DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est8 and Ces3b

DIOPT Version :9

Sequence 1:	NP_524259.2	Gene:	alpha-Est8 / 40899	FlyBaseID:	FBgn0015576	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_653094.2	Gene:	Ces3b / 13909	MGIID:	3644960	Length:	571	Species:	Mus musculus

Alignment Length:	534	Identity:	149/534 - (27%)
Similarity:	228/534 - (42%)	Gaps:	106/534 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 KVI---ADTVYGKVK----GVKWQSIYGNNYYSFEGIPFAKPPVGELRFKAPVEPEHWSDVKRCT 89
            |||   .||..|:|:    |||......|   .|.|||||:.|||.|||.||:.|:.|..| |..
Mouse    33 KVIQPEVDTPLGRVRGRQVGVKDTDRMVN---VFLGIPFAQAPVGPLRFSAPLPPQPWEGV-RDA 93

  Fly    90 HVRAKPC------------QVNIVLKQVQGSEDCLYLNVYT-RELHPHRPLPVLVWIYGGGFQMG 141
            .:....|            .:|..:|....|||||.||:|: .|:......||:|||:||...:|
Mouse    94 SINPPMCLQDVEKMINSRFGLNEKIKIFPISEDCLTLNIYSPTEITAGDKRPVMVWIHGGSLLVG 158

  Fly   142 EASRDLYSPDYIMME---HVVLVVISYRLGALGFLSLADEELDVPGNAGLKDQVMALRWVKRNCQ 203
            .::    |.|...:.   .||:|.:.||||..||||..|:.:  |||.|..|.|.|||||:.|..
Mouse   159 SST----SQDGSALAAYGDVVVVTVQYRLGIFGFLSTGDKHM--PGNRGFLDVVAALRWVQGNIA 217

  Fly   204 FFGGDPDNITVFGESAGGASTHYMMLTDQAKGLFHKTIIMSG-------SALAPWAQTPTHINWP 261
            .|||||:.:|:||.||||.....:.|:..:.||||:.|..||       ..:.||.:.....|
Mouse   218 PFGGDPNCVTIFGNSAGGMIVSSLFLSPISAGLFHRAISQSGIVTTIMMEDMKPWPEAQNFAN-- 280

  Fly   262 YRLAQATGYTGDANDRDIFAHLKKCKASSMLKVAEDIITMEERHQRLTMFSFGPTIEPYLTPHCV 326
                  :...|.|:.    |.|.:|   .:.|..:|:|  ::::..::          |:.....
Mouse   281 ------SVACGSASP----AELVQC---LLQKEGKDLI--KQKNVNIS----------YIVNDSF 320

  Fly   327 IPKSPLEMMRDCWGNSIPMVIGGNSFE-GLLMFPEVNKWPELLCQLGDCENLAPQDAHVDEQQRK 390
            .|:.|.:::.|....::|.::|..:.| |.|:...:|...:|       |:|:.:|.....:...
Mouse   321 FPQRPEKLLADQQFPTVPYLLGVTNHEFGWLLLKSLNILDKL-------EHLSREDLLEISRPFL 378

  Fly   391 AFGKKVREL-------YFGDRTPGRKTILEYSDLFSYKYFWHGIHRTL-LSRAHHAPLAPTFLYR 447
            |..:...|:       |..:.:....|...:.:|.....|   |..|| .|:.......|.|||.
Mouse   379 AIMEVPPEIMPTVIDEYLDNGSDQSATRYAFQELLGDISF---IIPTLNFSKYLRDAGCPVFLYE 440

  Fly   448 FDFDSKHFNIMRIITCGRKVRGTC----HADDLSYLF------YNAAAKKLKRRTAEFKTIK-RL 501
            |......|         .|.:...    ||.:.|::|      ..::.......|.|.|.:. .:
Mouse   441 FQHTPSSF---------AKFKPAWVKADHASENSFVFGGPFLTDESSLLAFPEATEEEKQLSLTM 496

  Fly   502 VSMVVHFAISGDPN 515
            ::....||.:|:||
Mouse   497 MAQWSQFARTGNPN 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est8	NP_524259.2	COesterase	29..564	CDD:278561	149/534 (28%)
alpha-Est8	NP_524259.2	Aes	<116..>221	CDD:223730	46/108 (43%)
Ces3b	NP_653094.2	COesterase	36..547	CDD:278561	146/531 (27%)
		Aes	75..>245	CDD:223730	68/176 (39%)
		Prevents secretion from ER. /evidence=ECO:0000255	568..571
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832485
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.740