DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est8 and Ces1d

DIOPT Version :9

Sequence 1:	NP_524259.2	Gene:	alpha-Est8 / 40899	FlyBaseID:	FBgn0015576	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_579829.3	Gene:	Ces1d / 113902	RGDID:	70896	Length:	565	Species:	Rattus norvegicus

Alignment Length:	579	Identity:	186/579 - (32%)
Similarity:	264/579 - (45%)	Gaps:	134/579 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 IADTVYGKVKGVKWQSIYG--NNYYSFEGIPFAKPPVGELRFKAPVEPEHWSDVKRCTHVRAKP- 95
            :.:||.|||.| |:.::.|  .....|.||||||||:|.|||..|...|.|:.||..|   :.|
  Rat    25 VVNTVKGKVLG-KYVNLEGFAQPVAVFLGIPFAKPPLGSLRFAPPQPAEPWNFVKNTT---SYPP 85

  Fly    96 -CQVNIVLKQV--------------QGSEDCLYLNVYT-RELHPHRPLPVLVWIYGGGFQMGEAS 144
             |..:.|..||              |.||||||||||| .:|..:..|||:|||:|||..:|.||
  Rat    86 MCSQDAVGGQVLSELFTNRKENIPLQFSEDCLYLNVYTPADLTKNSRLPVMVWIHGGGLVVGGAS 150

  Fly   145 RDLYSPDYIMM-EHVVLVVISYRLGALGFLSLADEELDVPGNAGLKDQVMALRWVKRNCQFFGGD 208
              .|....:.. |:||:|.|.||||..||.|..||...  ||.|..|||.||.||:.|...|||:
  Rat   151 --TYDGQVLSAHENVVVVTIQYRLGIWGFFSTGDEHSQ--GNWGHLDQVAALHWVQDNIANFGGN 211

  Fly   209 PDNITVFGESAGGASTHYMMLTDQAKGLFHKTIIMSG----SALAPWAQTPTHINWPYRLAQATG 269
            |.::|:|||||||.|...::|:..||.|||:.|..||    |||......|.
  Rat   212 PGSVTIFGESAGGFSVSALVLSPLAKNLFHRAISESGVVLTSALITTDSKPI------------- 263

  Fly   270 YTGDANDRDIFAHLKKCKASSML--------KVAEDIITMEERHQRLTMFS------------FG 314
                ||   :.|.|..||.::..        |..::::   |...:|.:|.            |.
  Rat   264 ----AN---LIATLSGCKTTTSAVMVHCLRQKTEDELL---ETSLKLNLFKLDLLGNPKESYPFL 318

  Fly   315 PTIEPYLTPHCVIPKSPLEMMRDCWGNSIPMVIGGNSFEGLLMFPEVNKWPELLCQLGDCENLAP 379
            ||:    ....|:||:|.|::.:...|::|.::|.|..|...:.|.:..:|             .
  Rat   319 PTV----IDGVVLPKTPEEILTEKSFNTVPYIVGINKQEFGWIIPTLMGYP-------------L 366

  Fly   380 QDAHVDEQQRKAFGKK--------------VRELYFG--DRTPGRKTILEYSDLFSYKYFWHGIH 428
            .:..:|::..|:...|              |.|.|||  |....||.:  :.||.:...|  |:.
  Rat   367 SEGKLDQKTAKSLLWKSYPTLKISEKMIPVVAEKYFGGTDDPAKRKDL--FQDLVADVMF--GVP 427

  Fly   429 RTLLSRAHHAPLAPTFLYRFDFDSKHFNIMRIITCGRKVRGTCHADDLSYLFYNAAAKKLKRRTA 493
            ..::||:|....||||:|.|::.....:.||    .:.|.|. |.|:|..:|   .:..||...:
  Rat   428 SVMVSRSHRDAGAPTFMYEFEYRPSFVSAMR----PKTVIGD-HGDELFSVF---GSPFLKDGAS 484

  Fly   494 EFKTIKRLVSMVV----HFAISGDPN---IPMVCQ-DEKEQPRGAWLPISKDDKVFQCL 544
            |.:|  .|..||:    :||.:|.||   :|...: |:||    .:|.|....:..|.|
  Rat   485 EEET--NLSKMVMKYWANFARNGSPNGGGLPHWPEYDQKE----GYLKIGASTQAAQRL 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est8	NP_524259.2	COesterase	29..564	CDD:278561	186/579 (32%)
alpha-Est8	NP_524259.2	Aes	<116..>221	CDD:223730	52/106 (49%)
Ces1d	NP_579829.3	COesterase	24..545	CDD:278561	186/579 (32%)
		Aes	<121..>239	CDD:223730	58/121 (48%)
		Prevents secretion from ER. /evidence=ECO:0000255	562..565
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336154
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.840