DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est8 and Bche

DIOPT Version :9

Sequence 1:	NP_524259.2	Gene:	alpha-Est8 / 40899	FlyBaseID:	FBgn0015576	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	XP_011238302.1	Gene:	Bche / 12038	MGIID:	894278	Length:	615	Species:	Mus musculus

Alignment Length:	548	Identity:	164/548 - (29%)
Similarity:	253/548 - (46%)	Gaps:	127/548 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 SNDKVIADTVYGKVKGVKWQSIYGNNYYSFEGIPFAKPPVGELRFKAPVEPEHWSDVKRCTHVRA 93
            :.:..|..|..|:|:|:. ..:.|....:|.|||:|:||:|.||||.|.....|.|:...|.. |
Mouse    41 TEEDFIITTKTGRVRGLS-MPVLGGTVTAFLGIPYAQPPLGSLRFKKPQPLNKWPDIHNATQY-A 103

  Fly    94 KPCQVNI--VLKQVQG----------SEDCLYLNVYTRELHPHRPLP------VLVWIYGGGFQM 140
            ..|..||  .....||          |||||||||:.       |:|      |:|||||||||.
Mouse   104 NSCYQNIDQAFPGFQGSEMWNPNTNLSEDCLYLNVWI-------PVPKPKNATVMVWIYGGGFQT 161

  Fly   141 GEASRDLYSPDYI-MMEHVVLVVISYRLGALGFLSLADEELDVPGNAGLKDQVMALRWVKRNCQF 204
            |.:|..:|...:: .:|.|::|.::||:||||||:..... |.|||.||.||.:||:||:||...
Mouse   162 GTSSLPVYDGKFLARVERVIVVSMNYRVGALGFLAFPGNP-DAPGNMGLFDQQLALQWVQRNIAA 225

  Fly   205 FGGDPDNITVFGESAGGASTHYMMLTDQAKGLFHKTIIMSGSALAPWA-QTPTHI-NWPYRLAQA 267
            |||:|.:||:||||||.||....:|..|:..||.:.|:.|||:.|||| :.|... |....||:.
Mouse   226 FGGNPKSITIFGESAGAASVSLHLLCPQSYPLFTRAILESGSSNAPWAVKHPEEARNRTLTLAKF 290

  Fly   268 TGYTGDANDRDIFAHLKKCKASSMLKVAEDIITMEERHQRLTM-------FSFGPTIE-PYLT-- 322
            ||.:.: |:.::.    ||..|   |..::|:    |::|..:       .:||||:: .:||
Mouse   291 TGCSKE-NEMEMI----KCLRS---KDPQEIL----RNERFVLPSDSILSINFGPTVDGDFLTDM 343

  Fly   323 PHCVIPKSPLEMMRDCWGNSIPMVIGGNSFEG--LLMF--PEVNKWPELLCQLGDCENLAPQDAH 383
            ||.::....::..:        :::|.|..||  .|::  |..:|         |.::|.
Mouse   344 PHTLLQLGKVKKAQ--------ILVGVNKDEGTAFLVYGAPGFSK---------DNDSLI----- 386

  Fly   384 VDEQQRKAFGKKVRELYFGDRTPGRKTILEYSDLFSYKYFWHG-----IHRTLLSR--AHHAPLA 441
                .||.|.:.: .:||    ||...:.:.:.|| |...|.|     ::|..|..  ..:..:.
Mouse   387 ----TRKEFQEGL-NMYF----PGVSRLGKEAVLF-YYVDWLGEQSPEVYRDALDDVIGDYNIIC 441

  Fly   442 P--------------TFLYRFDFDSKHFNIMRIITCGRKV-----RGTCHADDLSYLFYNAAAKK 487
            |              .|.|.|:..|.            |:     .|..|..::.::|.....::
Mouse   442 PALEFTKKFAELENNAFFYFFEHRSS------------KLPWPEWMGVMHGYEIEFVFGLPLGRR 494

  Fly   488 LKRRTAEFKTIKRLVSMVVHFAISGDPN 515
            :....||....:.::....:||..|.||
Mouse   495 VNYTRAEEIFSRSIMKTWANFAKYGHPN 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est8	NP_524259.2	COesterase	29..564	CDD:278561	164/548 (30%)
alpha-Est8	NP_524259.2	Aes	<116..>221	CDD:223730	52/111 (47%)
Bche	XP_011238302.1	COesterase	46..563	CDD:365897	164/543 (30%)
Bche	XP_011238302.1	AChE_tetra	578..612	CDD:370053
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910