DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est8 and ache

DIOPT Version :9

Sequence 1:	NP_524259.2	Gene:	alpha-Est8 / 40899	FlyBaseID:	FBgn0015576	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_571921.1	Gene:	ache / 114549	ZFINID:	ZDB-GENE-010906-1	Length:	634	Species:	Danio rerio

Alignment Length:	578	Identity:	168/578 - (29%)
Similarity:	255/578 - (44%)	Gaps:	103/578 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 DKVIADTVYGKVKGVKWQSIYGNNYYSFEGIPFAKPPVGELRFKAPVEPEHWSDVKRCTHVRAKP 95
            |.|:| |..|:|:|.:......::..:|.|||:|:||:|:.|||.....:.|::|...... :..
Zfish    28 DLVVA-TRLGRVQGTRLPVPDRSHVIAFLGIPYAEPPIGKRRFKRAEPKKPWNNVFEAKEF-SNA 90

  Fly    96 C-----------------QVNIVLKQVQGSEDCLYLNVYTRELHPHRPLP----VLVWIYGGGFQ 139
            |                 ..|.|:     |||||||||:.    |..|.|    |:||||||||.
Zfish    91 CYQFVDTSYPGFPGIEMWNPNRVM-----SEDCLYLNVWV----PPTPRPQNLTVMVWIYGGGFY 146

  Fly   140 MGEASRDLYSPDYI-MMEHVVLVVISYRLGALGFLSLADEELDVPGNAGLKDQVMALRWVKRNCQ 203
            .|.:|.|:|...|: ..|.||:|.::||:||.|||:| :...|.|||.||.||.:||:||:.|..
Zfish   147 SGSSSLDVYDGRYLAYTEKVVVVSMNYRVGAFGFLAL-NGSSDAPGNVGLYDQRLALQWVQENIH 210

  Fly   204 FFGGDPDNITVFGESAGGASTHYMMLTDQAKGLFHKTIIMSGSALAPWAQTPTHINWPYR---LA 265
            ||||:|..:|:||||||.||....:|:..::.||.:.|:.||....||| |.|......|   |.
Zfish   211 FFGGNPKQVTIFGESAGAASVGMHVLSPDSRPLFTRAILQSGVPNTPWA-TVTFDEARRRTTKLG 274

  Fly   266 QATGYTGDANDRDIFAHLKKCKASSMLKVAEDIITMEER---HQRLTMFSFGPTIEPYLTPHCVI 327
            :..|.|. .||.::...|:.       |..:::|..|.:   ...|..|||.|.::...     .
Zfish   275 KLVGCTW-GNDTELIDCLRN-------KHPQELIDQEWQVLPWSSLFRFSFVPVVDGVF-----F 326

  Fly   328 PKSPLEMMRDCWGN--SIPMVIGGNSFEG--LLMF--PEVNKWPELLCQLGD-CENLAPQDAHVD 385
            |.:|..|:..  ||  ...:::|.|..||  .|::  |..:|..|.|....| .|::.....|.:
Zfish   327 PDTPDAMISS--GNFKYTQILLGVNQDEGSYFLLYGAPGFSKDNESLISREDFLESVKMGVPHAN 389

  Fly   386 EQQRKAF------------GKKVRELYFGDRTPGRKTILEYSDLFSYKYFWHGIHRTLLSRAHHA 438
            :...:|.            |:|.|:..  |...|.:.::.....|:..|..:.......|.|...
Zfish   390 DIGLEAVILQYTDWMDENNGQKNRDAM--DDIVGDQNVICPLQHFAKSYAQYAALHAQSSAAAPG 452

  Fly   439 PL-----APT-----------FLYRFDFDSKHFNIMRIITCGRKVRGTCHADDLSYLFYNAAAKK 487
            .|     .||           :||.||..:.:.       ...:..|..|..::.::|.....|:
Zfish   453 TLGWGNSGPTGYNSGNSHGAVYLYLFDHRASNL-------AWPEWMGVIHGYEIEFVFGLPLEKR 510

  Fly   488 LKRRTAEFKTIKRLVSMVVHFAISGDPNIPMVCQDEKEQPRGAWLPISKDDKVFQCLN 545
            |.....|.|..:|::....:||.:|:||   |..|.....|..|...|.:::....||
Zfish   511 LNYTAEEEKLSRRIMRYWANFARTGNPN---VNTDGTMDSRRRWPQFSANEQKHVGLN 565

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est8	NP_524259.2	COesterase	29..564	CDD:278561	168/578 (29%)
alpha-Est8	NP_524259.2	Aes	<116..>221	CDD:223730	54/109 (50%)
ache	NP_571921.1	COesterase	23..583	CDD:278561	168/578 (29%)
ache	NP_571921.1	AChE_tetra	598..631	CDD:285837
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575600
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.840