DRSC/TRiP Functional Genomics Resources

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Protein Alignment alpha-Est8 and Nlgn2

DIOPT Version :9

Sequence 1:NP_524259.2 Gene:alpha-Est8 / 40899 FlyBaseID:FBgn0015576 Length:574 Species:Drosophila melanogaster
Sequence 2:NP_446444.1 Gene:Nlgn2 / 117096 RGDID:621118 Length:836 Species:Rattus norvegicus


Alignment Length:610 Identity:164/610 - (26%)
Similarity:258/610 - (42%) Gaps:130/610 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    34 IADTVYGKVKGVKWQSIYGNN-----YYSFEGIPFAKPPVGELRFKAPVEPEHWSDVKRCTHVRA 93
            :.:|.||:|:||:.:.   ||     ...|.|:|:|.||:|..||:.|..|..|..|:..|.: .
  Rat    43 VVNTAYGRVRGVRREL---NNEILGPVVQFLGVPYATPPLGARRFQPPEAPASWPGVRNATTL-P 103

  Fly    94 KPCQVNI-------------------VLKQVQG-SEDCLYLNVYT-------------------- 118
            ..|..|:                   ....||. ||||||||:|.                    
  Rat   104 PACPQNLHGALPAIMLPVWFTDNLEAAATYVQNQSEDCLYLNLYVPTEDGPLTKKRDEATLNPPD 168

  Fly   119 RELHPHRPLPVLVWIYGGGFQMGEASRDLYSPDYI-MMEHVVLVVISYRLGALGFLSLADEELDV 182
            .::......||:::::||.:.  |.:.:::....: ...:|::..::||||.|||||..|:.  .
  Rat   169 TDIRDSGKKPVMLFLHGGSYM--EGTGNMFDGSVLAAYGNVIVATLNYRLGVLGFLSTGDQA--A 229

  Fly   183 PGNAGLKDQVMALRWVKRNCQFFGGDPDNITVFGESAGGASTHYMMLTDQAKGLFHKTIIMSGSA 247
            .||.||.||:.||||:..|...|||||:.||:||..||.:..:.::|:..::|||.|.|..||:|
  Rat   230 KGNYGLLDQIQALRWLSENIAHFGGDPERITIFGSGAGASCVNLLILSHHSEGLFQKAIAQSGTA 294

  Fly   248 LAPWAQTPTHINWPYRLAQATGYTGDANDRDIFAHLKKC--KASSMLKVAEDIITMEERHQRLTM 310
            ::.|:.....:.:...||...|.     ||:......:|  :.||...|.:|:  ...|:.    
  Rat   295 ISSWSVNYQPLKYTRLLAAKVGC-----DREDSTEAVECLRRKSSRELVDQDV--QPARYH---- 348

  Fly   311 FSFGPTIEPYLTPHCVIPKSPLEMMRDCWGNSIPMVIGGNSFEGLLMFPEVNKWPELLCQLGDCE 375
            .:|||.::     ..|:|..|..:|:.....:..|:||.|..|||       |:.|...:..|..
  Rat   349 IAFGPVVD-----GDVVPDDPEILMQQGEFLNYDMLIGVNQGEGL-------KFVEDSAESEDGV 401

  Fly   376 NLAPQDAHVDEQQRKAFG---------KKVRELY--FGDRTPG---RKTILEYSDLFSYKYFWHG 426
            :.:..|..|.......:|         :.::.:|  :.||..|   |||:|.   ||: .:.|  
  Rat   402 SASAFDFTVSNFVDNLYGYPEGKDVLRETIKFMYTDWADRDNGEMRRKTLLA---LFT-DHQW-- 460

  Fly   427 IHRTLLSRAHHAPL-APTFLYRFDFDSKHFNIMRIITCGRKVR----GTCHADDLSYLFYNAAAK 486
            :...:.:...||.. :|.:.|.|    .|.       |..:.|    ...|.|:|.|:|......
  Rat   461 VAPAVATAKLHADYQSPVYFYTF----YHH-------CQAEGRPEWADAAHGDELPYVFGVPMVG 514

  Fly   487 KLKRRTAEFKTIKRLVSMVV-----HFAISGDPNIPMVCQDEK---EQPRG----AWLPISKDDK 539
            ........|.....::|.||     :||.:||||.| |.||.|   .:|..    .|...:..:|
  Rat   515 ATDLFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQP-VPQDTKFIHTKPNRFEEVVWSKFNSKEK 578

  Fly   540 VFQCLNISHDVHVIDLPEAEKLRLW 564
              |.|:|.....|.|...|.|:..|
  Rat   579 --QYLHIGLKPRVRDNYRANKVAFW 601

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
alpha-Est8NP_524259.2 COesterase 29..564 CDD:278561 163/608 (27%)
Aes <116..>221 CDD:223730 38/125 (30%)
Nlgn2NP_446444.1 COesterase 42..601 CDD:395084 163/608 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 623..661
Required for interaction with LHFPL4. /evidence=ECO:0000250|UniProtKB:Q69ZK9 679..699
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 711..735
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 791..836
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166336470
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.840

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