Protein Alignment alpha-Est8 and cest-27

DIOPT Version :9

• Sequence 1: NP_524259.2
• Gene: alpha-Est8 / 40899
• FlyBaseID: FBgn0015576
• Length: 574
• Species: Drosophila melanogaster
• Sequence 2: NP_871861.2
• Gene: cest-27 / 171610
• WormBaseID: WBGene00018958
• Length: 561
• Species: Caenorhabditis elegans
• Alignment Length: 598
• Identity: 156/598 - (26%)
• Similarity: 252/598 - (42%)
• Gaps: 141/598 - (23%)

  Fly    34 IADTVYGKVKGVKWQSIYGNNYYSFEGIPFAKPPVGELRFKAPVEPEHWSDVKRCTHVRAKPCQV 98
            :.|...|.:|||.::...|:....|.|||:|:||:|.||||.||....|::...|.....:..|.
 Worm    27 VHDATCGPIKGVGYEQEDGSVVEGFLGIPYAEPPIGALRFKKPVAHRKWTEPLDCVRFGPRSPQN 91

  Fly    99 NIVLKQV-----QGSEDCLYLNVYTRELHPHR---PLPVLVWIYGGGFQMGEAS--------RDL 147
            :.:|.|.     :..|.||.|||:|.:...:.   ..||:|:|:||||.:..:|        |:|
 Worm    92 DELLGQFVNTVGKSEEHCLSLNVFTPKWESNEWPDGFPVMVFIHGGGFAVHSSSNYGCASIARNL 156

  Fly   148 YSPDYIMMEHVVLVVISYRLGALGFLSLADEELDVPGNAGLKDQVMALRWVKRNCQFFGGDPDNI 212
            .:.|      ||:|.|:||||.|||.:..||.  ..||.||.||..||.||:.|.|.|.|||||:
 Worm   157 CTKD------VVVVTINYRLGVLGFFTTGDEV--CRGNLGLWDQTAALEWVQENIQSFRGDPDNV 213

  Fly   213 TVFGESAGGASTHYMMLTDQAKGLFHKTIIMSGSALAPWAQ--TPTHINWPYRLAQATGYTGDAN 275
            |:||:||||||...:.|:..::|||::.|.|:|:....:|.  :..........|:..|:.||.|
 Worm   214 TIFGQSAGGASVDLLCLSPHSRGLFNRAIPMAGNGECDFAMRTSEQQAQLSREFARYLGWEGDDN 278

  Fly   276 DRDIFAHLKKCKASSMLKVAEDIITMEERHQRLTMFSFGPTIEP------------YLTPHC--- 325
            |                  :||::...:: |.|.....|  |.|            |..|:.
 Worm   279 D------------------SEDLLQFIDQ-QPLYKIEMG--INPKRGFKHSQAGSLYFVPNFDGD 322

  Fly   326 VIPKSPLEMMRDCWGNSIPMVIGGNSFEGL--LMFPEVNKWPELLCQLGDCENLAPQDAHVDEQQ 388
            ..|| ||..:|. ....:.::.|...:|||  :....::|.||.:
 Worm   323 FFPK-PLNQLRK-EAPKMQIMTGTTKYEGLFFIALGALSKNPEGI-------------------- 365

  Fly   389 RKAFGKKVRELYFGDRTPGRKTILEYSDLFSYKYFWHGIH------------------------- 428
            :|..|:..:|..:|:|.   ..:|:    ..|.:::.|:|
 Worm   366 KKFMGRIFKECDYGERA---DDVLQ----MVYDFYFKGVHPKDHEKNMHQIVKFIGDYSINYGTY 423

  Fly   429 --RTLLSRAHHAPLAPTFLYRFDF-DSKHFNIMRIITCGRKVRGTCHADDLSYLFYNAAAKKLKR 490
              ..:::...|    ..:.|:||: :|..|.:.|.:.   ...|:.|..::.|:.......|.:.
 Worm   424 RLANIMTDLQH----DVYFYQFDYHNSAGFGVFRWLL---PFLGSTHCTEMRYVLGKGIISKFRP 481

  Fly   491 RTAEFKTIKRLVSMVVHFAISGDPNIPMVCQDEKEQPRGAWLPISKDDKV--FQCLNIS-HDVHV 552
            ...:.|.:..:.:...:||..|:||       .:.|..|.|   .|.|..  |:...|. .|..:
 Worm   482 NDNDKKMLHVMTTYFTNFAKYGNPN-------GENQETGEW---QKHDSAHPFRHFKIDLDDSEM 536

  Fly   553 IDLPEAEKLRLWD 565
            ::..:..:..|||
 Worm   537 VEDYQERRAELWD 549

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est8	NP_524259.2	COesterase	29..564	CDD:278561	153/595 (26%)
		Aes	<116..>221	CDD:223730	50/115 (43%)
cest-27	NP_871861.2	COesterase	29..541	CDD:278561	153/586 (26%)
		Aes	<114..>283	CDD:223730	69/194 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157300
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm14771
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.840