Protein Alignment alpha-Est8 and Ces1e

DIOPT Version :9

• Sequence 1: NP_524259.2
• Gene: alpha-Est8 / 40899
• FlyBaseID: FBgn0015576
• Length: 574
• Species: Drosophila melanogaster
• Sequence 2: NP_598421.1
• Gene: Ces1e / 13897
• MGIID: 95432
• Length: 562
• Species: Mus musculus
• Alignment Length: 607
• Identity: 181/607 - (29%)
• Similarity: 269/607 - (44%)
• Gaps: 149/607 - (24%)

  Fly    34 IADTVYGKVKGVKWQSIYG--NNYYSFEGIPFAKPPVGELRFKAPVEPEHWSDVKRCTHVRAKPC 96
            :.|||.|||.| |:.|:.|  .....|.|:||||||:|.|||..|...|.||.||..|.......
Mouse    26 MVDTVQGKVLG-KYISLEGFTQPVAVFLGVPFAKPPLGSLRFAPPQPAEPWSSVKNATSYPPMCF 89

  Fly    97 Q-------VNIVLKQ------VQGSEDCLYLNVYT-RELHPHRPLPVLVWIYGGGFQMGEASRDL 147
            |       ||.:|..      :|.||||||||:|| .:|.....|||:|||:|||..:|.||
Mouse    90 QDPVTGQIVNDLLTNRKEKIPLQFSEDCLYLNIYTPADLTKSDRLPVMVWIHGGGLVLGGAS--- 151

  Fly   148 YSPDYIMM---EHVVLVVISYRLGALGFLSLADEELDVPGNAGLKDQVMALRWVKRNCQFFGGDP 209
             :.|.:::   |:||:|||.||||..||.|..||.  ..||.|..|||.||.||:.|...|||||
Mouse   152 -TYDGLVLSTHENVVVVVIQYRLGIWGFFSTGDEH--SRGNWGHLDQVAALHWVQDNIAKFGGDP 213

  Fly   210 DNITVFGESAGGASTHYMMLTDQAKGLFHKTIIMSGSALA---------PWAQTPTHINWPYRLA 265
            .::|:|||||||.|...::|:..||.||.:.|..||.||.         |.|:         ::|
Mouse   214 GSVTIFGESAGGESVSVLVLSPLAKNLFQRAISESGVALTAGLVKKNTRPLAE---------KIA 269

  Fly   266 QATGYTGDANDRDIFAHLKKCKASSML-----KVAEDII--TMEERHQRLTMFS----------- 312
            ..:|             .|...:::|:     |..|:::  |:     :|.:|.
Mouse   270 VISG-------------CKNTTSAAMVHCLRQKTEEELLGTTL-----KLNLFKLDLHGDSRQSH 316

  Fly   313 -FGPTIEPYLTPHCVIPKSPLEMMRDCWGNSIPMVIGGNSFEGLLMFPEVNKWPELLCQLGDCEN 376
             |.||:    ....::||.|.|::.:...|::|.::|.|..|...:.|.:..:|
Mouse   317 PFVPTV----LDGVLLPKMPEEILAEKNFNTVPYIVGINKQEFGWILPTMMNYP----------- 366

  Fly   377 LAPQDAHVDEQQRKAFGKK--------------VRELYFGDRTPGRKTILEYSDLFSYKYFWHGI 427
              |.|..:|:....:..||              ..|.|..|:....:...:..:|.....|  |:
Mouse   367 --PSDVKLDQMTAMSLLKKSSFLLNLPEDAIAVAIEKYLRDKDYTGRNKDQLLELIGDVVF--GV 427

  Fly   428 HRTLLSRAHHAPLAPTFLYRFDFDSKHFNIMRIITCGRKVRGTCHADDLSYLFYNAAAKKLKRRT 492
            ...::||.|....|||::|.|.:.....:.|:..|    |.|. |.|::..:|   .|..|:..|
Mouse   428 PSVIVSRGHRDAGAPTYMYEFQYSPSFSSEMKPDT----VVGD-HGDEIYSVF---GAPILRGGT 484

  Fly   493 A--EFKTIKRLVSMVVHFAISGDPN---IPMVCQ-DEKEQPRGAWLPISKDDKVFQCLNISHDVH 551
            :  |....|.::....:||.:|:||   :|...: |:||    .:|.|....:
Mouse   485 SEEEINLSKMMMKFWANFARNGNPNGQGLPHWPEYDQKE----GYLQIGATTQ------------ 533

  Fly   552 VIDLPEAEKLRLWDCIYDRELL 573
                 :|:||:..:..:..|||
Mouse   534 -----QAQKLKEKEVAFWTELL 550

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est8	NP_524259.2	COesterase	29..564	CDD:278561	178/596 (30%)
		Aes	<116..>221	CDD:223730	53/108 (49%)
Ces1e	NP_598421.1	COesterase	25..546	CDD:278561	178/601 (30%)
		Aes	44..>242	CDD:223730	92/203 (45%)
		Prevents secretion from ER. /evidence=ECO:0000255	559..562

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832934
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6088
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.690