DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est8 and Ces1c

DIOPT Version :9

Sequence 1:	NP_524259.2	Gene:	alpha-Est8 / 40899	FlyBaseID:	FBgn0015576	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_031980.2	Gene:	Ces1c / 13884	MGIID:	95420	Length:	554	Species:	Mus musculus

Alignment Length:	583	Identity:	173/583 - (29%)
Similarity:	263/583 - (45%)	Gaps:	125/583 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 IADTVYGKVKGVKWQSIYGNNYYSFE-------GIPFAKPPVGELRFKAPVEPEHWSDVKRCT-- 89
            :.||..|||.| |:.|:.|     ||       |:||||||:|.|||..|...|.||.||..|
Mouse    25 VVDTTQGKVLG-KYISLEG-----FEQPVAVFLGVPFAKPPLGSLRFAPPQPAEPWSFVKNATSY 83

  Fly    90 -----------HVRAKPCQVNIVLKQVQGSEDCLYLNVYT-RELHPHRPLPVLVWIYGGGFQMGE 142
                       .:.:........:..::.||||||||:|: .:|.....|||:|||:|||..:|.
Mouse    84 PPMCSQDAGWAKILSDMFSTEKEILPLKISEDCLYLNIYSPADLTKSSQLPVMVWIHGGGLVIGG 148

  Fly   143 ASRDLYSPDYIMM-EHVVLVVISYRLGALGFLSLADEELDVPGNAGLKDQVMALRWVKRNCQFFG 206
            ||.  |:...:.. |:||:|.|.||||..|..|..||.  .|||....||:.|||||:.|...||
Mouse   149 ASP--YNGLALSAHENVVVVTIQYRLGIWGLFSTGDEH--SPGNWAHLDQLAALRWVQDNIANFG 209

  Fly   207 GDPDNITVFGESAGGASTHYMMLTDQAKGLFHKTIIMSGSALAPWAQTPTHINWPYRLAQATGYT 271
            |:||::|:||||:||.|...::|:...|.|||:.|..||..:        :.|...:..||.
Mouse   210 GNPDSVTIFGESSGGISVSVLVLSPLGKDLFHRAISESGVVI--------NTNVGKKNIQAV--- 263

  Fly   272 GDANDRDIFAHLKKCKASSMLKVAEDIITMEERH-----QRLTMFSFGPTIEPYLTPHCVIPKSP 331
                 .:|.|.|.:|..:|...:.:.:....|..     .:|..::...:.   :....|:||:|
Mouse   264 -----NEIIATLSQCNDTSSAAMVQCLRQKTESELLEISGKLVQYNISLST---MIDGVVLPKAP 320

  Fly   332 LEMMRDCWGNSIPMVIGGNSFE-GLLMFPEVNKWPELLCQLGDCENLAPQ--------------- 380
            .|::.:...|::|.::|.|..| |.::       |.:|      :||.|:
Mouse   321 EEILAEKSFNTVPYIVGFNKQEFGWII-------PMML------QNLLPEGKMNEETASLLLRRF 372

  Fly   381 --DAHVDEQQRKAFGKKVRELYF-GDRTPGRKTILEYSDLFSYKYFWHGIHRTLLSRAHHAPLAP 442
              :.::.|....|    |.|.|. |...|.:|:.| ..|:|...:|  ||...||||:.......
Mouse   373 HSELNISESMIPA----VIEQYLRGVDDPAKKSEL-ILDMFGDIFF--GIPAVLLSRSLRDAGVS 430

  Fly   443 TFLYRFDFDSKHFNIMRIITCGRKVRGTCHADDLSYLFYNAAAKKLKRRTAEFKT--IKRLVSMV 505
            |::|.|.:.....:..|..|    |.|. |.|::.::|   .|..||...:|.:|  .|.::...
Mouse   431 TYMYEFRYRPSFVSDKRPQT----VEGD-HGDEIFFVF---GAPLLKEGASEEETNLSKMVMKFW 487

  Fly   506 VHFAISGDPN---IPMVCQ-DEKEQPRGAWLPISKDDKVFQCLNISHDVHVIDLPEAEKLRLW 564
            .:||.:|:||   :|...: ||:|    .:|.|....:..|.|            :||::..|
Mouse   488 ANFARNGNPNGEGLPHWPEYDEQE----GYLQIGATTQQAQRL------------KAEEVAFW 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est8	NP_524259.2	COesterase	29..564	CDD:278561	172/581 (30%)
alpha-Est8	NP_524259.2	Aes	<116..>221	CDD:223730	49/106 (46%)
Ces1c	NP_031980.2	Esterase_lipase	25..525	CDD:238191	168/560 (30%)
		Aes	<121..>234	CDD:223730	53/116 (46%)
		Prevents secretion from ER. /evidence=ECO:0000255	551..554
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832565
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.740