DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est8 and Ces1g

DIOPT Version :9

Sequence 1:	NP_524259.2	Gene:	alpha-Est8 / 40899	FlyBaseID:	FBgn0015576	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_067431.2	Gene:	Ces1g / 12623	MGIID:	88378	Length:	565	Species:	Mus musculus

Alignment Length:	541	Identity:	160/541 - (29%)
Similarity:	245/541 - (45%)	Gaps:	116/541 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 IADTVYGKVKGVKWQSIYGNNYYS-----FEGIPFAKPPVGELRFKAPVEPEHWSDVKRCTHVRA 93
            :..||:|||.| |:.::.|   :|     |.|:||||||:|.|||..|...|.||.||   |..:
Mouse    25 VVHTVHGKVLG-KYVTLEG---FSQPVAVFLGVPFAKPPLGSLRFAPPEPAEPWSFVK---HTTS 82

  Fly    94 KP--CQVN----IVLKQV----------QGSEDCLYLNVYT-RELHPHRPLPVLVWIYGGGFQMG 141
            .|  |..|    :.|.::          :.||||||||:|| .:|..:..|||:|||:|||..:.
Mouse    83 YPPLCYQNPEAALRLAELFTNQRKIIPHKFSEDCLYLNIYTPADLTQNSRLPVMVWIHGGGLVID 147

  Fly   142 EASRDLYSPDYIMM---EHVVLVVISYRLGALGFLSLADEELDVPGNAGLKDQVMALRWVKRNCQ 203
            .||    :.|.:.:   |:||:|||.||||..||.|..||.  ..||.|..|||.||.||:.|..
Mouse   148 GAS----TYDGVPLAVHENVVVVVIQYRLGIWGFFSTEDEH--SRGNWGHLDQVAALHWVQDNIA 206

  Fly   204 FFGGDPDNITVFGESAGGASTHYMMLTDQAKGLFHKTIIMS---------GSALAPWAQTPTHIN 259
            .|||:|.::|:|||||||.|...::|:..||.|||:.|..|         |.|..|.|:
Mouse   207 NFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLFHRAIAQSSVIFNPCLFGRAARPLAK------ 265

  Fly   260 WPYRLAQATGYTGDANDRDIFAHLKKCKASSML--------KVAEDIITMEERHQRLTMFSFGPT 316
               ::|...|                ||.::..        |..::::.:..:.:..|:...|..
Mouse   266 ---KIAALAG----------------CKTTTSAAMVHCLRQKTEDELLEVSLKMKFGTVDFLGDP 311

  Fly   317 IEPY-----LTPHCVIPKSPLEMMRDCWGNSIPMVIGGNSFEGLLMFPEVNKWP----------- 365
            .|.|     :....::||:|.|::.:...|::|.::|.|..|...:.|....:|
Mouse   312 RESYPFLPTVIDGVLLPKAPEEILAEKSFNTVPYMVGINKHEFGWIIPMFLDFPLSERKLDQKTA 376

  Fly   366 -ELLCQLGDCENLAPQDAHVDEQQRKAFGKKVRELYFGDRTPGRKTILEYSDLFSYKYFWHGIHR 429
             .:|.|.....|::          .|.....:.:...|...|...|.| :.||.....|  |:..
Mouse   377 ASILWQAYPILNIS----------EKLIPAAIEKYLGGTEDPATMTDL-FLDLIGDIMF--GVPS 428

  Fly   430 TLLSRAHHAPLAPTFLYRFDFDSKHFNIMRIITCGRKVRGTCHADDLSYLFYNAAAKKLKRRTAE 494
            .::||:|....|||::|.:.:.....:..|    .:::.|. |||:| :..:.|...|......|
Mouse   429 VIVSRSHRDAGAPTYMYEYQYRPSFVSDDR----PQELLGD-HADEL-FSVWGAPFLKEGASEEE 487

  Fly   495 FKTIKRLVSMVVHFAISGDPN 515
            ....|.::....:||.:|:||
Mouse   488 INLSKMVMKFWANFARNGNPN 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est8	NP_524259.2	COesterase	29..564	CDD:278561	160/541 (30%)
alpha-Est8	NP_524259.2	Aes	<116..>221	CDD:223730	51/108 (47%)
Ces1g	NP_067431.2	COesterase	24..545	CDD:278561	160/541 (30%)
Ces1g	NP_067431.2	Aes	<121..>239	CDD:223730	57/123 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832616
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.740