDLSYLFYNAAAKKLKRRTAEFKTIKRLVSMVVHFAISGDPN 515
            ..|:||:..|...........::|.|:....:..:||..|:||
Worm   450 CTDISYVVGNHIVNSFDFNEEDYKMIEITTRLWTNFAKYGNPN 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est8	NP_524259.2	COesterase	29..564	CDD:278561	150/498 (30%)
alpha-Est8	NP_524259.2	Aes	<116..>221	CDD:223730	44/108 (41%)
cest-25	NP_497609.1	COesterase	18..536	CDD:365897	150/498 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222591at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm14771
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.820