DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est8 and Ces2c

DIOPT Version :9

Sequence 1:	NP_524259.2	Gene:	alpha-Est8 / 40899	FlyBaseID:	FBgn0015576	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_598270.2	Gene:	Ces2c / 171118	RGDID:	621510	Length:	561	Species:	Rattus norvegicus

Alignment Length:	570	Identity:	162/570 - (28%)
Similarity:	250/570 - (43%)	Gaps:	103/570 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 IADTVYGKVKGVKWQSIYGN--NYYSFEGIPFAKPPVGELRFKAPVEPEHWSDVKRCTHVRAKPC 96
            |..|..|:|:| |...:...  ..::|.||||||.|||.|||..|.:||.||.|:..|...|. |
  Rat    35 IRTTHTGQVRG-KLDHVRDTKAGVHTFLGIPFAKAPVGPLRFAPPEDPEPWSGVRDGTSHPAM-C 97

  Fly    97 QVNI-------------VLKQVQGSEDCLYLNVYTRELHPHR--PLPVLVWIYGGGFQMGEASR- 145
            ..||             :|..:..||||||||:|| ..|.|.  .|||:|.|:||...:|.||.
  Rat    98 LQNIDMLDEVGLTDMKMILSSIPMSEDCLYLNIYT-PAHAHEGSNLPVMVCIHGGALVIGMASMC 161

  Fly   146 --DLYSPDYIMMEHVVLVVISYRLGALGFLSLADEELDVPGNAGLKDQVMALRWVKRNCQFFGGD 208
              .|.:    :.|.:|:|.|.||||.|||.|..||.  ..||.|..|||.|||||::|...|||:
  Rat   162 DGSLLA----VNEDLVVVAIQYRLGVLGFFSTGDEH--ARGNWGYLDQVAALRWVQQNIAHFGGN 220

  Fly   209 PDNITVFGESAGGASTHYMMLTDQAKGLFHKTIIMSGSALAPWAQTPTHINWPYRLAQATGYTGD 273
            |:.:|:||.||||.|....:::..::||||..|:.||.||.|...:.|.......:|:.:|.  :
  Rat   221 PNRVTIFGVSAGGTSVSSHVISPMSQGLFHGAIMESGVALLPDLISETSETVSTTVAKLSGC--E 283

  Fly   274 ANDRDIFAHLKKCKASSMLKVAEDIITMEERHQRLTMFSFGPTIEPYLTPHCVIPKSPLEMMRDC 338
            |.|.:......:.|:.:.:.|...:..|                .|.:.....:|:.|.|::...
  Rat   284 ATDSETLVRCLRAKSGAEILVINKVFKM----------------IPAVVDGEFLPRHPKELLASE 332

  Fly   339 WGNSIPMVIGGNSFEGLLMFPEVNKWPELLCQLGDCENLAP--QDAHVDEQQRKAFGKKVRELYF 401
            ..:.:|.:||.|:.|.....|.|....:::.:|.. |||..  :|...........|..:.|.|.
  Rat   333 DFHPVPSIIGVNTDEYCCTIPMVMGTAQIIKELSR-ENLQAVLKDTAAQMMLPPECGDLLMEEYM 396

  Fly   402 GDRTPGRKTILEYSDLF-SYKYFWHGIHRTLLSRAHHAPLAPTFLYRFDFDSKHFNIMRIITCGR 465
            |:....:...::|:::. .:.:....:......|:|    ||.:.|.|.....:|..:|    ..
  Rat   397 GNTDDPQTLQIQYAEMMGDFLFVIPALQVAHFQRSH----APVYFYEFQHAPSYFKNVR----PP 453

  Fly   466 KVRGTCHADDLSYLF----------YNAAAKKLKRRTAEFKTIKRLVSMVVHFAISGDPNI---- 516
            .|:.. |||::.::|          :....|.|.|         |::....:||..|:||.
  Rat   454 HVKAD-HADEVPFVFGSFFWGIKVDFTEEEKLLSR---------RMMKYWANFARHGNPNSEGLP 508

  Fly   517 --PMVCQDEKEQPRGAWLPISKDDKVFQCLNISHDVHVIDLPEAEKLRLW 564
              |::..||:      :|.:.....|.:.|            :|.:|:.|
  Rat   509 YWPVLDHDEQ------YLQLDTQPAVDRAL------------KARRLQFW 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est8	NP_524259.2	COesterase	29..564	CDD:278561	161/568 (28%)
alpha-Est8	NP_524259.2	Aes	<116..>221	CDD:223730	50/109 (46%)
Ces2c	NP_598270.2	COesterase	32..540	CDD:395084	161/568 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.810