Protein Alignment alpha-Est8 and CES1

DIOPT Version :9

• Sequence 1: NP_524259.2
• Gene: alpha-Est8 / 40899
• FlyBaseID: FBgn0015576
• Length: 574
• Species: Drosophila melanogaster
• Sequence 2: NP_001020366.1
• Gene: CES1 / 1066
• HGNCID: 1863
• Length: 568
• Species: Homo sapiens
• Alignment Length: 609
• Identity: 190/609 - (31%)
• Similarity: 266/609 - (43%)
• Gaps: 145/609 - (23%)

  Fly    34 IADTVYGKVKGVKWQSIYG--NNYYSFEGIPFAKPPVGELRFKAPVEPEHWSDVKRCTHVRAKPC 96
            :.|||:|||.| |:.|:.|  .....|.||||||||:|.|||..|...|.||.||..|.......
Human    26 VVDTVHGKVLG-KFVSLEGFAQPVAIFLGIPFAKPPLGPLRFTPPQPAEPWSFVKNATSYPPMCT 89

  Fly    97 Q----------------VNIVLKQVQGSEDCLYLNVYT-RELHPHRPLPVLVWIYGGGFQMGEAS 144
            |                .||.||.   ||||||||:|| .:|.....|||:|||:|||..:|.||
Human    90 QDPKAGQLLSELFTNRKENIPLKL---SEDCLYLNIYTPADLTKKNRLPVMVWIHGGGLMVGAAS 151

  Fly   145 RDLYSPDYIMM---EHVVLVVISYRLGALGFLSLADEELDVPGNAGLKDQVMALRWVKRNCQFFG 206
                :.|.:.:   |:||:|.|.||||..||.|..||.  ..||.|..|||.|||||:.|...||
Human   152 ----TYDGLALAAHENVVVVTIQYRLGIWGFFSTGDEH--SRGNWGHLDQVAALRWVQDNIASFG 210

  Fly   207 GDPDNITVFGESAGGASTHYMMLTDQAKGLFHKTIIMSGSALA----------PWAQ-------- 253
            |:|.::|:|||||||.|...::|:..||.|||:.|..||.||.          |.|:
Human   211 GNPGSVTIFGESAGGESVSVLVLSPLAKNLFHRAISESGVALTSVLVKKGDVKPLAEQIAITAGC 275

  Fly   254 -TPTHINWPYRLAQATGYTGDANDRDIFAHLKKCKASSMLKVAEDIITMEERHQRLTMFSFGPTI 317
             |.|.....:.|.|.|       :.::.....|.|..|:     |:.......|.|    .|..|
Human   276 KTTTSAVMVHCLRQKT-------EEELLETTLKMKFLSL-----DLQGDPRESQPL----LGTVI 324

  Fly   318 EPYLTPHCVIPKSPLEMMRDCWGNSIPMVIGGNSFE-GLLMFPEVNKWP---------------- 365
            :..|     :.|:|.|:..:...:::|.::|.|..| |.|:..::..:|
Human   325 DGML-----LLKTPEELQAERNFHTVPYMVGINKQEFGWLIPMQLMSYPLSEGQLDQKTAMSLLW 384

  Fly   366 ---ELLCQLGDCENLAPQDAHVDEQQRKAFGKKVRELYFG--DRTPGRKTILEYSDLFSYKYFWH 425
               .|:|   ..:.|.|:               ..|.|.|  |.|..:|.:  :.||.:...|
Human   385 KSYPLVC---IAKELIPE---------------ATEKYLGGTDDTVKKKDL--FLDLIADVMF-- 427

  Fly   426 GIHRTLLSRAHHAPLAPTFLYRFDFDSKHFNIMRIITCGRKVRGTCHADDLSYLFYNAAAKKLKR 490
            |:...:::|.|....|||::|.|.:.....:.|:    .:.|.|. |.|:|..:|   .|..||.
Human   428 GVPSVIVARNHRDAGAPTYMYEFQYRPSFSSDMK----PKTVIGD-HGDELFSVF---GAPFLKE 484

  Fly   491 RTAEFKTIKRLVSMVV----HFAISGDPN---IPMVCQDEKEQPRGAWLPIS---------KDDK 539
            ..:|.:.  ||..||:    :||.:|:||   :|.  ..|..|..| :|.|.         ||.:
Human   485 GASEEEI--RLSKMVMKFWANFARNGNPNGEGLPH--WPEYNQKEG-YLQIGANTQAAQKLKDKE 544

  Fly   540 VFQCLNISHDVHVIDLPEAEKLRL 563
            |....|:.....|...|:.|.:.|
Human   545 VAFWTNLFAKKAVEKPPQTEHIEL 568

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est8	NP_524259.2	COesterase	29..564	CDD:278561	190/609 (31%)
		Aes	<116..>221	CDD:223730	52/108 (48%)
CES1	NP_001020366.1	COesterase	25..548	CDD:278561	185/587 (32%)
		Aes	<122..>240	CDD:223730	58/123 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142663
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	216	1.000	Inparanoid score	I3612
Isobase	1	0.950	-	0	Normalized mean entropy	S6088
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.740